1. Identifying New Antimigraine Targets: Lessons from Molecular Biology
- Author
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Lars Edvinsson and Kristian Agmund Haanes
- Subjects
0301 basic medicine ,Calcitonin Gene-Related Peptide ,Migraine Disorders ,Calcitonin gene-related peptide ,Toxicology ,calcitonin gene-related peptide ,node of Ranvier, Aδ fibers ,03 medical and health sciences ,0302 clinical medicine ,Primary headache ,medicine ,Humans ,Molecular Biology ,Sensitization ,Neurons ,trigeminovascular system, G-protein coupled receptors ,Pharmacology ,business.industry ,C fibers ,Trigeminovascular system ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Migraine ,business ,Neuroscience ,030217 neurology & neurosurgery ,Receptors, Calcitonin Gene-Related Peptide - Abstract
Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.
- Published
- 2021