Author: "Gorgoshidze Bv" / Topic: adenoma - Searchworks@Jio Institute Digital Library Search Results

Author: Gorgoshidze BV, Sabakhtarashvili MA, Veinberg EG, Kurashvili RB, and Dundua MG
Subjects: Adolescent, Adult, Blood Glucose metabolism, Circadian Rhythm, Female, Humans, Pregnancy, Adenoma blood, Galactorrhea blood, Growth Hormone blood, Lactation Disorders blood, Pituitary Neoplasms blood, Prolactin blood
Published: 1983
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Author: Sabakhtarashvili Ma, Gorgoshidze Bv, Kurashvili Rb, Dundua Mg, and É. G. Veinberg
Subjects: Adenoma, Adult, Blood Glucose, medicine.medical_specialty, Somatotropic cell, Adolescent, Glucose challenge, Lactation Disorders, Biology, Basal (phylogenetics), Pituitary adenoma, Pregnancy, Internal medicine, medicine, Humans, In patient, Pituitary Neoplasms, Circadian rhythm, Pituitary microadenoma, Somatotropin secretion, General Neuroscience, Galactorrhea, medicine.disease, Circadian Rhythm, Prolactin, Endocrinology, Growth Hormone, Female
Abstract: 1. HPL patients characteristically show depressed basal levels of STH. 2. Patients with HPL and radiologically confirmed pituitary adenoma show an altered response of the somatotropic structures to glucose challenge and marked circadian variations in the STH circadian pattern. 3. In patients without a radiological sign of pituitary adenoma STH levels are depressed but the circadian rhythm resembles the normal pattern; the STH fails to show a response to a glucose load and in GTT the STH concentration plot is flattened. 4. The severity of somatotropic functional alteration in HPL is not as important as the nature of the pathologic substrate which underlies the disease. 5. Studies on the circadian STH pattern and its fluctuations in GTT may provide objective criteria in the diagnosis of pituitary microadenoma.
Published: 1983

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