1. Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia
- Author
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Cao, Shu-Chun, Legerstee, Jeroen S, van Bellinghen, Marc, Lemiere, Jurgen, Sleurs, Charlotte, Segers, Heidi, Danckaerts, Marina, and Dierckx, Bram
- Subjects
NEUROPSYCHOLOGICAL OUTCOMES ,Social Sciences ,Experimental and Cognitive Psychology ,acute lymphoblastic leukemia ,NEUROCOGNITIVE OUTCOMES ,CRANIAL RADIATION ,SDG 3 - Good Health and Well-being ,Psychology, Multidisciplinary ,antineoplastic agents ,Psychology ,cancer ,WHITE-MATTER ANISOTROPY ,child ,neuropsychological tests ,Science & Technology ,LONG-TERM SURVIVORS ,survivors ,FARBER CANCER INSTITUTE ,intelligence ,COGNITIVE IMPAIRMENT ,Biomedical Social Sciences ,RANDOMIZED-TRIAL ,Social Sciences, Biomedical ,Psychiatry and Mental health ,Oncology ,adolescent ,adverse effects ,CHILDHOOD LEUKEMIA ,PEDIATRIC BRAIN-TUMORS ,Life Sciences & Biomedicine - Abstract
OBJECTIVE: This meta-analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post-treatment who were treated with either chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS: The databases Pubmed and PsychInfo were searched between 1-1-2000 and 31-12-2021. Data were analyzed using Comprehensive Meta-Analysis (version 2). RESULTS: Mean weighted intelligence after treatment was 100.2 (number of studies n = 51, 95% CI: 98.8-101.5). For CT-only, it was 100.8 (95% CI: 99.5-102.2) and for CTRT 97.8 (95% CI: 95.9-100.2). Compared to recruited healthy controls, treated children had on average lower IQ scores (n = 23, mean difference -7.8, 95% CI: -10.7 to -5.0, p
- Published
- 2023