1. Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease
- Author
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Xiao-Juan Deng, Feng-Ying Quan, Ping Cheng, Chang-Qing Deng, Qian Xiao, Yao-Ping Zhu, Qi He, Guojun Chen, Yuan Li, Jian Wang, Wen-Hui Fan, and Xiao-Yan Xu
- Subjects
0301 basic medicine ,Glycation End Products, Advanced ,Male ,medicine.medical_specialty ,Pathology ,Enzyme-Linked Immunosorbent Assay ,Disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Glycation ,Alzheimer Disease ,Internal medicine ,mental disorders ,Activities of Daily Living ,medicine ,Dementia ,Humans ,Receptor ,Vascular dementia ,Aged ,Aged, 80 and over ,Analysis of Variance ,Receiver operating characteristic ,business.industry ,General Neuroscience ,Dementia, Vascular ,General Medicine ,Plasma levels ,Middle Aged ,medicine.disease ,030104 developmental biology ,ROC Curve ,Regression Analysis ,Female ,business ,Mental Status Schedule ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
A decreased plasma level of soluble form of the receptor for advanced glycation end products (sRAGE) in patients with Alzheimer's disease (AD) has been reported. However, no evidence has shown whether the sRAGE plasma level of AD patients may differentiate from other types of dementia.Our study assessed sRAGE concentrations in the following 121 individuals in Chongqing area: 36 patients with AD, 12 with vascular dementia (VaD), 14 with mixed dementia (MD), 24 with other dementia (OD) including Parkinson's disease dementia, frontotemporal dementia, paralytic dementia and 35 cognitively normal controls. The total plasma level of sRAGE was determined using sandwich ELISA method.sRAGE concentration in AD is significantly decreased compared with healthy controls. However, the receiver operating characteristic curve analysis of sRAGE between the AD and the control shows a low diagnostic accuracy.Our results demonstrate that sRAGE may assist the diagnosis of AD from normal individuals, but cannot differentiate AD from VaD, MD or OD.
- Published
- 2016