1. The genetic and epigenetic landscapes of hepatoblastomas
- Author
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Isabela Werneck da Cunha, Cecília Maria Lima da Costa, Talita Ferreira Marques Aguiar, Ana Cristina Victorino Krepischi, Carla Rosenberg, and Thaise Nayane Carneiro
- Subjects
0301 basic medicine ,Genetics ,Hepatoblastoma ,Pediatric liver tumor ,General Medicine ,Biology ,MUTAÇÃO ,medicine.disease_cause ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Embryonal cancer ,03 medical and health sciences ,Liver cell differentiation ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Epigenetics ,Carcinogenesis ,Genetic predisposition, Mutation, Epigenetics - Abstract
Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However, mainly because of its rarity, molecular data on HB tumorigenesis remain scarce. This article reviews the current knowledge regarding genetic and epigenetic alterations reported in HB cases, with emphasis on the recent findings of next-generation sequencing studies.
- Published
- 2017