6 results on '"Inaba, Shinji"'
Search Results
2. Isolated Negative Vessel Remodeling-Induced Myocardial Ischemia.
- Author
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Sakaue T, Inaba S, Morioka H, Sumimoto T, and Saito M
- Subjects
- Acute Coronary Syndrome diagnostic imaging, Acute Coronary Syndrome drug therapy, Adrenergic beta-1 Receptor Antagonists therapeutic use, Aged, Calcium Channel Blockers therapeutic use, Coronary Stenosis diagnostic imaging, Coronary Stenosis drug therapy, Coronary Vasospasm diagnostic imaging, Coronary Vasospasm drug therapy, Coronary Vessels diagnostic imaging, Coronary Vessels drug effects, Humans, Male, Non-ST Elevated Myocardial Infarction diagnostic imaging, Treatment Outcome, Acute Coronary Syndrome physiopathology, Coronary Stenosis physiopathology, Coronary Vasospasm physiopathology, Coronary Vessels physiopathology, Non-ST Elevated Myocardial Infarction physiopathology, Vascular Remodeling drug effects, Vasoconstriction drug effects
- Published
- 2020
- Full Text
- View/download PDF
3. Relationship between left main coronary artery plaque burden and nonleft main coronary atherosclerosis: results from the PROSPECT study.
- Author
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Shimizu T, Mintz GS, De Bruyne B, Farhat NZ, Inaba S, Cao Y, Marso SP, Weisz G, Serruys PW, Stone GW, and Maehara A
- Subjects
- Acute Coronary Syndrome pathology, Acute Coronary Syndrome surgery, Aged, Coronary Artery Disease pathology, Coronary Artery Disease surgery, Coronary Vessels pathology, Coronary Vessels surgery, Female, Humans, Male, Middle Aged, Percutaneous Coronary Intervention adverse effects, Predictive Value of Tests, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Acute Coronary Syndrome diagnostic imaging, Coronary Artery Disease diagnostic imaging, Coronary Vessels diagnostic imaging, Plaque, Atherosclerotic, Ultrasonography, Interventional
- Abstract
Objectives: Whether the severity of left main coronary artery (LMCA) disease reflects LMCA and overall coronary atherosclerotic burden is not known. We aimed to assess nonculprit LMCA disease characteristics and the relationship with atherosclerosis in the rest of the coronary arteries as well as patient outcomes., Patients and Methods: In the PROSPECT study, 697 patients with acute coronary syndromes underwent three-vessel gray-scale and radiofrequency intravascular ultrasound after percutaneous coronary intervention., Results: Overall, 552 patients with adequate LMCA imaging were compared according to LMCA plaque burden. The tertile with the highest plaque burden in the LMCA had the smallest LMCA minimum lumen area (17.4, 14.2, 10.5, lowest through highest tertiles, respectively, P<0.0001) and the greatest percent necrotic core volume (2.8, 5.6, 9.5%, lowest through highest tertiles, respectively, P<0.0001). Furthermore, the tertile with the highest plaque burden was also significantly associated with the highest overall non-LMCA percent atheroma volume within the major epicardial arteries (48.3, 49.2, 50.8%, lowest through highest tertiles, respectively, P<0.0001). After adjusting for patient background, the LMCA plaque burden was independently associated with non-LMCA percent atheroma volume (P=0.003). Of the three PROSPECT predictors of future nonculprit major adverse cardiac events (MACE) (minimum lumen area≤4 mm, plaque burden≥70%, and virtual histology thin-cap fibroatheroma), the tertile with the highest LMCA plaque burden had the highest number of patients with at least one of three PROSPECT predictors (P=0.03). In multivariable model, though total atheroma volume (per 1%) was an independent predictor of all MACE [hazard ratio (95% confidence interval)=1.06 (1.01-1.11), P=0.02] and strong trend for non-culprit-related MACE [hazard ratio (95% confidence interval)=1.06 (1.00-1.13), P=0.06], plaque burden at LMCA was not (all MACE, P=0.90, non-culprit-related MACE, P=0.85)., Conclusion: The severity of atherosclerosis in LMCA predicted the overall atherosclerotic plaque burden as well as the presence of high-risk plaques in the three major epicardial coronary arteries.
- Published
- 2018
- Full Text
- View/download PDF
4. Usefulness of Intravascular Ultrasound for Predicting Risk of Intraprocedural Stent Thrombosis.
- Author
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Morofuji T, Inaba S, Hitsumoto T, Takahashi K, Aisu H, Higashi H, Saito M, Ohshima K, Ikeda S, Hamada M, and Sumimoto T
- Subjects
- Adult, Aged, Aged, 80 and over, Aspirin administration & dosage, Clopidogrel, Humans, Japan epidemiology, Male, Middle Aged, Platelet Aggregation Inhibitors administration & dosage, Predictive Value of Tests, Retrospective Studies, Risk Assessment, Risk Factors, Sensitivity and Specificity, Thrombosis epidemiology, Ticlopidine administration & dosage, Ticlopidine analogs & derivatives, Acute Coronary Syndrome surgery, Myocardial Infarction surgery, Percutaneous Coronary Intervention adverse effects, Stents adverse effects, Thrombosis etiology, Ultrasonography, Interventional
- Abstract
Intraprocedural stent thrombosis (IPST) is a rare complication of percutaneous coronary intervention that leads to poor outcomes; however, the factors contributing to IPST remain largely unknown. Accordingly, we used intravascular ultrasound (IVUS) to examine the lesion characteristics in patients with IPST. We retrospectively analyzed 1,504 consecutive stent-implanted lesions in 1,324 patients (326 with ST-segment elevation myocardial infarction [STEMI], 403 patients with non-ST-segment elevation acute coronary syndrome [NSTE-ACS], and 595 patients with stable angina). Of these, IPST occurred in 5 patients during percutaneous coronary intervention (0.4% per patient; 3 with STEMI, 2 with NSTE-ACS). The IVUS characteristics of plaques that developed IPST were compared with those of controls without the evidence of IPST (non-IPST; n = 15) who were matched by age, gender, lesion location, and clinical presentation (STEMI, NSTE-ACS, or stable angina). All 5 lesions that led to IPST had ruptured plaques with positive remodeling and attenuation. Plaque rupture was also observed in 40% of the non-IPST group. Multiple plaque ruptures in the culprit lesion were more common in the IPST group (80% vs 7%; p <0.01). The maximum cavity area was larger in the IPST group than in the non-IPST group having plaque rupture (4.6 mm(2) [interquartile range, 4.3 to 6.5] vs 2.4 mm(2) [1.8 to 2.9]; p <0.01). In conclusion, we found using IVUS that multiple plaque ruptures with larger cavities more often evolved into IPST., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
5. Pseudoxanthoma elasticum resulting in acute coronary syndrome.
- Author
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Ono, Hiroki, Oshita, Akira, Inaba, Shinji, Kawamata, Moeko, Nakao, Yasuhisa, Uetani, Teruyoshi, Muto, Jun, Joko, Takeshi, and Kawakami, Hideo
- Abstract
Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder that causes elastic tissue degeneration in the skin, eyes, and cardiovascular system. Gastrointestinal bleeding and fundus hemorrhage are serious complications associated with PXE prognosis as well as cardiovascular involvement. This is a rare case of acute coronary syndrome in a PXE patient with high bleeding risk. Pseudoxanthoma elasticum (PXE) resulting in acute coronary syndrome (ACS) is rare. Given PXE patients are generally at very high bleeding risk, antithrombotic therapy as secondary prevention after ACS onset should be taken into full consideration. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Relationship between smaller calcifications and lipid-rich plaques on integrated backscatter-intravascular ultrasound
- Author
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Inaba, Shinji, Okayama, Hideki, Funada, Jun-ichi, Hashida, Hidetoshi, Hiasa, Go, Sumimoto, Takumi, Takata, Yasunori, Nishimura, Kazuhisa, Inoue, Katsuji, Ogimoto, Akiyoshi, Ohtsuka, Tomoaki, and Higaki, Jitsuo
- Subjects
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ATHEROSCLEROTIC plaque , *CALCIFICATION , *LIPIDS , *INTRAVASCULAR ultrasonography , *MULTIVARIATE analysis , *CORONARY disease , *ACUTE coronary syndrome - Abstract
Abstract: We evaluated the relationship between coronary calcification and plaque characteristics using integrated backscatter-intravascular ultrasound (IB-IVUS), focusing on spotty calcification. Seventy-two patients with culprit plaques containing spotty calcification were evaluated. The average degree of all the spotty calcifications (averaged arc) negatively correlated with the % lipid volume (LV) on IB-IVUS. Multivariate analysis showed the averaged arc was an independent predictor of % LV. Our observations suggest that smaller plaque calcifications are associated with lipid-rich characteristics in patients with a spotty calcification pattern. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
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