We consider the Dirac operators on R n , n ≥ 2 with singular potentials 1 D A , Φ , m , Γ δ Σ = D A , Φ , m + Γ δ Σ where 2 D A , Φ , m = ∑ j = 1 n α j - i ∂ x j + A j + α n + 1 m + Φ I N is a Dirac operator on R n with the variable magnetic and electrostatic potentials A = (A 1 ,... , A n) and Φ , and the variable mass m. In formula (2) α j are the N × N Dirac matrices, that is α j α k + α k α j = 2 δ jk I N , I N is the unit N × N matrix, N = 2 n + 1 / 2 , Γ δ Σ is a singular delta-type potential supported on a uniformly regular unbounded C 2 - hypersurface Σ ⊂ R n being the common boundary of the open sets Ω ± . Let H 1 (Ω ± , C N) be the Sobolev spaces of N - dimensional vector-valued distributions u on Ω ± , and H 1 (R n ╲ Σ , C N) = H 1 (Ω + , C N) ⊕ H 1 (Ω - , C N). We associate with the formal Dirac operator D A , Φ , m , Γ δ Σ the interaction (transmission) operator D A , Φ , m , B Σ = D A , Φ , m , B Σ defined by the Dirac operator D A , Φ , m on H 1 (R n ╲ Σ , C N) and the interaction condition B Σ : H 1 (R n B A , m , Φ , B Σ , C N) → H 1 / 2 (Σ , C N) associated with the singular potential. The main goal of the paper is to study the Fredholm property of the operators D A , Φ , m , B Σ for some non-compact C 2 -hypersurfaces. [ABSTRACT FROM AUTHOR]