1. Synthesis and Biological Activity of 2',3'-iso-Aryl-abscisic Acid Analogs.
- Author
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Wan C, Wang M, Yang D, Han X, Che C, Ding S, Xiao Y, and Qin Z
- Subjects
- Abscisic Acid metabolism, Arabidopsis metabolism, Germination, Lactuca metabolism, Molecular Structure, Oryza metabolism, Plant Growth Regulators chemical synthesis, Plant Growth Regulators metabolism, Seedlings metabolism, Seeds metabolism, Abscisic Acid analogs & derivatives, Abscisic Acid chemical synthesis
- Abstract
2',3'- iso -Benzoabscisic acid ( iso -PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and replacing the ring with heterocycles. Thus, 16 novel analogs of iso -PhABA were synthesized and screened with three bioassays, Arabidopsis and lettuce seed germination and rice seedling elongation. Some of them, i.e., 2',3'- iso -pyridoabscisic acid ( iso -PyABA) and 2',3'- iso -franoabscisic acid ( iso -FrABA), displayed good bioactivities that closed to iso -PhABA and natural (+)-ABA. Some others, for instance, substituted- iso -PhABA, exhibited certain selectivity to different physiological process when compared to iso -PhABA or (+)-ABA. These analogs not only provided new candidates of ABA-like synthetic plant growth regulators (PGRs) for practical application, but also new potential selective agonist/antagonist for probing the specific function of ABA receptors., Competing Interests: The authors declare no conflict of interest.
- Published
- 2017
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