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Start Over Author "Granato, I." Topic 030220 oncology & carcinogenesis
2 results on '"Granato, I."'

1. No evidence of increased cerebrovascular involvement in adult neurologically-asymptomatic β-Thalassaemia. A multicentre multimodal magnetic resonance study

Author

Gianluca Femina, Antonietta Canna, Sara Ponticorvo, Renzo Manara, Violetta Caserta, Maddalena Casale, Paolo Gritti, Elisa De Michele, Silverio Perrotta, Andrea G. Russo, Teresa Ferrantino, Camilla Russo, Martina Caiazza, Mario Cirillo, Giovanni Amendola, Antonella Centanni, Noemi Ippolito, Fabrizio Esposito, Angela Ciancio, Rosanna Di Concilio, Andrea Elefante, Ilaria Granato, Mario Ermani, Tiziana Oliveto, Pasquale Alessandro Carafa, Immacolata Tartaglione, Tartaglione, Immacolata, Russo, Camilla, Elefante, Andrea, Caiazza, Martina, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Amendola, Giovanni, Gritti, Paolo, Carafa, Pasquale A, Ferrantino, Teresa, Centanni, Antonella, Ippolito, Noemi, Caserta, Violetta, Oliveto, Tiziana, Granato, Ilaria, Femina, Gianluca, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea G, Canna, Antonietta, Ermani, Mario, Cirillo, Mario, Perrotta, Silverio, Manara, Renzo, Tartaglione, I., Russo, C., Elefante, A., Caiazza, M., Casale, M., Di Concilio, R., Ciancio, A., De Michele, E., Amendola, G., Gritti, P., Carafa, P. A., Ferrantino, T., Centanni, A., Ippolito, N., Caserta, V., Oliveto, T., Granato, I., Femina, G., Esposito, F., Ponticorvo, S., Russo, A. G., Canna, A., Ermani, M., Cirillo, M., Perrotta, S., and Manara, R.

Subjects
Adult, medicine.medical_specialty, brain MRI, Adolescent, transfusion medicine, Venography, thalassaemia, Asymptomatic, Magnetic resonance angiography, Brain Ischemia, White matter, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Leukoencephalopathies, medicine, Humans, thrombosi, Prospective Studies, vascular malformations, thrombosis, Aged, medicine.diagnostic_test, business.industry, beta-Thalassemia, Brain, Intracranial Aneurysm, Magnetic resonance imaging, Intracranial Artery, Hematology, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Thrombosis, Hyperintensity, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Radiology, Nervous System Diseases, medicine.symptom, business, Magnetic Resonance Angiography, 030215 immunology
Abstract

Multi-factorial causes jeopardize brain integrity in β-thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β-thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β-thalassaemia patients (mean-age 35·2±10·7years; 52/75 transfusion-dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected. White matter ischaemic-like abnormalities, intracranial artery stenoses, aneurysms and sinus venous thrombosis were compared between patients and 56 healthy controls (mean-age 33·9±10·8years). No patient or control showed silent territorial or lacunar strokes, intracranial artery stenoses or signs of sinus thrombosis. White matter lesions were found both in patients (35/75, 46·7%) and controls (28/56, 50·0%), without differences in terms of number (4·0±10·6 vs. 4·6±9·1, P=0·63), size and Fazekas' Score. Intracranial aneurysms did not differ between patients and controls for incidence rate (7/75, 9·3% vs. 5/56, 8·9%), size and site. Vascular and parenchymal abnormality rate did not differ according to treatments or clinical phenotype. According to this study, asymptomatic β-thalassaemia patients treated according to current guidelines do not seem to carry an increased risk of brain and intracranial vascular changes, thus weakening recommendations for regular brain MRI monitoring.

Published
2019

2. Brain functional impairment in beta-thalassaemia: the cognitive profile in Italian neurologically asymptomatic adult patients in comparison to the reported literature

Author

Immacolata Tartaglione, Paolo Gritti, Silverio Perrotta, Teresa Ferrantino, Violetta Caserta, Renzo Manara, Fabrizio Esposito, Caterina Maietta, Mario Cirillo, Sara Ponticorvo, Rosanna Di Concilio, Pasquale Alessandro Carafa, Elisa De Michele, Antonella Centanni, Gianluca Femina, Angela Ciancio, Martina Caiazza, Noemi Ippolito, Antonietta Canna, Andrea G. Russo, Mario Ermani, Andrea Elefante, Ilaria Granato, Camilla Russo, Maddalena Casale, Tiziana Oliveto, Tartaglione, I., Manara, R., Caiazza, M., Carafa, P. A., Caserta, V., Ferrantino, T., Granato, I., Ippolito, N., Maietta, C., Oliveto, T., Casale, M., Di Concilio, R., Ciancio, A., De Michele, E., Russo, Cristiana, Elefante, A., Ponticorvo, S., Russo, A. G., Femina, G., Canna, A., Ermani, M., Cirillo, M., Esposito, F., Centanni, A., Gritti, P., Perrotta, S., and Russo, C.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, blood transfusion, Gastroenterology, Asymptomatic, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Internal medicine, Brief Psychiatric Rating Scale, Wechsler Adult Intelligence Scale, medicine, Humans, Cognitive Dysfunction, Prospective Studies, Prospective cohort study, beta-thalassaemia, brain magnetic resonance imaging, intelligence quotient, Depression (differential diagnoses), Aged, Intelligence quotient, business.industry, beta-Thalassemia, Brain, Hematology, Middle Aged, Mental Status and Dementia Tests, Magnetic Resonance Imaging, Italy, 030220 oncology & carcinogenesis, Anxiety, Female, Symptom Assessment, medicine.symptom, business, 030215 immunology
Abstract

Cognitive involvement in beta-thalassaemia is strikingly controversial and poorly studied in adulthood. This multicentre prospective study investigated 74 adult neurologically-asymptomatic beta-thalassaemia patients (mean-age 34 center dot 5 +/- 10 center dot 3 years; 53 transfusion-dependent [TDT], 21 non-transfusion dependent [NTDT]) and 45 healthy volunteers (mean-age 33 center dot 9 +/- 10 center dot 7 years). Participants underwent testing with Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV), Brief Psychiatric Rating Scale (BPRS) and multiparametric brain 3T-magnetic resonance imaging (MRI) for parenchymal, vascular and iron content evaluation. Patients had lower Full-Scale Intelligence Quotient (FSIQ) than controls (75 center dot 5 +/- 17 center dot 9 vs. 97 center dot 4 +/- 18 center dot 1, P < 0 center dot 0001) even after correction for education level. Compared to TDT, NTDT showed a trend of higher FSIQ (P = 0 center dot 08) but a similar cognitive profile at WAIS-subtests. FSIQ correlated with total and indirect bilirubin (P P = 0 center dot 002, respectively); no correlation was found with splenectomy, intracranial MRI/magnetic resonance-angiography findings, brain tissue iron content or other disease-related clinical/laboratory/treatment data. FSIQ did not correlate with BPRS scores, although the latter were higher among patients (28 center dot 74 +/- 3 center dot 1 vs. 27 center dot 29 +/- 4 center dot 8, P = 0 center dot 01) mainly because of increased depression and anxiety levels. Occupation rate was higher among controls (84 center dot 4% vs. 64 center dot 9%, P = 0 center dot 004) and correlated with higher FSIQ (P = 0 center dot 001) and education level (P = 0 center dot 001). In conclusion, Italian adult beta-thalassaemia patients seem to present a characteristic cognitive profile impairment and an increased rate of psychological disorders with possible profound long-term socio-economic consequences.

Published
2019

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