1. Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor.
- Author
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Ai Hua Zhang, Wen Liu, Nan Jiang, Qiang Xu, and Ren Xiang Tan
- Subjects
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AUTOIMMUNE diseases , *INFLAMMATION , *SPIRO compounds , *ACTIVATION (Chemistry) , *BIOSYNTHESIS , *INFLAMMASOMES , *CHEMICAL inhibitors - Abstract
Autoimmune and inflammatory diseases are associated with inappropriate activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, but suitable inhibitors against such improper activations remain scarce. Here, spirodalesol (1) from Daldinia eschscholzii was structurally characterized and is biosynthetically proposed as an NLRP3 inflammasome activation inhibitor with an unprecedented carbon skeleton. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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