1. Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study
- Author
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Alejandra Jimena García-Velázquez, Karina Anastacia Solís-Labastida, Ana Elena Gil-Hernández, Arturo Fajardo-Gutiérrez, Angélica Rangel-López, Laura Eugenia Espinoza-Hernández, Nora Nancy Núñez-Villegas, Elva Jiménez-Hernández, David Aldebarán Duarte-Rodríguez, Minerva Mata-Rocha, Ana Itamar González-Ávila, Laura Elizabeth Merino-Pasaye, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré, Elisa Dorantes-Acosta, Omar Alejandro Sepúlveda-Robles, Martha Margarita Velázquez-Aviña, Janet Flores-Lujano, María Luisa Pérez-Saldivar, Rosa Martha Espinosa-Elizondo, Raquel Amador-Sánchez, Jessica Denisse Santillán-Juárez, Haydeé Rosas-Vargas, Beatriz Cortés-Herrera, Jorge Alfonso Martín-Trejo, Silvia Jiménez-Morales, Aurora Medina-Sanson, José Refugio Torres-Nava, Vilma Carolina Bekker-Méndez, José Gabriel Peñaloza-González, and Luz Victoria Flores-Villegas
- Subjects
Male ,0301 basic medicine ,Pediatric Obesity ,Cancer Research ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Lymphoblastic Leukemia ,Overweight ,lcsh:RC254-282 ,Disease-Free Survival ,World health ,Body Mass Index ,Early mortality ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Surgical oncology ,Genetics ,medicine ,Humans ,Obesity ,Child ,Children ,Mexico ,Leukemia ,business.industry ,Incidence ,Mortality rate ,Infant ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,030104 developmental biology ,Oncology ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business ,Follow-Up Studies ,Research Article ,Cohort study - Abstract
Background Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood overweight and obesity are reaching epidemic proportions. They have been associated with poor outcomes in children with ALL. The aim of present study was to identify if overweight and obesity are predictors of early mortality and relapse in Mexican children with ALL. Methods A multicenter cohort study was conducted. ALL children younger than 15 years old were included and followed-up during the first 24 months after diagnosis. Overweight and obesity were classified according World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) criteria. Early mortality and early relapses were the main outcomes. Results A total of 1070 children were analyzed. Overweight/obesity at diagnosis were predictors of early mortality (WHO: HR = 1.4, 95%CI:1.0–2.0; CDC: HR = 1.6, 95%CI:1.1–2.3). However, no associations between overweight (WHO: HR = 1.5, 95%CI:0.9–2.5; CDC: HR = 1.0; 95% CI:0.6–1.6) and obesity (WHO: HR = 1.5, 95%CI:0.7–3.2; CDC: HR = 1.4; 95%CI:0.9–2.3) with early relapse were observed. Conclusions Overweight and obese patients embody a subgroup with high risk of dying during leukemia treatment. Electronic supplementary material The online version of this article (10.1186/s12885-019-5878-8) contains supplementary material, which is available to authorized users.
- Published
- 2019