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Your search keyword '"Konopistseva LA"' showing total 3 results
Start Over Author "Konopistseva LA" Topic abnormalities, drug-induced
3 results on '"Konopistseva LA"'

1. [The role of the maternal genotype in the realization of the embryotoxic activity of teratogens].

Author

Chebotar' NA, Konopistseva LA, Ignat'eva TV, Golinskiĭ GF, Puchkov VF, and Dyban AP

Subjects
2,2'-Dipyridyl administration & dosage, Abnormalities, Drug-Induced etiology, Anemia, Iron-Deficiency chemically induced, Anemia, Iron-Deficiency complications, Anemia, Iron-Deficiency genetics, Animals, Ethanol toxicity, Female, Genome, Genotype, Male, Plasmids administration & dosage, Pregnancy, Pregnancy Complications etiology, Rats, Sodium Salicylate toxicity, Abnormalities, Drug-Induced genetics, Embryo, Mammalian drug effects
Abstract

Against the background of the induced iron deficit ethanol (6.4 g/kg) causes aggravation of the embryolethal effect and anomalies in 15% of embryos in 14-day pregnant rats. Changes in the genome of rat males and females after the injection of the plasmid with a foreign gene at the stage of two pronuclei and the subsequent crossing with intact animals account for the increase in sensitivity of embryos to subteratogenic doses of sodium salicilate. The maternal organism disturbances have a more pronounced effect than the paternal ones.

Published
1994

2. [The mechanisms of the teratogenic action of alcohol].

Author

Chebotar' NA and Konopistseva LA

Subjects
2,2'-Dipyridyl toxicity, Abnormalities, Drug-Induced pathology, Anemia, Iron-Deficiency chemically induced, Anemia, Iron-Deficiency pathology, Animals, Disulfiram toxicity, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Mammalian drug effects, Embryonic and Fetal Development drug effects, Female, Fetus drug effects, Male, Pregnancy, Rats, Time Factors, Abnormalities, Drug-Induced etiology, Ethanol toxicity
Abstract

Under study was the influence of different doses and methods of administration of ethanol on embryogenesis of rats and the effect of some shifts in homeostasis of a female rat on a manifestation of teratogenic effect of ethanol. Embryogenesis of rats is resistant to action of ethanol and acetaldehyde. Shift in the acid-base balance to the acid side is not thought to be determining in the mechanism of the appearance of the fetal alcohol syndrome, while the embryotoxic effect of ethanol manifests itself against the background of an iron-deficient state of the maternal organism.

Published
1993

3. [Alcohol-drug interaction in rat embryogenesis: the effect of separate and combined action of sodium salicylate and ethanol].

Author

Chebotar' NA, Tikhodeeva II, Konopistseva LA, Dzhandzhaliia AM, and Puchkov VF

Subjects
Animals, Drug Synergism, Ethanol administration & dosage, Female, Gestational Age, Pregnancy, Rats, Sodium Salicylate administration & dosage, Abnormalities, Drug-Induced, Ethanol adverse effects, Fetal Death chemically induced, Sodium Salicylate adverse effects
Abstract

A combined administration of sodium salicylate and ethanol to female rats in threshold embryotoxic doses on the 9th, 10th, 12th and 13th days of pregnancy results in a sharp increase of embryolethal and teratogenic effects. The embryotoxic effect of sodium salicylate and ethanol at their combined injection exceeds the summational embryotoxic effect at the separate action of the preparations. The spectrum of malformations after their combined effect does not differ from that induced with sodium salicylate.

Published
1988

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