1. JC VIRAL REACTIVATION IN A PEDIATRIC PATIENT WITH CROHN'S DISEASE
- Author
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Anna, Bellizzi, Barucca, V., Giovanni Di Nardo, Daniela, Fioriti, Fioriti, F., Iebba, Valerio, Serena, Schippa, Maria Pia Conte, Proietti Checchi, M., Checchi, M. P., Colosimo, M. T., Salvatore, Cucchiara, Salvatore, Oliva, Fernanda, Chiarini, Valeria Antonietta Pietropaolo, Bellizzi, Anna, Barucca, V., Di Nardo, Giovanni, Fioriti, Daniela, Fioriti, F., Iebba, Valerio, Schippa, Serena, Pia Conte, Maria, Proietti Checchi, M., Checchi, M. P., Colosimo, M. T., Cucchiara, Salvatore, Oliva, Salvatore, Chiarini, Fernanda, and Antonietta Pietropaolo, Valeria
- Subjects
5-asa ,jcv ,5-aminosalicylic acid (5-asa) ,pml ,crohn's disease (cd) ,crohn's disease ,jcv reactivation - Abstract
This is a report concerning human polyomavirus JC (JCV) reactivation in a pediatric patient with Crohn's disease (CD) during the treatment with 5-aminosalicylic acid (5-ASA), a non-steroidal anti-inflammatory drug (NSAID). We examined 9 bioptic samples from three different bowel districts (ileum, cecum, rectum) of this child. These samples were analyzed by Quantitative PCR (Q-PCR) to investigate the presence of JCV DNA. JCV DNA was detected in one rectum biopsy taken two months after 5-ASA treatment. Although our result must be validated in a larger group of subjects and with a longer follow-up period, it underlines the importance of JCV monitoring in CD patients.
- Published
- 2010