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1. The multidisciplinary management of gastro-oesophageal junction tumours: European Society of Digestive Oncology (ESDO): Expert discussion and report from the 16th ESMO World Congress on Gastrointestinal Cancer, Barcelona.

Author

Van Laethem JL, Carneiro F, Ducreux M, Messman H, Lordick F, Ilson DH, Allum WH, Haustermans K, Lepage C, Matysiak-Budnik T, Cats A, Schmiegel W, Cervantes A, Van Cutsem E, Rougier P, and Seufferlein T

Subjects
Congresses as Topic, Drug Therapy, Endoscopy, Gastrointestinal, Esophagostomy, Evidence-Based Medicine, Gastrectomy, Humans, Medical Oncology, Neoplasm Staging, Nutritional Support, Palliative Care, Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Societies, Medical, Spain, World Health Organization, Adenocarcinoma pathology, Esophageal Neoplasms pathology, Esophageal Neoplasms therapy, Esophagogastric Junction pathology, Stomach Neoplasms pathology, Stomach Neoplasms therapy
Abstract

Background and Scope: The management of GOJ cancers remains controversial and may vary between countries. Evidence-based attitudes and guidelines are not easy to elaborate since most of the trials and studies reported mixed cases of oesophageal (both adenocarcinoma and squamous cell tumours), GOJ and gastric cancers. The aim of this expert discussion and position paper is to elaborate practical recommendations that integrate evidence-reported literature and experience-based attitude covering all clinical aspects of GOJ cancer across different specialities and countries in Europe., Methodology: Opinion leaders, selected on scientific merit were asked to answer to a prepared set of questions covering the approach of GOJ tumours from definition to therapeutic strategies. All answers were then discussed during a plenary session and reported here in providing a well-balanced reflection of both clinical expertise and updated evidence-based medicine., Results: Definition, classification, diagnosis and staging of GOJ tumours were updated and debated. Therapeutic aspects including endoscopic therapy, surgical management, both multimodal curative and palliative management were also reviewed for proposing practical and consensual positions and recommendations whenever possible., Conclusion: GOJ tumours deserve specific attention,not only for uniformising clinical management across countries but also for performing specific clinical and translational research,mainly in the curative perioperative setting., (Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Published
2016
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2. The multidisciplinary management of gastro-oesophageal junction tumours: European Society of Digestive Oncology (ESDO): Expert discussion and report from the 16th ESMO World Congress on Gastrointestinal Cancer, Barcelona

Author

Van Laethem, J.-L., Carneiro, F., Ducreux, M., Messman, H., Lordick, F., Ilson, D.H., Allum, W., Haustermans, K, Lepage, C., Matysiak-Budnik, T., Cats, A, Schmiegel, W, Cervantes, A, Van Cutsem, E, Rougier, Ph, Seufferlein, Th, Service de Gastro-Entérologie, d'Hépato-Pancréatologie et d'Oncologie Digestive - Endoscopie Digestive (hôpital Erasme), Université Libre de Bruxelles [Bruxelles] (ULB)-Hôpital Erasme (Bruxelles), Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) and Medical Fa, Oncologie digestive, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Department of Internal Medicine (Klinikum Augsburg), Klinikum Augsburg, Universität Leipzig [Leipzig], Memorial Sloane Kettering Cancer Center [New York], Royal Marsden Hospital NHS Foundation Trust, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University Hospitals Leuven [Leuven], Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Service d'hépato-gastro-entérologie, cancérologie digestive et assistance nutritionnelle [CHU de Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Medizinische Universitätsklinik, Ruhr-Universität Bochum [Bochum], Abtlg. Gastroenterologie und Hepatologie, INCLIVA, Universitat de València (UV), Université Paris Descartes - Paris 5 (UPD5), Universität Ulm - Ulm University [Ulm, Allemagne], Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Université Libre de Bruxelles [Bruxelles] ( ULB ) -Hôpital Erasme (Bruxelles), Institut Gustave Roussy ( IGR ) -Institut Gustave Roussy ( IGR ), Institut Gustave Roussy ( IGR ), Memorial Sloan Kettering Cancer Center ( MSKCC ), Katholieke Universiteit Leuven ( KU Leuven ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Netherlands Cancer Institute ( NKI ), Universitat de València ( UV ), Université Paris Descartes - Paris 5 ( UPD5 ), Ulm University, Université libre de Bruxelles (ULB)-Hôpital Erasme [Bruxelles] (ULB), and Université libre de Bruxelles (ULB)

Subjects
Esophageal Neoplasms, Esophageal Cancer, Adenocarcinoma, Clinical-Trial, Phase-Iii Trial, Medical Oncology, World Health Organization, Endoscopy, Gastrointestinal, Drug Therapy, Gastrectomy, Stomach Neoplasms, Perioperative Chemotherapy, Humans, Societies, Medical, Neoplasm Staging, Randomized Controlled Trials as Topic, Radiofrequency Ablation, Evidence-Based Medicine, Nutritional Support, Palliative Care, Endoscopic treatment, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Congresses as Topic, Term Survival Differences, Advanced Gastric-Cancer, Spain, Advanced Esophagogastric Cancer, Practice Guidelines as Topic, Gastro-oesophageal junction cancer, [ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Endoscopic Submucosal Dissection, Esophagogastric Junction, Resectable Esophageal, Esophagostomy, Multimodal therapy
Abstract

IF 2.719; International audience; The management of GOJ cancers remains controversial and may vary between countries. Evidence-based attitudes and guidelines are not easy to elaborate since most of the trials and studies reported mixed cases of oesophageal (both adenocarcinoma and squamous cell tumours), GOJ and gastric cancers. The aim of this expert discussion and position paper is to elaborate practical recommendations that integrate evidence-reported literature and experience-based attitude covering all clinical aspects of GOJ cancer across different specialities and countries in Europe.Opinion leaders, selected on scientific merit were asked to answer to a prepared set of questions covering the approach of GOJ tumours from definition to therapeutic strategies. All answers were then discussed during a plenary session and reported here in providing a well-balanced reflection of both clinical expertise and updated evidence-based medicine.Definition, classification, diagnosis and staging of GOJ tumours were updated and debated. Therapeutic aspects including endoscopic therapy, surgical management, both multimodal curative and palliative management were also reviewed for proposing practical and consensual positions and recommendations whenever possible.GOJ tumours deserve specific attention,not only for uniformising clinical management across countries but also for performing specific clinical and translational research,mainly in the curative perioperative setting.

Published
2016
Full Text
View/download PDF

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