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Your search keyword '"MESH: Pathology, Molecular"' showing total 3 results
Start Over Descriptor "MESH: Pathology, Molecular" Topic 3. good health
3 results on '"MESH: Pathology, Molecular"'

1. The 2021 WHO classification of tumors of the central nervous system: A summary

Author

Andreas von Deimling, Arie Perry, Ho Keung Ng, David N. Louis, David W. Ellison, Dominique Figarella-Branger, Guido Reifenberger, Riccardo Soffietti, Cynthia Hawkins, Pieter Wesseling, Daniel J. Brat, Stefan M. Pfister, Ian A. Cree, Pathology, CCA - Imaging and biomarkers, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service d'Anatomie Pathologique et de Neuropathologie [Hôpital de la Timone - CHU - APHM], and Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)

Subjects
Central Nervous System, Cancer Research, diagnosis, WHO Classification Summary, [SDV]Life Sciences [q-bio], MESH: World Health Organization, MESH: Central Nervous System Neoplasms, Central Nervous System Neoplasms, 0302 clinical medicine, Pathology, Medicine, Pathology, Molecular, Cancer, 0303 health sciences, Brain, 3. Good health, medicine.anatomical_structure, Oncology, classification, 030220 oncology & carcinogenesis, brain tumor, Central nervous system, Oncology and Carcinogenesis, Brain tumor, World Health Organization, central nervous system, Humans, brian tumor, 03 medical and health sciences, MESH: Brain, Rare Diseases, Taxonomy (general), MESH: Central Nervous System, CNS TUMORS, Oncology & Carcinogenesis, Letters to the Editor, Grading (tumors), 030304 developmental biology, MESH: Pathology, Molecular, MESH: Humans, business.industry, Neurosciences, Molecular, medicine.disease, Brain Disorders, Brain Cancer, Neurology (clinical), Who classification, business, Neuroscience
Abstract

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors. Building on the 2016 updated fourth edition and the work of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy, the 2021 fifth edition introduces major changes that advance the role of molecular diagnostics in CNS tumor classification. At the same time, it remains wedded to other established approaches to tumor diagnosis such as histology and immunohistochemistry. In doing so, the fifth edition establishes some different approaches to both CNS tumor nomenclature and grading and it emphasizes the importance of integrated diagnoses and layered reports. New tumor types and subtypes are introduced, some based on novel diagnostic technologies such as DNA methylome profiling. The present review summarizes the major general changes in the 2021 fifth edition classification and the specific changes in each taxonomic category. It is hoped that this summary provides an overview to facilitate more in-depth exploration of the entire fifth edition of the WHO Classification of Tumors of the Central Nervous System.

Published
2021
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2. Molecular diagnosis of polycystic echinococcosis due to Echinococcus vogeli in a Paraguayan immigrant in Argentina

Author

Laurence Millon, Arnault Cazorla, Marcelo Amante, M. L. Pestalardo, Solange Bresson-Hadni, J. Alvarez Rodriguez, Frédéric Grenouillet, Bernardo Frider, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de parasitologie et mycologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Parasitologie-Mycologie CHU Besançon, and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon )

Subjects
Male, MESH: Histocytochemistry, Pathology, MESH : Pathology, Molecular, MESH : Argentina, MESH : Aged, MESH: Echinococcus, Case Reports, MESH : Blotting, Western, MESH: Molecular Diagnostic Techniques, MESH : Echinococcosis, 0302 clinical medicine, Liver tissue, MESH : Tomography, X-Ray Computed, Molecular diagnostic techniques, MESH : Echinococcus, MESH: Animals, Pathology, Molecular, MESH: Paraguay, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, MESH: Aged, MESH: Immunoglobulin G, 0303 health sciences, biology, Histocytochemistry, MESH: Argentina, MESH : Paraguay, Echinococcosis, MESH: Emigrants and Immigrants, 3. Good health, Liver, Molecular Diagnostic Techniques, MESH: Tomography, X-Ray Computed, Microbiology (medical), Radiography, Abdominal, medicine.medical_specialty, MESH : Immunoglobulin G, MESH : Male, 030231 tropical medicine, Blotting, Western, Antibodies, Helminth, Argentina, Emigrants and Immigrants, Parasitic infection, Echinococcus vogeli, 03 medical and health sciences, MESH: Echinococcosis, MESH: Antibodies, Helminth, parasitic diseases, medicine, Animals, Humans, MESH: Blotting, Western, Molecular identification, Aged, MESH : Antibodies, Helminth, MESH: Pathology, Molecular, MESH: Humans, 030306 microbiology, business.industry, MESH : Humans, MESH : Liver, MESH : Radiography, Abdominal, biology.organism_classification, medicine.disease, Virology, MESH: Male, Echinococcus, Tomography x ray computed, Paraguay, Immunoglobulin G, MESH : Emigrants and Immigrants, MESH: Radiography, Abdominal, MESH : Animals, MESH : Histocytochemistry, business, Tomography, X-Ray Computed, MESH : Molecular Diagnostic Techniques, MESH: Liver
Abstract

Polycystic echinococcosis due to Echinococcus vogeli is a rare parasitic infection that occurs in rural areas of Central and South America. Only molecular identification performed on formalin-fixed paraffin-embedded liver tissue samples gave an unequivocal diagnosis of this disease in a Paraguayan immigrant in Argentina.

Published
2013
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3. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases

Author

Jean-Paul Casalta, Pierre-Edouard Fournier, Jean-Pierre Arzouni, Franck Thuny, Hervé Richet, Didier Raoult, Jean-Luc Mainardi, Marie Célard, Thierry Caus, Gilbert Habib, Frederic Collart, Max Maurin, Hubert Lepidi, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Fédération de Microbiologie Clinique, Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire de microbiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chirurgie cardiaque, CHU Amiens-Picardie, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille ( APHM ) - Hôpital de la Timone [CHU - APHM] ( TIMONE ), Hôpital de la Timone [CHU - APHM] ( TIMONE ), Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] ( LAPM ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ), Université de Picardie Jules Verne ( UPJV ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, MESH: Endocarditis, MESH : Molecular Sequence Data, MESH : Pathology, Molecular, MESH : Immunohistochemistry, MESH : Prospective Studies, MESH : Aged, MESH: Molecular Diagnostic Techniques, 030204 cardiovascular system & hematology, Polymerase Chain Reaction, Serology, 0302 clinical medicine, MESH: Aged, 80 and over, MESH : Child, Neoplasms, MESH: Autoimmune Diseases, MESH: Child, Blood culture, MESH : Female, MESH: Neoplasms, 030212 general & internal medicine, Prospective Studies, Pathology, Molecular, Child, MESH : Polymerase Chain Reaction, Aged, 80 and over, Immunoassay, MESH: Aged, MESH: Middle Aged, medicine.diagnostic_test, biology, Endocarditis, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Bacterial Infections, Middle Aged, MESH : Adult, MESH : Immunoassay, Immunohistochemistry, MESH : Endocarditis, 3. Good health, MESH : Bacterial Infections, Infectious Diseases, [ SDV.BID.EVO ] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Molecular Diagnostic Techniques, MESH: Young Adult, Female, MESH: Immunoassay, Bartonella Infection, Microbiology (medical), Bartonella, Adult, Adolescent, MESH: Bacterial Infections, MESH : Male, Molecular Sequence Data, MESH : Young Adult, Q fever, Autoimmune Diseases, Tropheryma whipplei, 03 medical and health sciences, Young Adult, MESH : Autoimmune Diseases, MESH : Adolescent, medicine, Humans, MESH : Middle Aged, MESH : Aged, 80 and over, Aged, MESH: Pathology, Molecular, MESH: Adolescent, MESH: Molecular Sequence Data, MESH: Humans, business.industry, MESH : Humans, MESH: Adult, MESH: Immunohistochemistry, MESH: Polymerase Chain Reaction, medicine.disease, biology.organism_classification, Coxiella burnetii, Virology, MESH : Neoplasms, MESH: Male, MESH: Prospective Studies, business, MESH: Female, MESH : Molecular Diagnostic Techniques
Abstract

International audience; BACKGROUND. Blood culture-negative endocarditis (BCNE) may account for up to 31% of all cases of endocarditis. METHODS. We used a prospective, multimodal strategy incorporating serological, molecular, and histopathological assays to investigate specimens from 819 patients suspected of having BCNE. RESULTS. Diagnosis of endocarditis was first ruled out for 60 patients. Among 759 patients with BCNE, a causative microorganism was identified in 62.7%, and a noninfective etiology in 2.5%. Blood was the most useful specimen, providing a diagnosis for 47.7% of patients by serological analysis (mainly Q fever and Bartonella infections). Broad-range polymerase chain reaction (PCR) of blood and Bartonella-specific Western blot methods diagnosed 7 additional cases. PCR of valvular biopsies identified 109 more etiologies, mostly streptococci, Tropheryma whipplei, Bartonella species, and fungi. Primer extension enrichment reaction and autoimmunohistochemistry identified a microorganism in 5 additional patients. No virus or Chlamydia species were detected. A noninfective cause of endocarditis, particularly neoplasic or autoimmune disease, was determined by histological analysis or by searching for antinuclear antibodies in 19 (2.5%) of the patients. Our diagnostic strategy proved useful and sensitive for BCNE workup. CONCLUSIONS. We highlight the major role of zoonotic agents and the underestimated role of noninfective diseases in BCNE. We propose serological analysis for Coxiella burnetii and Bartonella species, detection of antinuclear antibodies and rheumatoid factor as first-line tests, followed by specific PCR assays for T. whipplei, Bartonella species, and fungi in blood. Broad-spectrum 16S and 18S ribosomal RNA PCR may be performed on valvular biopsies, when available.

Published
2010
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