1. N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure.
- Author
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Eisen JS, Koren G, Juurlink DN, and Ng VL
- Subjects
- Decontamination, Female, Humans, Infant, Liver Failure pathology, Treatment Outcome, Acetylcysteine therapeutic use, Antidotes therapeutic use, Clove Oil poisoning, Free Radical Scavengers therapeutic use, Liver Failure etiology, Liver Failure therapy
- Abstract
We present a 3-month-old female who developed fulminant hepatic failure after ingesting less than 8 mL of clove oil. Initial treatment involved gastrointestinal decontamination, supportive measures, and admission to hospital. She subsequently developed fulminant hepatic failure and was treated with intravenous N-acetylcysteine (N-AC) according to a protocol used for acetaminophen poisoning. Over the next 72 h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N-AC therapy are reviewed.
- Published
- 2004
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