1. Liver Transplantation for Dengue-induced Acute Liver Failure.
- Author
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Rajakumar, Akila, Gupta, Prateek, Rammohan, Ashwin, Devarajan, Vidya, Jothimani, Dinesh, Shanmugam, Naresh, Kaliamoorthy, Ilankumaran, and Rela, Mohamed
- Subjects
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LIVER transplantation , *LIVER failure , *VIRUS diseases , *TREATMENT effectiveness , *DISEASE management , *DENGUE hemorrhagic fever - Abstract
Although liver involvement has been observed in over two-third cases of dengue viral infection, less than 1% cases progress to dengue-related acute liver failure (D-ALF). Various aspects of management of this disease remain debated including the need and timing of liver transplantation (LT). Moreover, the outcomes of LT for D-ALF have been suboptimal. We present four contrasting cases of D-ALF, two managed with LT and the other two conservatively to highlight the management dilemmas concerning LT in D-ALF. Based on our 4 cases, we would consider dengue shock syndrome, multisystem involvement and neurological deficit not completely accounted for by the ALF as potential contraindications for LT. These would need to be revisited on a case-to-case basis till larger studies define objective selection criteria for LT in D-ALF. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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