1. Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside
- Author
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Kenia Pedrosa Nunes, Amanda Almeida de Oliveira, and Destiny Davis
- Subjects
0301 basic medicine ,Metabolic Syndrome ,business.industry ,animal diseases ,Endocrinology, Diabetes and Metabolism ,Pattern recognition receptor ,General Medicine ,Bioinformatics ,medicine.disease ,Bench to bedside ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Diabetes mellitus ,Receptors, Pattern Recognition ,Internal Medicine ,Medicine ,Animals ,Humans ,Metabolic syndrome ,Receptor ,business ,Signal Transduction - Abstract
Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approach to avoid the development of further complications in human subjects. In this work, we discuss the understanding regarding the roles of PRRs in the pathways of MetS to further describe potential advancements made to target these receptors within this pathology.
- Published
- 2018