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With the 2030 Agenda for Sustainable Development, the United Nations have established a catalog of 17 Sustainable Development Goals (SDGs) to achieve a better and more sustainable future for all by 2030. One important aspect, formulated as Goal 6, is ensuring the availability and sustainable management of water and sanitation for all. Achieving SDG6 represents a challenge for planning, governance, and water management, especially in prosperous water-scarce regions, where water demand rises steadily and outgrows sustainable supply. Using the example of the catchment area of the Río Lurín in Lima, Peru, the TRUST project demonstrated how interdisciplinary and transdisciplinary approaches could contribute to meeting the water management challenges that are related to achieving SDG 6 in prosperous regions facing water scarcity. The approaches cover the closely interlinked domains water resources, water use, and water management. For each domain, we set up a comprehensive data base, conducted local analyses, and developed integrated concepts taking the river basin perspective into account. The concepts covered drinking water supply, safe wastewater treatment and disposal, and water reuse. They were developed in close cooperation with local actors and national authorities. The methods and tools can be transferred to other regions of the world with similar challenges. This TRUST Report is intended as a manual to help decision-makers and water management professionals to develop and implement locally adapted solutions for sustainable water management.