1. Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
- Author
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Reyes, LF, Murthy, S, Garcia-Gallo, E, Irvine, M, Merson, L, Martin-Loeches, I, Rello, J, Taccone, FS, Fowler, RA, Docherty, AB, Kartsonaki, C, Aragao, I, Barrett, PW, Beane, A, Burrell, A, Cheng, MP, Christian, MD, Cidade, JP, Citarella, BW, Donnelly, CA, Fernandes, SM, French, C, Haniffa, R, Harrison, EM, Ho, AYW, Joseph, M, Khan, I, Kho, ME, Kildal, AB, Kutsogiannis, D, Lamontagne, F, Lee, TC, Bassi, GL, Lopez Revilla, JW, Marquis, C, Millar, J, Neto, R, Nichol, A, Parke, R, Pereira, R, Poli, S, Povoa, P, Ramanathan, K, Rewa, O, Riera, J, Shrapnel, S, Silva, MJ, Udy, A, Uyeki, T, Webb, SA, Wils, E-J, Rojek, A, Olliaro, PL, Institut Català de la Salut, [Reyes LF] Universidad de La Sabana, Chía, Colombia. Nuffield Dept of Medicine, University of Oxford, Oxford, UK. [Murthy S] British Columbia Children’s Hospital, Vancouver, BC, Canada. [Garcia-Gallo E] Universidad de La Sabana, Chía, Colombia. [Irvine M] British Columbia Centre for Disease Control, Vancouver, BC, Canada. [Merson L] Nuffield Dept of Medicine, University of Oxford, Oxford, UK. [Martin-Loeches I] Intensive Care Medicine, St James’s Hospital, Dublin, Ireland. [Rello J] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, and Medical Research Council (MRC)
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Pulmonary and Respiratory Medicine ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,COVID-19 (Malaltia) - Factors de risc ,Avaluació de resultats (Assistència sanitària) ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,Original Research Article ,030212 general & internal medicine ,3. Good health - Abstract
Respiratory infections and tuberculosis Infecciones respiratorias y tuberculosis Infeccions respiratòries i tuberculosi Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p
- Published
- 2022