1. DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.
- Author
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Kannuna H, Rubio CA, Silverio PC, Girardin M, Goossens N, Rubbia-Brandt L, and Puppa G
- Subjects
- Adenocarcinoma chemistry, Adenocarcinoma classification, Adenocarcinoma surgery, Biomarkers, Tumor analysis, Biopsy, Cecal Neoplasms chemistry, Cecal Neoplasms classification, Cecal Neoplasms surgery, Colectomy, Colonic Neoplasms chemistry, Colonic Neoplasms classification, Colonic Neoplasms surgery, Colonoscopy, Diagnosis, Differential, Female, Humans, Immunohistochemistry, Lymphoid Tissue chemistry, Lymphoid Tissue surgery, Middle Aged, Neoplasm Grading, Neoplasm Staging, Phenotype, Predictive Value of Tests, Terminology as Topic, Time Factors, Treatment Outcome, Adenocarcinoma pathology, Cecal Neoplasms pathology, Colonic Neoplasms pathology, Lymphoid Tissue pathology
- Abstract
Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.
- Published
- 2015
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