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• Organic–inorganic hybrid hydrogel using alginate and UIO-66 AA was synthetized. • UIO 66 MOFs with different crystal sizes (600, 1500, and 2500 nm) were prepared. • The properties of the materials depend on the size and amount of UIO-66 crystals. • The hybrid materials showed reduced burst release and mechanical robustness. • Cytotoxicity screening indicated a promising biocompatible architecture. Herein, we report the preparation of an organic–inorganic hybrid hydrogel architecture using vinyl alginate and UiO-66 MOFs (metal-organic frameworks) modified with acrylic acid (AA) UiO-66AA. UiO-66 MOFs with different crystal sizes (600, 1500, and 2500 nm) were synthesized and the effect on the mechanical and transport properties of the resulting materials, such as water absorption capacity and drug release, were evaluated. HydroMOF showed higher water absorption capacity than the pure hydrogel and enhanced mechanical properties, which depend on crystal size and the amount of UiO-66AA MOF used. The initial release rate of drug (burst release) from hydroMOFs was lower when small-sized crystals or a small amount of large-sized crystals were used; thus these are essential in changing half-life values of release rates. Finally, the cytotoxicity screening successfully showed that hydroMOFs are promising biocompatible compounds proven to have the advantages of minimized burst release and mechanical robustness. [ABSTRACT FROM AUTHOR]

This paper reports the synthesis of a superabsorbent hybrid based on Arabic gum (AG) and a cross-linkable inorganic material for water dye absorption with enhanced mechanical properties. The inorganic material (MOF-UIO-66) was modified with acrylic acid (AA) using solvent-assisted ligand incorporation for further chemical hydrogelation with AG. This approach leads to a stable structure whose constituent phases are covalently bonded to each other. The mechanical properties and swelling degree were evaluated, and the effects of the pH, time, concentration, and reuse were investigated using absorption measures. The superabsorbent hydrogel (HAGMA, without MOF-UIO-66) absorbed 1014 g of water per 1 g of dry polymer, while the superabsorbent hybrid (AGMOF@AA) swelled hundreds times beyond its dry weight and maintained its three-dimensional shape. The elastic modulus of AGMOF@AA increased by 535% compared with that of HAGMA. The hybrid absorbs five times more energy until the fracture than the hydrogel. In the absorption process, AGMOF@AA showed a high amount of absorbed MB (768.03 mg g−1). Both samples exhibited pH-dependent absorption, and the Langmuir isotherm model correlated well with the experimental data. HAGMA and AGMOF@AA exhibited excellent regeneration capacity and were successfully used over five absorption-desorption cycles. • MOF-UIO-66/Arabic gum hybrid with enhanced mechanical properties was prepared. • The elastic modulus of hybrid increased by 535%, compared with pure material. • The hybrid absorbs five times more energy until the fracture. • In the absorption, the hybrid showed a high amount of absorbed blue methylene. • The proposed materials showed excellent regeneration capacity. [ABSTRACT FROM AUTHOR]