1. Carnosic acid.
- Author
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Birtić S, Dussort P, Pierre FX, Bily AC, and Roller M
- Subjects
- Abietanes isolation & purification, Animals, Anti-Infective Agents isolation & purification, Antioxidants isolation & purification, Chromatography, High Pressure Liquid, Humans, Mice, Molecular Structure, Plant Leaves chemistry, Rats, Rosmarinus classification, Sheep, Abietanes chemistry, Abietanes pharmacology, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Rosmarinus chemistry, Salvia chemistry
- Abstract
Carnosic acid (salvin), which possesses antioxidative and antimicrobial properties, is increasingly exploited within the food, nutritional health and cosmetics industries. Since its first extraction from a Salvia species (∼70 years ago) and its identification (∼50 years ago), numerous articles and patents (∼400) have been published on specific food and medicinal applications of Rosmarinus and Salvia plant extracts abundant in carnosic acid. In contrast, relevant biochemical, physiological or molecular studies in planta have remained rare. In this overview, recent advances in understanding of carnosic acid distribution, biosynthesis, accumulation and role in planta, and its applications are summarised. We also discuss the deficiencies in our understanding of the relevant biochemical processes, and suggest the molecular targets of carnosic acid. Finally, future perspectives and studies related to its potential roles are highlighted., (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2015
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