1. Post‐ictal accelerometer silence as a marker of post‐ictal immobility
- Author
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Elisa Bruno, Sebastian Böttcher, Andreas Schulze-Bonhage, Simon Lees, Mark P. Richardson, Andrea Biondi, Nikolay V. Manyakov, and Nino Epitashvili
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Audiology ,Electroencephalography ,Unexpected death ,Cohort Studies ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Seizures ,Accelerometry ,medicine ,Humans ,Ictal ,Sudden Unexpected Death in Epilepsy ,Confusion ,Exercise ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Silence ,030104 developmental biology ,Convulsive Seizures ,Increased risk ,nervous system ,Neurology ,Duration (music) ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVE Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complications and with sudden unexpected death in epilepsy (SUDEP). We aimed to assess whether wearable accelerometers (ACCs) could be used as a digital marker of PI. METHOD Devices with embedded ACCs were worn by patients admitted to an epilepsy monitoring unit. Participants presenting with convulsive seizures were included in the study. PI presence and duration were assessed by experts reviewing video recordings. An algorithm for the automatic detection of post-ictal ACC silence and its duration was developed and the linear pairwise relationship between the automatically detected duration of post-ictal ACC silence and the duration of the expert-labeled PI was analyzed. RESULTS Twenty-two convulsive seizures were recorded from 18 study participants. Twenty were followed by PI and two by agitation. The automated estimation of post-ictal ACC silence identified all the 20 expert-labeled PI. The regression showed that the duration of the post-ictal ACC silence was correlated with the duration of PI (Pearson r = .92; P
- Published
- 2020