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Background: Commonly affecting the face, chest, and back, acne is an inflammatory disorder that can be treated with a variety of modalities, with laser treatment remaining a key option for scar treatment. This study aimed to compare the efficacy and safety of topical timolol after fractional CO2 versus fractional laser alone in the treatment of acne scars. Patients & Methods: This Interventional comparative study was carried out on 62 patients different skin types suffering from mild, moderate and severe facial acne scars, patients were divided into 2 groups; Group one: 31 patients were treated by topical timolol maleate 0.5% after fractional laser twice daily for seven days to be repeated every two weeks until complete response or for maximum of six sessions. Group two: 31 patients were treated by fractional CO2 laser alone every two weeks until complete response or for maximum of six sessions. Results: There was highly statistically significant improvement post acne scar after application of Timolol with LASER (P< 0.001). Moreover, there was statistically significant improvement post acne scar after application of Timolol with LASER. The findings suggest that the combination of topical timolol maleate with fractional CO2 laser therapy may offer enhanced benefits compared to CO2 laser treatment alone. This is evident in the observed improvements in acne scar outcomes, such as texture, pigmentation, and overall skin appearance. Conclusion: Applying topical 0.5% TM twice a day could result in a noticeable improvement, enhances the function of the skin's barrier and may encourage re-epithelialization following laser treatments. [ABSTRACT FROM AUTHOR]