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Your search keyword '"Masaki Wakamatsu"' showing total 1 results
Start Over Author "Masaki Wakamatsu" Topic acrylamide
1 results on '"Masaki Wakamatsu"'

1. Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-adult rats

Author

Bunichiro, Ogawa, Yutaka, Nakanishi, Masaki, Wakamatsu, Yasunori, Takahashi, and Makoto, Shibutani

Subjects
Male, Doublecortin Domain Proteins, Acrylamide, Neural Stem Cells, Neurogenesis, Neuronal Outgrowth, Animals, Apoptosis, Toxicology, Hippocampus, Rats
Abstract

Acrylamide (AA) is a neurotoxicant that causes synaptic impairment in distal axons. We previously found that developmental exposure to AA decreased proliferation of late-stage neural progenitor cells (NPCs) in the hippocampal neurogenesis of the dentate gyrus (DG) in rats. To investigate whether hippocampal neurogenesis is similarly affected by AA exposure in a general toxicity study, AA was administered to 7-week-old male rats via oral gavage at dosages of 0, 5, 10, and 20 mg/kg for 28 days. In the subgranular zone (SGZ) and granule cell layer, AA decreased the densities of doublecortin-positive

Published
2022

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