1. Peptidergic input to immunohistochemically-identified Renshaw cells
- Author
-
Matthew J. Roller, Patrick A. Carr, and Richard A. Zaruba
- Subjects
Male ,Interneuron ,Calcitonin Gene-Related Peptide ,Substance P ,Biology ,Calcitonin gene-related peptide ,Receptors, Nicotinic ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,medicine ,Animals ,Molecular Biology ,Acetylcholine receptor ,Neurons ,Renshaw cell ,General Neuroscience ,Lumbosacral Region ,Immunohistochemistry ,Rats ,Nicotinic agonist ,medicine.anatomical_structure ,chemistry ,Spinal Cord ,Calcitonin ,Neurology (clinical) ,Neuroscience ,Acetylcholine ,Developmental Biology ,medicine.drug - Abstract
Peptidergic influences on Renshaw cells were assessed in rat using gephyrin-immunoreactivity, as a Renshaw cell specific marker, in combination with substance P, calcitonin gene-related peptide- and nicotinic acetylcholine receptor-immunolabelling. An average of 3.9 substance P-, and 8.1 calcitonin gene-related peptide-, and 16.3 nicotinic acetylcholine receptor-immunoreactive close contacts or puncta were observed per Renshaw cell. Most appositions were somatic. These results provide neuroanatomical support for the peptidergic modulation of Renshaw cells.
- Published
- 2001