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Your search keyword '"Folgiero, Valentina"' showing total 3 results
Start Over Author "Folgiero, Valentina" Topic acute myeloid leukemia
3 results on '"Folgiero, Valentina"'

1. Indoleamine 2,3-dioxygenase-1 (IDO1) expression by childhood acute myeloid leukemia restrains IFN-{gamma} production by T cells and may portend an unfavorable prognosis

Author

Rutella, Sergio, Folgiero, Valentina, Masetti, Riccardo, Pagliara, Daria, Caruso, Roberta, Vinti, Luciana, Moretta, Francesca, Pession, Andrea, and Locatelli, Franco

Subjects
IFN-{gamma}, 3-dioxygenase 1, Indoleamine 2, 3-dioxygenase 1 , regulatory T cells, acute myeloid leukemia, IFN-{gamma}, acute myeloid leukemia, regulatory T cells, Indoleamine 2
Published
2013

2. Indoleamine 2, 3-Dioxygenase-1 (IDO1) Is Expressed by a Subset of Childhood Acute Myeloid Leukemias and Restrains IFN-gamma Production by T Cells

Author

Folgiero, Valentina, Natale, Daniela, Pagliara, Daria, Caruso, Roberta, Vinti, Luciana, Coletti, Valentina, Moretta, Francesca, De Cristofaro, Raimondo, Locatelli, Franco, and Rutella, Sergio

Subjects
3-dioxygenase 1, acute myeloid leukemia, Indoleamine 2,3-dioxygenase 1, regulatory T cells, acute myeloid leukemia, regulatory T cells, Indoleamine 2
Published
2012

3. TIM-3/Gal-9 interaction induces IFNγ-dependent IDO1 expression in acute myeloid leukemia blast cells.

Author

Folgiero, Valentina, Cifaldi, Loredana, Li Pira, Giuseppina, Goffredo, Bianca Maria, Vinti, Luciana, and Locatelli, Franco

Subjects
*ACUTE myeloid leukemia, *GENE expression, *BONE marrow, *GENETIC regulation, *CANCER chemotherapy
Abstract

NK cells expressing TIM-3 show a marked increase in IFNγ production in response to acute myeloid leukemia (AML) blast cells that endogenously express Gal-9. Herein, we demonstrate that NK cell-mediated production of IFNγ, induced by TIM-3/Gal-9 interaction and released in bone marrow microenvironment, is responsible for IDO1 expression in AML blasts. IDO1-expressing AML blasts consequently down-regulate NK cell degranulation activity, by sustaining leukemia immune escape. Furthermore, the blocking of TIM-3/Gal-9 interaction strongly down-regulates IFNγ-dependent IDO1 activity. Thus, the inhibition of TIM-3/Gal-9 immune check point, which affects NK cell-dependent IFNγ production and the consequent IDO1 activation, could usefully integrate current chemotherapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2015
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