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Sampling methods are important factors that can potentially limit the accuracy of predictions of spatial distribution patterns. A 10 ha tobacco-planted field was selected to compared the accuracy in predicting the spatial distribution of soil properties by using ordinary kriging and cross validation methods between grid sampling and simple random sampling scheme (SRS). To achieve this objective, we collected soil samples from the topsoil (0-20 cm) in March 2012. Sample numbers of grid sampling and SRS were both 115 points each. Accuracies of spatial interpolation using the two sampling schemes were then evaluated based on validation samples (36 points) and deviations of the estimates. The results suggested that soil pH and nitrate-N (NO 3 -N) had low variation, whereas all other soil properties exhibited medium variation. Soil pH, organic matter (OM), total nitrogen (TN), cation exchange capacity (CEC), total phosphorus (TP) and available phosphorus (AP) matched the spherical model, whereas the remaining variables fit an exponential model with both sampling methods. The interpolation error of soil pH, TP, and AP was the lowest in SRS. The errors of interpolation for OM, CEC, TN, available potassium (AK) and total potassium (TK) were the lowest for grid sampling. The interpolation precisions of the soil NO 3 -N showed no significant differences between the two sampling schemes. Considering our data on interpolation precision and the importance of minerals for cultivation of flue-cured tobacco, the grid-sampling scheme should be used in tobacco-planted fields to determine the spatial distribution of soil properties. The grid-sampling method can be applied in a practical and cost-effective manner to facilitate soil sampling in tobacco-planted field.