1. Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations
- Author
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Tamara Intermesoli, Roberta Cavagna, Elena Oldani, Anna Salvi, Greta Ubiali, Barbara Peruta, Renato Bassan, Marie Lorena Guinea Montalvo, Alessandro Rambaldi, Orietta Spinelli, Ursula Giussani, Chiara Pavoni, Manuela Tosi, S Salmoiraghi, Salmoiraghi, S, Cavagna, R, Montalvo, M, Ubiali, G, Tosi, M, Peruta, B, Intermesoli, T, Oldani, E, Salvi, A, Pavoni, C, Giussani, U, Bassan, R, Rambaldi, A, and Spinelli, O
- Subjects
immunoglobulin rearrangements ,biology ,Adult patients ,lcsh:QH426-470 ,Immunoglobulin rearrangement ,T-cell receptor ,Clone (cell biology) ,acute lymphoblastic leukemia ,Minimal residual disease ,Molecular biology ,03 medical and health sciences ,Transformation (genetics) ,lcsh:Genetics ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Genetics ,biology.protein ,Adult Acute Lymphoblastic Leukemia ,TP53 ,Antibody ,Immunoglobulin Gene Rearrangement ,Genetics (clinical) ,030215 immunology - Abstract
Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.
- Published
- 2020