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Acne scars can greatly impact patient quality of life. While treatment options have included microneedling, the recent addition of platelet-rich plasma (PRP) to this regimen has led to an increased popularity of combination treatment. Here, we aimed to review the efficacy of microneedling and PRP therapies and review the literature on combination treatment for acne scars. [ABSTRACT FROM AUTHOR]

Introduction: With the rising popularity of Isotretinoin for acne vulgaris treatment, the interest in knowing the effect of oral Isotretinoin on endocrine function and the metabolic processes has increased considerably. Aim: To study the effect of Isotretinoin on serum thyroid hormone levels in acne patients and to study side effects of Isotretinoin if any. Materials and Methods: In this quasi experimental study from September 2018-August 2019, using purposive method, 30 patients (Twenty males and Ten females) between age group 15-30 years-old having grade 3 (20 patients) and 4 (10 patients) acne vulgaris (according to standard system of grading) were enrolled and were started on oral capsule Isotretinoin 0.5 mg/kg/day for at least three months. A baseline thyroid profile which includes serum Triiodothyronine (T3), serum Thyroxine (T4) and Thyroid Stimulating Hormone (TSH) was performed on all subjects before and after three months of continued treatment. p-value <0.05 was considered as significant. Results: After three months of continuous oral Isotretinoin administration, it was observed that serum T3 and T4 values were raised while serum TSH was slightly reduced as compared to baseline values but the difference was not statistically significant. It was also observed that lip cheilitis was the most common side effect manifesting in 28 out of 30 patients. Conclusion: In the study, minor alteration in thyroid profile was observed but the difference was statistically not significant. Thus, it can be concluded that Isotretinoin can be safely given upto three months without any disturbance in thyroid function tests. [ABSTRACT FROM AUTHOR]

A 44 year old female patient presented with multiple, painful, relapsing, nodules, plaques with sinuses discharging pus and scars in apocrine gland bearing region since past 17 years. These lesions were clinically and histopathologically suggestive of hidradenitis suppurativa. Our patient was not aware about the flexural pigmentary lesions, comedones and pitted scars which were also clinically and histopathologically suggestive of Dowling--Degos disease. We are reporting a rare interesting association of Dowling Degos disease and hidradenitis suppurativa which is not reported in Indian literature till date. [ABSTRACT FROM AUTHOR]