1. Scattered slice SHARD reconstruction for motion correction in multi-shell diffusion MRI
- Author
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A. David Edwards, Daan Christiaens, Jana Hutter, Joseph V. Hajnal, Lucilio Cordero-Grande, Jacques-Donald Tournier, Maximilian Pietsch, Maria Deprez, Anthony N. Price, Katy Vecchiato, and Emer Hughes
- Subjects
RMSE, root-mean-square error ,Computer science ,Cognitive Neuroscience ,Movement ,FOS: Physical sciences ,050105 experimental psychology ,Article ,Diffusion MRI ,lcsh:RC321-571 ,FWHM, full width half maximum ,03 medical and health sciences ,ODF, orientation distribution function ,0302 clinical medicine ,dMRI, diffusion magnetic resonance imaging ,GMM, Gaussian mixture model ,Connectome ,Image Processing, Computer-Assisted ,Humans ,0501 psychology and cognitive sciences ,Computer vision ,Angular resolution ,Neonatal imaging ,Slice-to-volume reconstruction ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,SH, spherical harmonics ,Human Connectome Project ,Orientation (computer vision) ,business.industry ,05 social sciences ,Multi-shell ,Infant, Newborn ,Spherical harmonics ,Brain ,SNR, signal-to-noise ratio ,Physics - Medical Physics ,EPI, echo planar imaging ,SHARD, spherical harmonics and radial decomposition ,Shard ,Diffusion Magnetic Resonance Imaging ,Neurology ,dHCP, developing Human Connectome Project ,SSP, slice sensitivity profile ,Motion correction ,Medical Physics (physics.med-ph) ,Artificial intelligence ,business ,030217 neurology & neurosurgery ,SVD, singular value decomposition - Abstract
Diffusion MRI offers a unique probe into neural microstructure and connectivity in the developing brain. However, analysis of neonatal brain imaging data is complicated by inevitable subject motion, leading to a series of scattered slices that need to be aligned within and across diffusion-weighted contrasts. Here, we develop a reconstruction method for scattered slice multi-shell high angular resolution diffusion imaging (HARDI) data, jointly estimating an uncorrupted data representation and motion parameters at the slice or multiband excitation level. The reconstruction relies on data-driven representation of multi-shell HARDI data using a bespoke spherical harmonics and radial decomposition (SHARD), which avoids imposing model assumptions, thus facilitating to compare various microstructure imaging methods in the reconstructed output. Furthermore, the proposed framework integrates slice-level outlier rejection, distortion correction, and slice profile correction. We evaluate the method in the neonatal cohort of the developing Human Connectome Project (650 scans). Validation experiments demonstrate accurate slice-level motion correction across the age range and across the range of motion in the population. Results in the neonatal data show successful reconstruction even in severely motion-corrupted subjects. In addition, we illustrate how local tissue modelling can extract advanced microstructure features such as orientation distribution functions from the motion-corrected reconstructions., revision. 15 pages, 10 figures, 2 tables
- Published
- 2021