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Your search keyword '"Lipka, D. B."' showing total 1 results
Start Over Author "Lipka, D. B." Topic abl1 gene
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1. Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells.

Author

Wagner, M-C, Dziadosz, M, Melo, J V, Heidel, F, Fischer, T, and Lipka, D B

Subjects
APOPTOSIS, CHRONIC myeloid leukemia, KINASES, CELL death, ABL1 gene
Abstract

The article presents a study which shows the influence of nilotinib on intracellular accumulation and induction of apoptosis in chronic myeloid leukemia (CML). Ba/ F3-BCR-ABL cells were treated with nilotinib and the effects of ABC-transporter expression on apoptosis upon HD-TKI pulse-exposure was investigated in the study. Results reveal that intracellular TKI retention upon nilotinib pulse-exposure translates into prolonged inhibition of BCR-ABL kinase, resulting to induction of apoptosis.

Published
2013
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