1. Role of stress in the development of rheumatoid arthritis: a case–control study
- Author
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Emilie Shipley, Clémence Pichon, Lucile Capuron, Jennifer Foret, L. Lequen, Fédération Hospitalo-Universitaire Acronim, Vincent Germain, Marc Scherlinger, Thierry Schaeverbeke, Thomas Barnetche, Alexandre Balageas, Stéphanie Dublanc, CHU Bordeaux [Bordeaux], Centre hospitalier de Pau, Centre Hospitalier de Dax, Centre Hospitalier Libourne, Nutrition et Neurobiologie intégrée (NutriNeuro), and Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
- Subjects
Adult ,Male ,rheumatoid arthritis ,Coping (psychology) ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Arthritis, Rheumatoid ,stress ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Rheumatology ,Surveys and Questionnaires ,Internal medicine ,Adaptation, Psychological ,medicine ,Humans ,Pharmacology (medical) ,030203 arthritis & rheumatology ,business.industry ,Incidence ,Stressor ,Life events ,Case-control study ,Middle Aged ,social support ,anxiety ,medicine.disease ,life events ,coping ,Holmes and Rahe stress scale ,Case-Control Studies ,Rheumatoid arthritis ,Anxiety ,Female ,France ,medicine.symptom ,business ,Stress, Psychological ,030217 neurology & neurosurgery - Abstract
Objectives The primary objective of this study was to assess the stressful life events preceding the onset of symptoms in RA. The secondary objectives were to assess how early RA patients perceive stress and cope with stressors. Methods A case–control study was performed, comparing patients recently diagnosed with RA to age- and gender-matched control subjects recently hospitalized for an unplanned surgical procedure not known to be influenced by stress. The Social Readjustment Rating Scale assessed the cumulative stress induced by stressful life events in the year preceding the onset of symptoms. Coping strategies, stress and anxiety symptoms were evaluated using validated psychological scales. Results Seventy-six subjects were included in each group. The mean Social Readjustment Rating Scale score was twice as high in cases compared with controls [respectively, 167.0 (172.5) vs 83.3 (124.4), P Conclusion Patients with early RA reported more life events in the year preceding the onset of symptoms than controls. Gender specificities were found with a significant association between cumulative stress and RA only in women.
- Published
- 2021
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