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11 results on '"Li, Katherine"'

1. Additional file 4: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Introduction to Pay-It-Forward pamphlet (English version). This is the English version of the pamphlet used by study organizers to introduce pay-it-forward to eligible men. (PPTX 311 kb)

2. Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Author

Powell, Nick, Pantazi, Eirini, Pavlidis, Polychronis, Tsakmaki, Anastasia, Li, Katherine, Yang, Feifei, Parker, Aimee, Pin, Carmen, Cozzetto, Domenico, Minns, Danielle, Stolarczyk, Emilie, Saveljeva, Svetlana, Mohamed, Rami, Lavender, Paul, Afzali, Behdad, Digby-Bell, Jonathan, Tjir-Li, Tsui, Kaser, Arthur, Friedman, Joshua, MacDonald, Thomas T, Bewick, Gavin A, and Lord, Graham M

Subjects
Transcription, Genetic, Cell Survival, Colon, Apoptosis, Interleukin-23, Mice, Crohn Disease, Gastrointestinal Agents, inflammatory bowel disease, Animals, Humans, Intestinal Mucosa, Interleukins, Tunicamycin, Interleukin-17, Patient Acuity, Epithelial Cells, Colitis, Endoplasmic Reticulum Stress, Phenylbutyrates, digestive system diseases, Recombinant Proteins, 3. Good health, Anti-Bacterial Agents, Organoids, Disease Models, Animal, Interleukin 22, Chronic Disease, Unfolded Protein Response, Ustekinumab, ER stress
Abstract

OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22-mediated regulation of colonic epithelial cells. DESIGN: To investigate the functional role of IL22 in chronic colitis and how it regulates colonic epithelial cells, we employed a three-dimentional mini-gut epithelial organoid system, in vivo disease models and transcriptomic datasets in human IBD. RESULTS: As well as inducing transcriptional modules implicated in antimicrobial responses, IL22 also coordinated an endoplasmic reticulum (ER) stress response transcriptional programme in colonic epithelial cells. In the colon of patients with active colonic Crohn's disease (CD), there was enrichment of IL22-responsive transcriptional modules and ER stress response modules. Strikingly, in an IL22-dependent model of chronic colitis, targeting IL22 alleviated colonic epithelial ER stress and attenuated colitis. Pharmacological modulation of the ER stress response similarly impacted the severity of colitis. In patients with colonic CD, antibody blockade of IL12p40, which simultaneously blocks IL12 and IL23, the key upstream regulator of IL22 production, alleviated the colonic epithelial ER stress response. CONCLUSIONS: Our data challenge perceptions of IL22 as a predominantly beneficial cytokine in IBD and provide novel insights into the molecular mechanisms of IL22-mediated pathogenicity in chronic colitis. Targeting IL22-regulated pathways and alleviating colonic epithelial ER stress may represent promising therapeutic strategies in patients with colitis. TRIAL REGISTRATION NUMBER: NCT02749630.

3. Additional file 4: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Introduction to Pay-It-Forward pamphlet (English version). This is the English version of the pamphlet used by study organizers to introduce pay-it-forward to eligible men. (PPTX 311 kb)

4. Additional file 2: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Survey instrument (English version). This is the English version of the survey for our study. (DOCX 74 kb)

5. Additional file 3: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
education, bacterial infections and mycoses, urologic and male genital diseases, female genital diseases and pregnancy complications, 3. Good health
Abstract

Introduction to Gonorrhea and Chlamydia pamphlet (English version). This is the English version of the pamphlet used by study organizers to introduce Gonorrhea and Chlamydia to eligible men. (PPTX 779 kb)

6. Additional file 2: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Survey instrument (English version). This is the English version of the survey for our study. (DOCX 74 kb)

7. Additional file 5: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Informed consent form (English version). This is the English version of the informed consent form for our study. (DOCX 47 kb)

8. Additional file 1: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Multilingual abstracts in the five official working languages of the United Nations. (PDF 541 kb)

9. Additional file 1: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Multilingual abstracts in the five official working languages of the United Nations. (PDF 541 kb)

10. Additional file 5: of Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial

Author

Tiange Zhang, Yang, Fan, Weiming Tang, Alexander, Marcus, Forastiere, Laura, Kumar, Navin, Li, Katherine, Zou, Fei, Ligang Yang, Guodong Mi, Yehua Wang, Wenting Huang, Lee, Amy, Weizan Zhu, Vickerman, Peter, Wu, Dan, Yang, Bin, Christakis, Nicholas, and Tucker, Joseph

Subjects
3. Good health
Abstract

Informed consent form (English version). This is the English version of the informed consent form for our study. (DOCX 47 kb)

11. Quantitative evaluation of an innovation contest to enhance a sexual health campaign in China

Author

Tang, Songyuan, Yang, Bin, Zheng, Heping, Zhang, Ye, Glidden, David, Bayus, Barry L, Wei, Chongyi, Tucker, Joseph, Tso, Lai S, Tang, Weiming, and Li, Katherine

Subjects
education, 16. Peace & justice, 3. Good health
Abstract

Background Crowdsourcing method is an excellent tool for developing tailored interventions to improve sexual health. We evaluated the implementation of an innovation contest for sexual health promotion in China. Methods We organized an innovation contest over three months in 2014 for Chinese individuals

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