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Introduction: Alcohol dysphoria is a pathognomonic, severe, and therapeutically resistant syndrome considerable for alcohol and drug-addicted patients. The term "dysphoria" (from Greek δυσφορέω to suffer, torment, annoy) means an abnormally low type of mood, characterized by anger, gloom, irritability, feelings of hostility to others. In addictology, it is often identified in the withdrawal syndrome structure. Objectives: To develop innovative improvement in treatment for alcohol dysphoria. Methods: Valid clinical diagnostic, laboratory, biochemical, electrophysiological, psychological (scaling, testing), statistical methods identifying alcohol dependence complicated by dysphoria. Results: The proposed method involves a complex of anti-affective, anti-abstinence, anti-craving pharmacological agents and drug-free methods, and differs from those conventional, along with psychotherapeutic potentiation, by additional targeted pharmacological triad (peroral Carbamazepine 200 mg twice a day: in the morning and in the evening; intramuscular Halopril (Haloperidol) 1 ml (5 mg) daily; oral Sonapax 1 tablet (25 mg) three times a day for 3-5 day treatment) used for a new purpose. 17 patients experienced this method. Efficacy: alcohol dysphoria acute manifestations were relieved by our method within 3-5 days that 37.8% exceeds conventional treatment. In 15 minutes, patients decreased irritability, motor restlessness, stress, cravings for alcohol. In 30 minutes, the patients fell asleep. Sleep lasted 3.5 hours on average. Subsequently, patients denied craving for alcohol, calmed down emotionally and psychomotorically, wished to be treated for alcoholism. No dysphoric relapses were observed. Conclusions: The proposed multimodality method alleviates alcohol-induced dysphoria, involving pharmacotherapeutic triad along with psychotherapeutic potentiation. [ABSTRACT FROM AUTHOR]

Introduction: Hepatobiliary disorders in alcohol dependent patients is the prevalent dual morbidity with steady upward trend of 15-30% annual increase. Therefore, development of new, more effective, integrated approaches to dual morbidity (alcohol dependence + alcoholic liver disease) treatment is quite relevant. Objectives: Research for creative task of innovative metamorphosis of integrated therapy for alcohol dependence, complicated by liver comorbidity, using essential synergistic anti-alcohol methods and differentiated choice of modern pharmacological hepatoprotective drugs. Methods: Modern complex of clinical and psychopathological pathopsychological, laboratory, electrophysiological, biochemical examination to identify dual comorbidity. Results:Anewmethod of integrated therapy for alcohol dependence complicated by liver comorbidity (patent 96702, UA) using conventional anti-alcohol and hepatoprotective pharmacotherapy has been proposed. Novelty of the utility model is provided by therapeutically combined anti-alcohol, hepatoprotective and psychotherapeutic agents: a) synchronous administration of intravenous and oral new-generation hepatoprotectors, adjuvantly affecting various pathogenic mechanisms of liver function alcoholic impairment: Lesfal 5.0ml intravenously (7-10 per course), Antral 1 tablet (0.2 g) 3 times a day (14-21 day per course); b) treatment against the background of nanotechnological membrane plasmapheresis ("Hemofenix" unit, 2-3 sessions of 750-850 ml blood plasma exfusion per session; c) psychotherapeutic mediating of the present visual signs caused by chronic alcohol intoxication with metabolic toxic (xenobiotic) contamination at plasma membrane plasmapheresis exfusion. Conclusions: Catamnesis of representative group of patients statistically objectified the increased treatment efficiency of dual comorbidity, primarily due to the quality of remissions, persistent Conclusions: Catamnesis of representative group of patients statistically objectified the increased treatment efficiency of dual comorbidity, primarily due to the quality of remissions, persistent. [ABSTRACT FROM AUTHOR]

Introduction: Contemporary international addictology, as a neuroscience, concentrated a large array of theoretical and applied knowledge about alcohol dependence pathogenetic mechanisms, exogenous and endogenous intoxication leading role, urgent states of alcohol genesis, decompensated detoxification mechanisms. This fact is of key importance in the development, testing and accumulation of numerous treatment modalities for alcohol dependence conditions and urgent relief in addictology practice. Unfortunately, not all proposed therapeutic programs stand the test of time for effectiveness. Objectives: Based on the analytical review of the principles of intensive elimination of post-alcohol disorders, to develop an innovative method of complex detoxification therapy for emergency conditions of alcohol genesis (withdrawal syndrome, dipsomania, pre-delirious and delirious conditions, etc.). Methods: International tests and scales for identification of alcohol dependence and its complications as emergency conditions. Follow-up control of laboratory, biochemical, electrophysiological and other studies. Results: An innovative method of complex detoxification therapy in emergency states of alcohol genesis (patent 20470, UA) by plasmapheresis method is developed, which is specific for membrane plasmapheresis with a dosed blood plasma removal volume of 600.0-1000.0 ml, and directly pre-treatment drip-feed intravenous administration of 200.0-400.0 ml Rheosorbilact or Sorbilact (by new prescription), 2.0-3.0 ml nicotinic acid intramuscularly, and medical oxygen inhalation for 5-10 minutes, every other 3 days procedure, 2-3 procedures tolally per treatment. Conclusions: The proposed detoxification method quickly and effectively reduces emergency clinical manifestations (eg., alcohol withdrawal syndrome with predilirious condition after prolonged binge drinking) and normalizes laboratory, electrophysiological and other parameters (middle weight molecules content, malondialdehyde level). [ABSTRACT FROM AUTHOR]

Introduction: Intensive elimination of intoxication factors is an essential component of therapeutic programs for emergency states common enough among the drug addicts. However, most of the known detoxification methods are insufficiently effective. Objectives: The creative task was to develop considerably and improve intensive detoxification treatment modality in emergency states of narcotic genesis. Methods: International scales and tests for identification of drug dependence and relieving emergency states of narcotic genesis. The study monitored the dynamics of the main biochemical, major clinical laboratory and electrophysiological parameters. Results: Aiming to increase significantly detoxification efficiency, our utility model "Method of intensive detoxification therapy in emergency states of narcotic genesis" (patent 24574, UA) provides membrane plasmapheresis (MPP) at minimized conventional pharmacotherapy with dosed 600.0-1000.0 ml blood exfusion, and hyperbaric oxygen therapy (HBO) 12-14 hours after the procedure, with 1.2-1.3 atm oxygen pressure in the chamber, and 45-60 minutes exposure; every 3 days MPP procedure re-treatment (2-3 courses totally for a course), and a 3-5 session course of daily HBO. It has been proved that MPP pathogenetically provides intensive extracorporeal exfusion of toxic substances from circulating blood plasma. Hyperbaric oxygen promotes generalized detoxification, improves metabolic, detoxification processes, promotes elimination of hypoxic factor, positively influences (stimulates functional activity of the cardiovascular system, including capillary), adding synergistic preconditions for plasmapheretic exfusion of toxins and harmful metabolites excreted in circulation. Conclusions: The phenomenon of synergistically combined two best methods of detoxification (MPP + HBO) statistically significantly increases the treatment effectiveness for emergency conditions of narcotic genesis. [ABSTRACT FROM AUTHOR]

Introduction: The emergency states caused by periodic forms of compulsive craving for alcohol (the so called "dipsomania alcohol abuse", "heavy drinking bouts"), while which patients completely lose their conscious ability for determined will efforts over quantitative and situational self-control use of alcohol toxic megadoses, are considered one of the urgent issues of clinical addictology. It is a risk factor for severe mental, behavioral, somatoneurological disorders, disability and mortality. Since the pathogenesis and clinical manifestations of dipsomania are complex, addictology uses comprehensive pharmacological and other treatments, mostly insufficiently effective. Objectives: Innovative improvement of relieving method for heavy drinking states in alcohol abusers aiming at rise of efficiency, reduction of side effects and complications. Methods: Valid clinical-diagnostic, laboratory, biochemical, electrophysiological, psychological (scaling, testing) methods of dipsomaniac alcohol dependence statistical identification. Results: A new way of relieving alcohol intoxication (patent, 41156, UA) using pharmacological therapy (detoxifying, general tonic, thymolytic, tranquilizing, neuroleptic) has been proposed, characterized by intramuscular 1 ml Galapril (Ukrainian analogue of international Haloperidol) 3-7 days, once-twice daily, carried out against the background of:) intravascular/transdermal laser therapy (0.63 µm wavelength, 2 mW radiation intensity, 30-40 min exposure, once daily for 3-5 procedure course), b) oral administration of sorbent Enterosgel (15 g single dose, three times daily 1.5-2 hours before or 2 hours after meals and taking medications, a course of 7-14 days). Membrane plasmapheresis is also pathogenetically grounded (patent 41156, UA). Conclusions: The treatment method was statistically significantly more effective compared to the conventional therapeutic approach. [ABSTRACT FROM AUTHOR]