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Your search keyword '"Yazıcı, Cevat"' showing total 4 results
Start Over Author "Yazıcı, Cevat" Topic acetylcysteine
4 results on '"Yazıcı, Cevat"'

1. Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy.

Author

Somdaş MA, Güntürk İ, Balcıoğlu E, Avcı D, Yazıcı C, and Özdamar S

Subjects
Acetylcysteine pharmacology, Animals, Antioxidants pharmacology, Apoptosis, Cochlea drug effects, Cochlea pathology, Disease Models, Animal, Evoked Potentials, Auditory, Brain Stem, Hair Cells, Auditory, Outer drug effects, Hair Cells, Auditory, Outer pathology, Hearing Tests, Male, Microscopy, Electron, Scanning, Ototoxicity prevention & control, Protective Agents pharmacology, Rats, Wistar, Signal-To-Noise Ratio, Stereocilia drug effects, Stereocilia pathology, Acetylcysteine administration & dosage, Antineoplastic Agents adverse effects, Antioxidants administration & dosage, Cisplatin adverse effects, Ototoxicity etiology, Protective Agents administration & dosage
Abstract

Introduction: Ototoxicity is a health problem appearing after powerful treatments in serious health conditions. It is sometimes inevitable when treatment of the serious disease is required. Cisplatin is an antineoplastic agent which was investigated previously to reveal increased nitrogen and reactive oxygen radicals that damages hair cells, resulting in ototoxicity. N-acetylcysteine, previously shown to decrease ototoxicity caused by different agents, is known to be a powerful in vitro antioxidant. Probably N-acetylcysteine, in addition to its antioxidant effect, blocks a cascade where reactive oxygen species result in apoptosis in the cochlea., Objectives: The possible preventive effect of N-acetylcysteine in cisplatin ototoxicity was studied with auditory brain stem responses, otoacoustic emissions, and histopathological investigation of the cochlea in a scanning electron microscopy., Methods: This study was conducted on 21 Wistar Albino rats in four groups. 1mL/kg/day three times in total intraperitoneal (i.p.) Saline (n=5), 500mg/kg/day i.p. three times in total N-acetylcysteine (n=5), i.p. 15mg/kg cisplatin alone (single dose) (n=5) and i.p. 15mg/kg cisplatin plus 500mg/kg/day N-acetylcysteine (n=6) were administered. The rats were anesthetized to study the hearing tests before and after the experiment. The rats were sacrificed to investigate the cochleas by scanning electron microscopy., Results: Auditory brain stem responses and otoacoustic emissions values were attenuated in the cisplatin group. The group that received N-acetylcysteine in addition to cisplatin had better auditory brain stem responses thresholds and otoacoustic emissions. The samples obtained from the cisplatin group showed surface irregularities, degeneration areas, and total or partial severe stereocilia losses. The changes were milder in the cisplatin+N-acetylcysteine group., Conclusion: Cisplatin ototoxicity can be detected by auditory brain stem responses and otoacoustic emissions testing in rats. N-acetylcysteine may protect the cochlear cells from histopathological changes. We concluded that N-acetylcysteine given 4h after cisplatin injection has a potential otoprotective effect against cisplatin ototoxicity. which suggests it could be used in clinical trials., (Copyright © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)

Published
2020
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2. Effect of N-acetylcysteine on cisplatin induced apoptosis in rat kidney.

Author

Güntürk, Inayet, Seydel, G. Şeyda, Dağlı, Fatma, Yay, Arzu, Yazıcı, Cevat, and Köse, Kader

Subjects
CISPLATIN, ACETYLCYSTEINE, APOPTOSIS inhibition, BLOOD urea nitrogen, LABORATORY rats
Abstract

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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3. Pirrolize Protein Behçet Hastalığında Yeni Bir Oksidatif Stres Belirteci Olabilir mi?

Author

Kaya, Seval, Köse, Kader, Yazıcı, Cevat, Utaş, Serap, and Borlu, Murat

Subjects
BEHCET'S disease, ANTIOXIDANTS, PLACEBOS, RANDOMIZED controlled trials, PROTEINS, OXIDATIVE stress
Abstract

Copyright of Erciyes Medical Journal / Erciyes Tip Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010

4. Deneysel sisplatin nefrotoksisitesine karşı n-asetilsisteinin etkisi

Author

Güntürk, İnayet, Yazıcı, Cevat, and Biyokimya Anabilim Dalı

Subjects
Inflammation, Toxicity, Oxidative stress, Biyokimya, Animal experimentation, Toxicity tests, Cisplatin, Nephrotoxicity, Biochemistry, N-acetylcysteine, Acetylcysteine, Rats
Abstract

DENEYSEL SİSPLATİN NEFROTOKSİSİTESİNE KARŞI N-ASETİLSİSTEİNİN ETKİSİ İnayet GÜNTÜRKErciyes Üniversitesi, Sağlık Bilimleri EnstitüsüBiyokimya Anabilim Dalı Doktora Tezi, Ocak 2018Danışman: Prof. Dr. Cevat YAZICIKISA ÖZETSisplatin solid organ tümörlerinin tedavisinde yaygın olarak kullanılan oldukça etkili kemoterapötik bir ajandır. En yaygın görülen ve klinik kullanımını sınırlayan yan etkisi nefrotoksisitedir. Son yıllarda, nefrotoksisite gelişimine katılan en önemli mekanizmaların oksidatif stres ve enflamasyon olduğu öne sürülmektedir.N-asetilsistein (NAC), doğrudan radikal yakalayıcı olarak ve/veya hücre içi redükte glutatyon düzeylerini artırarak etki gösteren bir antioksidandır. Bu çalışmada, NAC'ın ratlarda sisplatinle indüklenen nefrotoksisite üzerine etkilerinin araştırılması amaçlandı. Bu amaçla, ratlar her grupta sekiz rat olmak üzere, dört gruba ayrıldı: KONT, NAC-250, CP ve CP+NAC. Sisplatin uygulaması intraperitoneal (ip) tek doz, 10 mg/kg rat ağırlığı ve NAC uygulaması ip, ardışık 3 gün, 250 mg/kg rat ağırlığı şeklinde yapıldı. Nefrotoksisite gelişimi plazma BUN, kreatinin ve idrar mikroalbümin seviyeleri ile belirlendi. Ayrıca böbrek dokularında histolojik değerlendirme yapılarak da nefrotoksisite tanısı desteklendi. Kan ve doku örneklerinde miyeloperoksidaz (MPO), nükleer faktör-kappa B (NF-B) ve `high mobility group box-1` (HMGB-1) seviyeleri ölçüldü. Sisplatinin plazma ve doku örneklerinde MPO, NF-B ve HMGB-1 düzeyleri üzerinde etkili olmadığı, ancak NAC'ın MPO ve HMGB-1 doku seviyelerini anlamlı derecede artırdığı gözlendi. Bununla birlikte, NAC böbreklerdeki fonksiyonel ve histolojik değişiklikleri iyileştirdi. Sonuç olarak, bu deneysel modelde sisplatin nefrotoksisitesine enflamasyonun katkısının sınırlı olduğu söylenebilir. Bununla birlikte, farklı kanser hücre hatlarında çok yönlü ve birbirine zıt etkiler gösterebilen NF-B ve HMGB-1'in seviyelerini etkilemeksizin, böbrek fonksiyonlarını iyileştirebilen NAC'ın; tüm kanser tiplerinde, kemoterapi etkinliğini değiştirmeksizin sisplatin yan etkilerinin azaltılmasında güvenle kullanılabileceği öne sürülebilir.. Anahtar kelimeler: Rat, sisplatin, oksidatif stres, enflamasyon, N-asetilsistein THE EFFECT OF N-ACETYLCYSTEINE AGAINST EXPERIMENTALLY INDUCED CISPLATIN NEPHROTOXICITY İnayet GÜNTÜRK Erciyes University, Graduate School of Health Sciences, Department of Biochemistry, Doctoral Dissertation, January 2018Supervisor: Prof. Dr. Cevat YAZICIABSTRACTCisplatin is a widely used and highly effective chemotherapeutic agent used in the treatment of solid organ cancers. The most common side effect that limits its clinical usage is nephrotoxicity. In recent years it has been suggested that the most important mechanisms that contribute to nephrotoxicity are oxidative stress and inflammation. N-acetylcysteine (NAC) is an antioxidant, that acts directly as a free radical scavengers and/or increase intracellular reduced glutathione. In the present study, the effects of NAC is investigated, on cisplatin induced nephrotoxicity in rats. For this purpose, rats were divided into four groups each group including eight rats: CONT, NAC-250, CP, CP+NAC. Cisplatin was administrated intraperitoneally (ip), single dose,10 mg/kg body weight and NAC was administrated ip, 250 mg/kg body weight for three consequitive days. Nephrotoxicity was determined by plasma BUN, creatinine and urine microalbumin levels. Nephrotoxicity was also supported by histological analysis in kidney tissue samples. In blood and tissue samples myeloperoxidase (MPO), nuclear factor-kappa B (NF-B) and high mobility group box-1 (HMGB-1) levels were measured. It was found out that cisplatin was not effective on MPO, HMGB-1 and NF-B levels in blood and tissue samples, however, NAC elevated MPO and HMGB-1 levels significantly. Nevertheless NAC ameliorated histological and functional changes in kidney tissues. In conclusion, it can be said that inflammation has limited effect on cisplatin nephrotoxicity in this experimental design. However NAC, which can ameliorate renal function without effecting the levels of NF-kB and HMGB-1 that have versatile and opposite effects on different cancer cell lines, is suggested to be safely used to reduce the side effects of cisplatin without altering chemotherapy efficacy for all cancer types.Keywords: Rats, cisplatin, oxidative stress, inflammation, N-acetylcysteine 116

Published
2018

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