1. Incomplete Administration of Intravenous Vancomycin Prophylaxis is Common and Associated With Increased Infectious Complications After Primary Total Hip and Knee Arthroplasty
- Author
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Ran Schwarzkopf, Joseph A. Bosco, James D. Slover, David Yeroushalmi, Charles C. Lin, William Macaulay, Matthew S. Galetta, Claudette M. Lajam, Oren I. Feder, and Moretza Meftah
- Subjects
Methicillin-Resistant Staphylococcus aureus ,musculoskeletal diseases ,medicine.medical_specialty ,Prosthesis-Related Infections ,medicine.drug_class ,Arthroplasty, Replacement, Hip ,medicine.medical_treatment ,Antibiotics ,Total hip replacement ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Vancomycin ,medicine ,Humans ,Orthopedics and Sports Medicine ,Antibiotic prophylaxis ,Arthroplasty, Replacement, Knee ,Retrospective Studies ,030222 orthopedics ,Tourniquet ,business.industry ,Perioperative ,Antibiotic Prophylaxis ,Arthroplasty ,Anti-Bacterial Agents ,Surgery ,Staphylococcus aureus ,business ,medicine.drug - Abstract
Vancomycin is often used as antimicrobial prophylaxis in patients undergoing total hip or knee arthroplasty. Vancomycin requires longer infusion times to avoid associated side effects. We hypothesized that vancomycin infusion is often started too late and that delayed infusion may predispose patients to increased rates of surgical site infections and prosthetic joint infections.We reviewed clinical data for all primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients at our institution between 2013 and 2020 who received intravenous vancomycin as primary perioperative gram-positive antibiotic prophylaxis. We calculated duration of infusion before incision or tourniquet inflation, with a cutoff of 30 minutes defining adequate administration. Patients were divided into two groups: 1) appropriate administration and 2) incomplete administration. Surgical factors and quality outcomes were compared between groups.We reviewed 1047 primary THA and TKA patients (524 THAs and 523 TKAs). The indication for intravenous vancomycin usage was allergy (61%), methicillin-resistant staphylococcus aureus colonization (17%), both allergy and colonization (14%), and other (8%). 50.4% of patients began infusion30 minutes preoperatively (group A), and 49.6% began infusion30 minutes preoperatively (group B). Group B had significantly higher rates of readmissions for infectious causes (3.6 vs 1.3%, P = .017). This included a statistically significant increase in confirmed prosthetic joint infections (2.2% vs 0.6%, P = .023). Regression analysis confirmed30 minutes of vancomycin infusion as an independent risk factor for PJI when controlling for comorbidities (OR 5.22, P = .012).Late infusion of vancomycin is common and associated with increased rates of infectious causes for readmission and PJI. Preoperative protocols should be created to ensure appropriate vancomycin administration when indicated.
- Published
- 2021
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