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The article titled "Commentary on 'Histopathologic analysis of hyaluronic acid composite solution following intravascular injection: Variability and safety'" by Zhang et al. provides valuable insights into the behavior of hyaluronic acid fillers when injected intravascularly and the impact of product rheology on the resulting injury. The authors conducted a clinical and histopathological study using a rat model and found that non-crosslinked hyaluronic acid filler dispersed over time without causing ischemic flap injury. This is in contrast to their previous study in 2019, which showed that crosslinked hyaluronic acid gel resulted in prolonged occlusion and ischemic necrosis. The study also analyzed histological photographs to quantify the fragmentation and clearance of the fillers over time. The findings contribute to our understanding of the behavior of hyaluronic acid fillers in arterial networks and the potential risks associated with their use. [Extracted from the article]