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Introduction: Recent developments in our understanding of facial ageing have led to a greater appreciation of the part played by dynamic wrinkles. Botulinum toxin is increasingly used to lessen hyperdynamic muscular activity and to rejuvenate the ageing face. Materials and method: A group of international experts convened to consider the literature and, in the light of their own clinical experience, discuss the optimal uses of abobotulinum toxin A (aboTA ) for myomodulation. To assist doctors, the international expert group here presents consensus guidelines for the use of AboTA in various clinical indications. Discussion: To achieve optimal results, the clinician requires a detailed understanding of facial anatomy, correct dilution technique, injection procedure and aftercare. Conclusions: AboTA may be used to rejuvenate the face and other areas. AboTA treatment is effective, safe, and relatively easy to perform and has high patient satisfaction. Duration of action is up to 5 1/2 months. [ABSTRACT FROM AUTHOR]