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To investigate the effects of Xiaoshuan Changrong capsule combined with argatroban on hemorheology and nerve injury in patients with acute cerebral infarction (ACI). 150 patients with ACI who were received in our hospital from January 2016 to December 2019 were selected, and they were randomly divided into control group (treated with conventional drugs and argatroban, 75 cases) and observation group (treated with conventional drugs, argatroban and Xiaoshuan Changrong capsule, 75 cases)by random number table method. The clinical efficacy, Barthel index, National Institutes of Health Stroke Scale (NIHSS) score, hemorheology and nerve injury indexes before and after treatment, and the occurrence of adverse drug reactions were compared between the two groups. The total effective rate in the observation group was higher than that in the control group (P＜0.05). Compared with the control group, Barthel index in the observation group after treatment was higher, and NIHSS score was lower (all P＜0.05). After treatment, fibrinogen, whole blood high / low shear viscosity and plasma viscosity in the observation group were lower than those in the control group (all P＜0.05). After treatment, the levels of serum neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100B protein in the observation group were lower than those in the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Xiaoshuan Changrong capsule combined with argatroban is effective in the treatment of ACI, and which can significantly improve the level of hemorheology and nerve injury indexes. [ABSTRACT FROM AUTHOR]