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1. Effect of Change in Newborn’s Position during Mechanical Ventilation on Oxygenation

Author: Razek Mohammed Hefny Elshiekh, Atef Ibrahim Nosair, and Enas Mohammed Mahmoud Radwan Elshazly
Subjects: Mechanical ventilation, Neonatal intensive care unit, Supine position, business.industry, medicine.medical_treatment, Hemodynamics, Oxygenation, Respiratory physiology, 03 medical and health sciences, Prone position, 0302 clinical medicine, 030228 respiratory system, Anesthesia, medicine, Breathing, 030212 general & internal medicine, business
Abstract: Background: Acute respiratory failure remains an important cause of morbidity and mortality in children. In the last few years great attention was paid to the effect of changes in infant’s position other than the supine position during mechanicall ventilation. Objective: To evaluate the effect of position change on oxygenation in newborn infants during mechanical ventilation in neonatal intensive care unit (NICU). Methods: This study was across- section study, which was done on 74 obese children aged 6-18 years. This study was done at Pediatrics Department, Zagazig University Hospitals, during the period from 2017 to 2018. The cases were divided into two groups, group A included newborn infants using ventilators in supine position (supine group) and group B included newborn infants in supine position alternating with prone position (alternate group). All children were subjected to history talking and clinical examination. Anthropometric measurements were measured. In addition, carotid intima-media thickness quantification was estimated. Results: There were statistically significant decrease in VT (ml) at (8 hr and 16 hr) among alternate group than supine group. In addition, OI and PaO2, at 8 and 16 h in alternate position groups were higher than those in supine position group were. There were statistically significant decrease in PEEP (cm H2O) at 8 hour among supine group than alternate group. There was no statistically significant difference between supine group and alternate group regarding PEEP (cm H2O) at 16 hour. This study showed that, There were statistically significant decrease in PaO2 (mm Hg) at (8 hr and 1 hr drawl) among supine group than alternate group. There was no statistically significant difference between supine group and alternate group regarding PaO2 (mm Hg) at 16 hr. Conclusion: Oxygenation and respiratory mechanics were significantly improved in prone position group than those in supine position group. The physiological basis of prone positioning seems to act beneficially improving hemodynamics, gas exchange and respiratory mechanics.
Published: 2020

2. Burden of lower respiratory infections in the Eastern Mediterranean Region between 1990 and 2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Moradi-Lakeh, Maziar, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Afshin, Ashkan, Kassebaum, Nicholas J, Collison, Michael, Daoud, Farah, Chew, Adrienne, Krohn, Kristopher J, Colombara, Danny, Ehrenkranz, Rebecca, Foreman, Kyle J, Frostad, Joseph, Godwin, William W, Kutz, Michael, Rao, Puja C, Reiner, Robert, Troeger, Christopher, Wang, Haidong, Abajobir, Amanuel Alemu, Abbas, Kaja M, Abera, Semaw Ferede, Abu-Raddad, Laith J, Adane, Kelemework, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Beshir, Muktar, Al-Eyadhy, Ayman, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Alizadeh-Navaei, Reza, Al-Maskari, Fatma, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mehari, Arthur, Euripide Frinel G, Bacha, Umar, Barac, Aleksandra, Bazargan-Hejazi, Shahrzad, Drew, Charles R, Geffen, David, Bedi, Neeraj, Bhutta, Zulfiqar A, Michael, Brauer, Butt, Zahid A, Castaneda-Orjuela, Carlos A, Danawi, Hadi, Djalalinia, Shirin, Endries, Aman Yesuf, Eshrati, Babak, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Garcia-Basteiro, Alberto L, Gebrehiwot, Kiros Tedla, Gebrehiwot, Tsegaye Tewelde, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hassanvand, Mohammad Sadegh, Hedayati, Mohammad T, Horita, Nobuyuki, Husseini, Abdullatif, Spencer, Lewis James, Javanbakht, Mehdi, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khoja, Abdullah Tawfih Abdullah, Khubchandani, Jagdish, Kim, Yun Jin, Kissoon, Niranjan, Larson, Heidi J, Latif, Asma Abdul, Leshargie, Cheru Tesema, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Farid, Habibolah Masoudi, Mehari, Alem, Memish, Ziad A, Mengistu, Desalegn Tadese, Mensah, George A, Mezgebe, Haftay Berhane, Nakamura, Sachiko, Oren, Eyal, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Vafa, Rahimi-Movaghar, Rai, Rajesh Kumar, Rawaf, David Laith, Rawaf, Salman, Refaat, Amany H, Rezaei, Satar, Rezai, Mohammad Sadegh, Roba, Hirbo Shore, Roshandel, Gholamreza, Safdarian, Mahdi, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shigematsu, Mika, Singh, Jasvinder A, Sufiyan, Muawiyyah Babale, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Topor-Madry, Roman, Uthman, Olalekan A, Vollset, Stein Emil, Wakayo, Tolassa, Werdecker, Andrea, Wijeratne, Tissa, Yaghoubi, Mohsen, Yimam, Hassen Hamid, Yonemoto, Naohiro, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Naghavi, Mohsen, Hay, Simon I, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, and Hay, S
Subjects: Adult, Male, medicine.medical_specialty, Health (social science), Adolescent, 030231 tropical medicine, Disease, Eastern, Global Health, Eastern Mediterranean Region, Global Burden of Disease, 03 medical and health sciences, Middle East, Young Adult, 0302 clinical medicine, Risk Factors, Environmental health, medicine, Global health, Humans, 030212 general & internal medicine, Mortality, Child, Respiratory Tract Infections, Aged, DALY, Respiratory tract infections, business.industry, Mediterranean Region, Public health, Incidence (epidemiology), Incidence, Public Health, Environmental and Occupational Health, Age Factors, Infant, Middle Aged, medicine.disease, Quality-adjusted life year, Lower respiratory infection, Malnutrition, 1117 Public Health And Health Services, Child, Preschool, Life expectancy, Female, Original Article, Quality-Adjusted Life Years, Public Health, business
Abstract: We used data from the Global Burden of Disease 2015 study (GBD) to calculate the burden of lower respiratory infections (LRIs) in the 22 countries of the Eastern Mediterranean Region (EMR) from 1990 to 2015. We conducted a systematic analysis of mortality and morbidity data for LRI and its specific etiologic factors, including pneumococcus, Haemophilus influenzae type b, Respiratory syncytial virus, and influenza virus. We used modeling methods to estimate incidence, deaths, and disability-adjusted life-years (DALYs). We calculated burden attributable to known risk factors for LRI. In 2015, LRIs were the fourth-leading cause of DALYs, causing 11,098,243 (95% UI 9,857,095-12,396,566) DALYs and 191,114 (95% UI 170,934-210,705) deaths. The LRI DALY rates were higher than global estimates in 2015. The highest and lowest age-standardized rates of DALYs were observed in Somalia and Lebanon, respectively. Undernutrition in childhood and ambient particulate matter air pollution in the elderly were the main risk factors. Our findings call for public health strategies to reduce the level of risk factors in each age group, especially vulnerable child and elderly populations. Horizon Pharmaceuticals; American College of Rheumatology's (ACR) Annual Meeting Planning Committee (AMPC); Veterans Affairs Rheumatology Field Advisory Committee; Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee Dr. Carl Abelardo T. Antonio reports Grants and personal fees from Johnson and Johnson (Philippines), Inc. outside the submitted work. Dr. Jasvinder Singh serves as the principal investigator for an investigator-initiated study funded by Horizon Pharmaceuticals through a grant to DINORA, Inc., a 501 (c)(3) entity. Dr. Singh is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology's (ACR) Annual Meeting Planning Committee (AMPC); Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. Other authors have no conflict of interest.
Published: 2017
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3. Burden of vision loss in the Eastern Mediterranean region, 1990–2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Safi, Sare, Ahmadieh, Hamid, Katibeh, Marzieh, Yaseri, Mehdi, Ramezani, Alireza, Shahraz, Saeid, Moradi-Lakeh, Maziar, Khalil, Ibrahim, El Bcheraoui, Charbel, Collison, Michael, Chew, Adrienne, Daoud, Farah, Krohn, Kristopher J, Rankin, Zane, Afshin, Ashkan, Kassebaum, Nicholas J, Olsen, Helen E, Stanaway, Jeffrey D, Wang, Haidong, Wilson, Katie, Yitayih, Gebre, Al-Eyadhy, Ayman, Alam, Khurshid, Alasfoor, Deena, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Anber, Nahla, Mansoura, Anber Phd University Mansoura, Ansari, Hossein, Anwari, Palwasha, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mehari, Bacha, Umar, Barac, Aleksandra, Bedi, Neeraj, Butt, Zahid A, Chitheer, Abdulaal A, Djalalinia, Shirin, Phuc, Huyen Do, Eshrati, Babak, Farvid, Maryam S, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Hamadeh, Randah Ribhi, Hamidi, Samer, Higazi, Tarig B, Hsairi, Mohamed, Jimenez-Corona, Aida, John, Denny, Jonas, Jost B, Kasaeian, Amir, Saleh, Yousef, Khan, Ejaz Ahmad, Larson, Heidi J, Latif, Asma Abdul, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, McAlinden, Colm, Memish, Ziad A, Miller, Ted R, Mohammadi, Seyed-Farzad, Nangia, Vinay, Nguyen, Cuong Tat, Nguyen, Quyen Le, Ogbo, Felix Akpojene, Pourmalek, Farshad, Qorbani, Mostafa, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Roshandel, Gholamreza, Safdarian, Mahdi, Safiri, Saeid, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Skiadaresi, Eirini, Sobaih, Badr HA, Abdulkader, Rizwan Suliankatchi, Taylor, Hugh R, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Topor-Madry, Roman, Xuan, Bach, Tsilimbaris, Miltiadis, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Wakayo, Tolassa, Yonemoto, Naohiro, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, and Reg, GBD 2015 Eastern Mediterranean
Subjects: Burden of disease, impairment, Pediatrics, medicine.medical_specialty, Health (social science), Injury control, Vision, Population, Poison control, Eastern Mediterranean region, Eye care, Vision impairment, Blindness, Global Health, 03 medical and health sciences, Middle East, 0302 clinical medicine, Unit increase, Global health, Prevalence, Medicine, Humans, 030212 general & internal medicine, education, education.field_of_study, Vision disorder, business.industry, Mediterranean Region, Public Health, Environmental and Occupational Health, Global burden of disease, Eastern mediterranean, 1117 Public Health And Health Services, Socioeconomic Factors, 030221 ophthalmology & optometry, Original Article, Public Health, business, Demography
Abstract: Objectives To report the estimated trend in prevalence and years lived with disability (YLDs) due to vision loss (VL) in the Eastern Mediterranean region (EMR) from 1990 to 2015. Methods The estimated trends in age-standardized prevalence and the YLDs rate due to VL in 22 EMR countries were extracted from the Global Burden of Disease (GBD) 2015 study. The association of Socio-demographic Index (SDI) with changes in prevalence and YLDs of VL was evaluated using a multilevel mixed model. Results The age-standardized prevalence of VL in the EMR was 18.2% in 1990 and 15.5% in 2015. The total age-standardized YLDs rate attributed to all-cause VL in EMR was 536.9 per 100,000 population in 1990 and 482.3 per 100,000 population in 2015. For each 0.1 unit increase in SDI, the age-standardized prevalence and YLDs rate of VL showed a reduction of 1.5% (p
Published: 2017

4. Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

Author: Mai Yehia ElAttar, Faten Mohammed Fawzy, Abdel Razek Mohammed El Sheikh, Doaa Mohammed Youssef, Hanan S. Sherbiny, Tamer M. Adham, and Laila M. Sherief
Subjects: Creatinine, medicine.medical_specialty, medicine.drug_class, business.industry, Urinary system, Antibiotics, General Medicine, Urinary calcium, Surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Nephrology, 030225 pediatrics, Internal medicine, Renal ultrasonography, medicine, Ceftriaxone, 030212 general & internal medicine, business, Prospective cohort study, medicine.drug, Paediatric population
Abstract: Aim Ceftriaxone is a commonly used antibiotic among the paediatric population. Various reports have associated high doses of Ceftriaxone with the development of nephrolithiasis; our aim was to test this association with a 5 day course of treatment. Methods Our study group consisted of 120 patients divided into two groups. The first group included 60 patients who underwent treatment with Ceftriaxone therapy that was started empirically and continued for 5 days at the dose of 80 mg/kg per day. The second group (60 patients) who received treatment with other antibiotics (other than Ceftriaxone), as recommended by hospital protocols. Patients with urinary tract infections (UTI) were excluded as UTI may be a predisposing cause for nephrolithiasis. Baseline and follow up after 5 days were done with; abdominal ultrasound, serum urea, creatinine, serum calcium, 24 h urinary calcium and urinary calcium/ creatinine ratio. Extended metabolic tests were done for cases that developed nephrolithiasis. Results Five cases out of the 60 patients treated with Ceftriaxone developed calculi; that were small and were eliminated spontaneously in four cases at mean duration of 3 weeks. In these cases renal ultrasonography examinations were normal prior to treatment; and none of them had metabolic disturbances or risk factors leading to stone formation. By multiple regression analysis, only age was related to nephrolithiasis formation being higher in the group that has developed stones. Conclusion Only patients who underwent Ceftriaxone therapy have developed renal stones, even with a short course of therapy (5 days), and in the absence of a known predisposing cause for nephrolithiasis. We have thus concluded that Ceftriaxone by itself maybe a predisposing factor for nephrolithiasis.
Published: 2016

5. Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, El Bcheraoui, Charbel, Afshin, Ashkan, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Kassebaum, Nicholas J, Collison, Michael, Daoud, Farah, Krohn, Kristopher J, Chew, Adrienne, Biryukov, Stan H, Cornaby, Leslie, Foreman, Kyle J, Kutz, Michael, Liu, Patrick, Reitsma, Marissa, Sur, Patrick, Wang, Haidong, Zipkin, Ben, Arnlov, Johan, Abbafati, Cristiana, Abdulle, Abdishakur M, Abu-Rmeileh, Niveen ME, Ahmed, Muktar Beshir, Al-Aly, Ziyad, Alam, Khurshid, Alizadeh-Navaei, Reza, Alkerwi, Ala'a, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Baune, Bernhard T, Bedi, Neeraj, Bennett, Derrick A, Beyene, Addisu S, Bhutta, Zulfiqar A, Birhanu, Mulugeta M, Danawi, Hadi, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Gill, Paramjit Singh, Gona, Philimon N, Gupta, Vipin, Habtewold, Tesfa Dejenie, Hamadeh, Randah Ribhi, Hamidi, Samer, Hareri, Habtamu Abera, Horino, Masako, Hsairi, Mohamed, Javanbakht, Mehdi, John, Denny, Jonas, Jost B, Joshua, Vasna, Kasaeian, Amir, Ketema, Ezra B, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kinfu, Yohannes, Kokubo, Yoshihiro, Larson, Heidi J, Lee, Paul H, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Malekzadeh, Reza, Mate, Kedar K, Memish, Ziad A, Mengistie, Mubarek Abera, Mensah, George A, Ogbo, Felix Akpojene, Pourmalek, Farshad, Rafay, Anwar, Qorbani, Mostafa, Rahimi-Movaghar, Vafa, Rana, Saleem M, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Rezai, Mohammad Sadegh, Safdarian, Mahdi, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Milicevic, Milena M Santric, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shiri, Rahman, Santos Silva, Diego Augusto, Singh, Jasvinder A, Terkawi, Abdullah Sulieman, Tiruye, Tenaw Yimer, Ukwaja, Kingsley Nnanna, Vasankari, Tommi, Vlassov, Vasiliy Victorovich, Wakayo, Tolassa, Werdecker, Andrea, Yonemoto, Naohiro, Younis, Mustafa Z, Zein, Bassel, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Mokdad, Ali H, El Bcheraoui, Charbel, Afshin, Ashkan, Charara, Raghid, Ahmed, Muktar Beshir, Tiruye, Tenaw Yimer, Murray, Christopher JL, GBD 2015 Eastern Mediterranean Region Obesity Collaborators, Department of Public Health, Clinicum, University of Helsinki, Bennett, D, and Hay, S
Subjects: Male, obesity, Health (social science), 030204 cardiovascular system & hematology, Overweight, burden of disease, Obesity, Burden of disease, Eastern Mediterranean Region, Body Mass Index, Global Burden of Disease, 0302 clinical medicine, Epidemiology, 030212 general & internal medicine, Young adult, Child, 2. Zero hunger, Mediterranean Region, eastern mediterranean region, Middle Aged, 3142 Public health care science, environmental and occupational health, 3. Good health, PREVALENCE, 1117 Public Health And Health Services, Child, Preschool, Original Article, Female, Quality-Adjusted Life Years, SCHOOL-AGED CHILDREN, HEALTH, Public Health, medicine.symptom, Risk assessment, Adult, medicine.medical_specialty, Adolescent, Public Health, Environmental and Occupational Health, Risk Assessment, EGYPT, Middle East, Young Adult, 03 medical and health sciences, Environmental health, medicine, SYSTEMATIC ANALYSIS, Humans, METAANALYSIS, Aged, ENVIRONMENT, OVERWEIGHT, business.industry, MORTALITY, Environmental and Occupational Health, Klinisk medicin, medicine.disease, TRENDS, Quality-adjusted life year, Clinical Medicine, business, Body mass index, RC
Abstract: Objectives We used the Global Burden of Disease (GBD) 2015 study results to explore the burden of high body mass index (BMI) in the Eastern Mediterranean Region (EMR). Methods We estimated the prevalence of overweight and obesity among children (2–19 years) and adults (≥20 years) in 1980 and 2015. The burden of disease related to high BMI was calculated using the GBD comparative risk assessment approach. Results The prevalence of obesity increased for adults from 15.1% (95% UI 13.4–16.9) in 1980 to 20.7% (95% UI 18.8–22.8) in 2015. It increased from 4.1% (95% UI 2.9–5.5) to 4.9% (95% UI 3.6–6.4) for the same period among children. In 2015, there were 417,115 deaths and 14,448,548 disability-adjusted life years (DALYs) attributable to high BMI in EMR, which constitute about 10 and 6.3% of total deaths and DALYs, respectively, for all ages. Conclusions This is the first study to estimate trends in obesity burden for the EMR from 1980 to 2015. We call for EMR countries to invest more resources in prevention and health promotion efforts to reduce this burden. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1002-5) contains supplementary material, which is available to authorized users.
Published: 2018

6. Intentional injuries in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Moradi-Lakeh, Maziar, Charara, Raghid, El Bcheraoui, Charbel, Khalil, Ibrahim, Afshin, Ashkan, Kassebaum, Nicholas J, Collison, Michael, Chew, Adrienne, Krohn, Kristopher J, Daoud, Farah, Colombara, Danny, Graetz, Nicholas, Kutz, Michael, Wang, Haidong, Abd-Allah, Foad, Abu-Raddad, Laith J, Kiadaliri, Aliasghar Ahmad, Ahmed, Muktar Beshir, Alam, Khurshid, Alghnam, Suliman, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Anber, Nahla, Anwari, Palwasha, Avila-Burgos, Leticia, Awasthi, Ashish, Barac, Aleksandra, Barker-Collo, Suzanne L, Bedi, Neeraj, Bhutta, Zulfiqar A, Borschmann, Rohan, Boufous, Soufiane, Butt, Zahid A, Castaneda-Orjuela, Carlos A, Dalal, Koustuv, Danawi, Hadi, De Leo, Diego, Dharmaratne, Samath D, Djalalinia, Shirin, Doyle, Kerrie E, Esteghamati, Alireza, Faro, Andre, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Gutierrez, Reyna A, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Haro, Josep Maria, Hendrie, Delia, Hu, Guoqing, Jonas, Jost B, Kasaeian, Amir, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khubchandani, Jagdish, Kopec, Jacek A, Larson, Heidi J, Latif, Asma Abdul, Leshargie, Cheru Tesema, Lunevicius, Raimundas, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, Memish, Ziad A, Meretoja, Tuomo J, Miller, Ted R, Mohammed, Shafiu, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rawaf, David Laith, Rawaf, Salman, Rezaei, Satar, Rezai, Mohammad Sadegh, Roshandel, Gholamreza, Safdarian, Mahdi, Safiri, Saeid, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Seedat, Soraya, Sepanlou, Sadaf G, Shaikh, Masood Ali, Sobaih, Badr HA, Tabb, Karen M, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, RomanTopor-Madry, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Yaseri, Mehdi, NaohiroYonemoto, Younis, Mustafa Z, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Mokdad, AH, Moradi-Lakeh, M, Charara, R, Ahmed, M Beshir, Murray, C hristopher JL, GBD 2015 Eastern Mediterranean Region Intentional Injuries Collaborators, Department of Surgery, University of Helsinki, Clinicum, II kirurgian klinikka, Department of Oncology, and HUS Comprehensive Cancer Center
Subjects: Adult, Male, Burden of disease, SUICIDE, Health (social science), Adolescent, Scopus, Violence, Global Health, Global Burden of Disease, Middle East, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cost of Illness, Environmental health, parasitic diseases, Global health, Cost of illness, Humans, 030212 general & internal medicine, Young adult, CONFLICT, MORTALITY, Public Health, Environmental and Occupational Health, Eastern mediterranean region, Intentional injuries, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, 16. Peace & justice, 3142 Public health care science, environmental and occupational health, humanities, 3. Good health, Quality-adjusted life year, Eastern mediterranean, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Geography, 1117 Public Health And Health Services, Female, Original Article, Public Health, Quality-Adjusted Life Years, HEALTH, Self-Injurious Behavior, 030217 neurology & neurosurgery
Abstract: Objectives: We used GBD 2015 findings to measure the burden of intentional injuries in the Eastern Mediterranean Region (EMR) between 1990 and 2015. Methods: The Global Burden of Disease (GBD) study defines intentional injuries as a combination of self-harm (including suicide), interpersonal violence, collective violence (war), and legal intervention. We estimated number of deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for each type of intentional injuries. Results: In 2015, 28,695 individuals (95% UI: 25,474-37,832) died from self-harm, 35,626 (95% UI: 20,947-41,857) from interpersonal violence, and 143,858 (95% UI: 63,554-223,092) from collective violence and legal interventions. In 2015, collective violence and legal intervention was the fifth-leading cause of DALYs in the EMR and the leading cause in Syria, Yemen, Iraq, Afghanistan, and Libya; they account for 49.7% of total DALYs in Syria. Conclusions: Our findings call for increased efforts to stabilize the region and assist in rebuilding the health systems, as well as increasing transparency and employing preventive strategies to reduce self-harm and interpersonal injuries., Funding Agency:Bill & Melinda Gates Foundation
Published: 2018

7. Burden of diarrhea in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Khalil, Ibrahim, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Kassebaum, Nicholas J, Collison, Michael, Chew, Adrienne, Krohn, Kristopher J, Daoud, Farah, Colombara, Danny, Foreman, Kyle J, Godwin, William W, Kutz, Michael, Mirarefin, Mojde, Rao, Puja C, Jr, Reiner Robert, Troeger, Christopher, Wang, Haidong, Abraha, Haftom Niguse, Abu-Elyazeed, Remon, Abu-Raddad, Laith J, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Alam, Khurshid, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Anber, Nahla, Anwari, Palwasha, Atey, Tesfay Mehari, Avokpaho, Euripide Frinel G Arthur, Bacha, Umar, Bazargan-Hejazi, Shahrzad, Geffen, David, Bedi, Neeraj, Bensenor, Isabela M, Berhane, Adugnaw, Bessong, Pascal Obong, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Buckle, Geoffrey Colin, Butt, Zahid A, Danawi, Hadi, Deribew, Amare, Djalalinia, Shirin, Dubey, Manisha, Endries, Aman Yesuf, Eshrati, Babak, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Gugnani, Harish Chander, Hamadeh, Randah Ribhi, Hamidi, Samer, Husseini, Abdullatif, James, Spencer Lewis, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khubchandani, Jagdish, Kissoon, Niranjan, Kopec, Jacek A, Koyanagi, Ai, Defo, Barthelemy Kuate, Larson, Heidi J, Latif, Asma Abdul, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengistu, Desalegn Tadese, Mohammed, Shafiu, Murthy, Srinivas, Ngunjiri, Josephine Wanjiku, Ogbo, Felix Akpojene, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Ram, Usha, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Roshandel, Gholamreza, Safdarian, Mahdi, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shigematsu, Mika, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Sykes, Bryan L, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Tiruye, Tenaw Yimer, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Vollset, Stein Emil, Wakayo, Tolassa, Werdecker, Andrea, Wiysonge, Charles Shey, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yaseri, Mehdi, Yenesew, Muluken, Yonemoto, Naohiro, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Zodpey, Sanjay, Zein, Bassel, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Mokdad, AH, Khalil, I, El Bcheraoui, C, Beshir Ahmed, M, Tiruye, Tenaw Yimer, Murray, CJL, and GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
Subjects: Male, Health (social science), Psychological intervention, Eastern Mediterranean region, burden of disease, Global Health, Global Burden of Disease, 0302 clinical medicine, Risk Factors, Prevalence, Global health, 030212 general & internal medicine, Child, Mediterranean Region, Health Policy, Mortality rate, Burden of disease, MEDITERRÂNEO, Middle Aged, 3. Good health, Diarrhea, 1117 Public Health And Health Services, Child, Preschool, Original Article, Female, Quality-Adjusted Life Years, Public Health, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Eastern Mediterranean Region, Middle East, Young Adult, 03 medical and health sciences, Environmental health, medicine, Humans, Diarrheal diseases, Poverty, Health policy, Disease burden, Aged, business.industry, Public health, Public Health, Environmental and Occupational Health, Infant, Years of potential life lost, business
Abstract: Objectives Diarrheal diseases (DD) are an important cause of disease burden, especially in children in low-income settings. DD can also impact children’s potential livelihood through growth faltering, cognitive impairment, and other sequelae. Methods As part of the Global Burden of Disease study, we estimated DD burden, and the burden attributable to specific risk factors and etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2015. We calculated disability-adjusted life-years (DALYs)—the sum of years of life lost and years lived with disability—for both sexes and all ages. Results We estimate that over 103,692 diarrhea deaths occurred in the EMR in 2015 (95% uncertainty interval: 87,018–124,692), and the mortality rate was 16.0 deaths per 100,000 persons (95% UI: 13.4–19.2). The majority of these deaths occurred in children under 5 (63.3%) (65,670 deaths, 95% UI: 53,640–79,486). DALYs per 100,000 ranged from 304 (95% UI 228–400) in Kuwait to 38,900 (95% UI 25,900–54,300) in Somalia. Conclusions Our findings will guide evidence-based health policy decisions for interventions to achieve the ultimate goal of reducing the DD burden. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1008-z) contains supplementary material, which is available to authorized users.
Published: 2018

8. Transport injuries and deaths in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 Study

Author: Mokdad, Ali H, Khalil, Ibrahim, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Kassebaum, Nicholas J, Collison, Michael, Daoud, Farah, Chew, Adrienne, Krohn, Kristopher J, Colombara, Danny, Cornaby, Leslie, Ehrenkranz, Rebecca, Graetz, Nicholas, Kutz, Michael, Troeger, Christopher, Wang, Haidong, Abate, Kalkidan Hassen, Abd-Allah, Foad, Abdulle, Abdishakur M, Abera, Semaw Ferede, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Alam, Khurshid, Alasfoor, Deena, Alghnam, Suliman, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Philippines Palwasha, Asayesh, Hamid, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Barker-Collo, Suzanne L, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Boufous, Soufiane, Butt, Zahid A, Castaneda-Orjuela, Carlos A, Chitheer, Abdulaal A, Dalal, Koustuv, Danawi, Hadi, Davitoiu, Dragos V, Djalalinia, Shirin, Endries, Aman Yesuf, Eshrati, Babak, Esteghamati, Alireza, Faro, Andre, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gao, Wayne, Gebrehiwot, Tsegaye Tewelde, Hafezi-Nejad, Nima, Bidgoli, Hassan Haghparast, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hamidi, Samer, Hendrie, Delia, Heredia-Pi, Ileana Beatriz, Jacobsen, Kathryn H, James, Spencer Lewis, Jayatilleke, Achala Upendra, Jiang, Guohong, Jonas, Jost B, Kasaeian, Amir, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khubchandani, Jagdish, Kim, Yun Jin, Kosen, Soewarta, Defo, Barthelemy Kuate, Larson, Heidi J, Linn, Shai, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengistie, Mubarek Abera, Meretoja, Tuomo J, Miller, Ted R, Mohammed, Shafiu, Assaye, Ashagre Molla, Obermeyer, Carla Makhlouf, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranganathan, Kavitha, Rawaf, David Laith, Rawaf, Salman, Refaat, Amany H, Renzaho, Andre MN, Rezaei, Satar, Rojas-Rueda, David, Roshandel, Gholamreza, Safdarian, Mahdi, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Milicevic, Milena M Santric, Sartorius, Benn, Schwebel, David C, Sepanlou, Sadaf G, Shaheen, Amira, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sobaih, Badr HA, Sufiyan, Muawiyyah Babale, Sunshine, Jacob E, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, JS, Topor-Madry, Roman, Uthman, Olalekan A, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wakayo, Tolassa, Werdecker, Andrea, Yaghoubi, Mohsen, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Department of Surgery, University of Helsinki, Clinicum, II kirurgian klinikka, Department of Oncology, and HUS Comprehensive Cancer Center
Subjects: Male, Health (social science), Poison control, Global Health, Suicide prevention, Occupational safety and health, Global Burden of Disease, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Cause of death, CASUALTIES, OUTCOMES, Mediterranean Region, 030503 health policy & services, Accidents, Traffic, Burden of disease, Human factors and ergonomics, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, 3142 Public health care science, environmental and occupational health, 3. Good health, MEDICAL-TREATMENT, POLICE, OPPORTUNITIES, 1117 Public Health And Health Services, Original Article, Female, Public Health, Quality-Adjusted Life Years, HEALTH, 0305 other medical science, Adult, COUNTRIES, Adolescent, Eastern Mediterranean Region, Middle East, Young Adult, 03 medical and health sciences, EPIDEMIC, Environmental health, Injury prevention, Transport injuries, SYSTEMATIC ANALYSIS, Humans, ROAD-TRAFFIC INJURIES, Estimation, business.industry, Public Health, Environmental and Occupational Health, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Years of potential life lost, Wounds and Injuries, business
Abstract: Objectives Transport injuries (TI) are ranked as one of the leading causes of death, disability, and property loss worldwide. This paper provides an overview of the burden of TI in the Eastern Mediterranean Region (EMR) by age and sex from 1990 to 2015. Methods Transport injuries mortality in the EMR was estimated using the Global Burden of Disease mortality database, with corrections for ill-defined causes of death, using the cause of death ensemble modeling tool. Morbidity estimation was based on inpatient and outpatient datasets, 26 cause-of-injury and 47 nature-of-injury categories. Results In 2015, 152,855 (95% uncertainty interval: 137,900–168,100) people died from TI in the EMR countries. Between 1990 and 2015, the years of life lost (YLL) rate per 100,000 due to TI decreased by 15.5%, while the years lived with disability (YLD) rate decreased by 10%, and the age-standardized disability-adjusted life years (DALYs) rate decreased by 16%. Conclusions Although the burden of TI mortality and morbidity decreased over the last two decades, there is still a considerable burden that needs to be addressed by increasing awareness, enforcing laws, and improving road conditions. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-0987-0) contains supplementary material, which is available to authorized users.
Published: 2018

9. Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study

Author: Fitzmaurice, Christina, Alsharif, Ubai, El Bcheraoui, Charbel, Khalil, Ibrahim, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Collison, Michael, Chew, Adrienne, Krohn, Kristopher J, Daoud, Farah, Dicker, Daniel, Foreman, Kyle J, Frostad, Joseph, Kassebaum, Nicholas J, Kutz, Michael, Wang, Haidong, Abyu, Gebre Yitayih, Adedeji, Isaac Akinkunmi, Kiadaliri, Aliasghar Ahmad, Ahmed, Muktar Beshir, Al-Eyadhy, Ayman, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amini, Erfan, Anber, Nahla, Anwari, Palwasha, Artaman, Al, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mehari, Awasthi, Ashish, Saleem, Huda Omer Ba, Bacha, Umar, Barac, Aleksandra, Bedi, Neeraj, Bhutta, Zulfiqar A, Butt, Zahid A, Castaneda-Orjuela, Carlos A, Chitheer, Abdulaal A, Danawi, Hadi, das Neves, Jose, Davitoiu, Dragos V, Dey, Subhojit, Dharmaratne, Samath D, Djalalinia, Shirin, Do, Huyen Phuc, Dubey, Manisha, Ebrahimi, Hedyeh, Ekwueme, Donatus U, Endries, Aman Yesuf, Eshrati, Babak, Esteghamati, Alireza, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Gopalani, Sameer Vali, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Hareri, Habtamu Abera, Hay, Roderick J, Horita, Nobuyuki, Hsairi, Mohamed, Jakovljevic, Mihajlo B, Jonas, Jost B, Kasaeian, Amir, Kassaw, Nigussie Assefa, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Kim, Daniel, Kinfu, Yohannes, Larson, Heidi J, Latif, Asma Abdul, Linn, Shai, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Markos, Desalegn, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Tuomo J, Miller, Ted R, Mohammed, Shafiu, Nangia, Vinay, Nguyen, Quyen Le, Nguyen, Trang Huyen, Ogbo, Felix Akpojene, Mahesh, PA, Park, Eun-Kee, Patel, Tejas, Pereira, David M, Pishgar, Farhad, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Roba, Kedir Teji, Roshandel, Gholamreza, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Milicevic, Milena M Santric, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shrime, Mark G, Stathopoulou, Vasiliki, Sufiyan, Muawiyyah Babale, Abdulkader, Rizwan Suliankatchi, Tabares-Seisdedos, Rafael, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Temsah, Mohamad-Hani, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wakayo, Tolassa, Weiderpass, Elisabete, Werdecker, Andrea, Yaghoubi, Mohsen, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Zaki, Maysaa El Sayed, Zein, Bassel, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Mokdad, Ali H, Reg, GBD 2015 Eastern Mediterranean, Instituto de Investigação e Inovação em Saúde, Alsharif, U, El Bcheraoui, C, Khalil, I, Charara, R, Ahmed, MB, Fitzmaurice, C, Department of Surgery, University of Helsinki, II kirurgian klinikka, Clinicum, Department of Oncology, and HUS Comprehensive Cancer Center
Subjects: Health (social science), Palliative care, Global Health, Mediterranean Region / epidemiology, Eastern Mediterranean Region, Disability-adjusted life years, Global Burden of Disease, Middle East, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Neoplasms / economics, Neoplasms, MIDDLE-INCOME COUNTRIES, Environmental health, medicine, cancer, Humans, 030212 general & internal medicine, Mortality, Lung cancer, Disease burden, Global Burden of Disease / statistics & numerical data, Cancer, Cancer prevention, Mediterranean Region, business.industry, Incidence (epidemiology), Incidence, DEATH, Public Health, Environmental and Occupational Health, CARE, medicine.disease, mortality, 3142 Public health care science, environmental and occupational health, Neoplasms / mortality, 3. Good health, Cancer registry, 1117 Public Health And Health Services, 030220 oncology & carcinogenesis, Original Article, Public Health, Neoplasms / epidemiology, Quality-Adjusted Life Years, business, Middle East / epidemiology
Abstract: Objectives: To estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015. Methods: Vital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology. Results: In 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs by 31%. The increase in cancer incidence was largely driven by population growth and population aging. Breast cancer, lung cancer, and leukemia were the most common cancers, while lung, breast, and stomach cancers caused most cancer deaths. Conclusions: Cancer is responsible for a substantial disease burden in the EMR, which is increasing. There is an urgent need to expand cancer prevention, screening, and awareness programs in EMR countries as well as to improve diagnosis, treatment, and palliative care services. The funding source played no role in the design of thestudy, the analysis and interpretation of data, and the writing of thepaper. GBD 2015 is funded by Bill & Melinda Gates Foundation.
Published: 2018

10. Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Krohn, Kristopher J, Daoud, Farah, Chew, Adrienne, Kassebaum, Nicholas J, Colombara, Danny, Cornaby, Leslie, Ehrenkranz, Rebecca, Foreman, Kyle J, Fraser, Maya, Frostad, Joseph, Kemmer, Laura, Kulikoff, Xie Rachel, Kutz, Michael, Kyu, Hmwe H, Liu, Patrick, Mikesell, Joseph, Nguyen, Grant, Rao, Puja C, Silpakit, Naris, Sligar, Amber, Smith, Alison, Stanaway, Jeffrey D, Arnlov, Johan, Abate, Kalkidan Hassen, Kiadaliri, Aliasghar Ahmad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Alraddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Anber, Nahla, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Artaman, Al, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Azzopardi, Peter, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Bedi, Neeraj, Beghi, Ettore, Bennett, Derrick A, Bhutta, Zulfiqar A, Bisanzio, Donal, Castaneda-Orjuela, Carlos A, Estanislao Castro, Ruben, Danawi, Hadi, Deribe, Kebede, Deribew, Amare, Jarlais, Don C Des, deVeber, Gabrielle A, Dey, Subhojit, Dharmaratne, Samath D, Djalalinia, Shirin, Do, Huyen Phuc, Esteghamati, Alireza, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Giussani, Giorgia, Gona, Philimon N, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Hoy, Damian G, Hu, Guoqing, John, Denny, Jonas, Jost B, Karimi, Seyed M, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Kim, Daniel, Kim, Yun Jin, Kinfu, Yohannes, Larson, Heidi J, Latif, Asma Abdul, Leasher, Janet L, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majeed, Azeem, Malekzadeh, Reza, Memish, Ziad A, Mendoza, Walter, Mezgebe, Haftay Berhane, Miller, Ted R, Monasta, Lorenzo, Nguyen, Quyen Le, Obermeyer, Carla Makhlouf, Ortiz, Alberto, Papachristou, Christina, Park, Eun-Kee, Pereira, Claudia C, Petzold, Max, Pereira, David M, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Rezai, Mohammad Sadegh, Ronfani, Luca, Roshandel, Gholamreza, Ruhago, George Mugambage, Safdarian, Mahdi, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Sartorius, Benn, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Setegn, Tesfaye, Shaheen, Amira, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shiri, Rahman, Skirbekk, Vegard, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Thakur, Arabia JS, Thomson, Alan J, Tran, Bach Xuan, Truelsen, Thomas, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vasankari, Tommi, Vlassov, Vasiliy Victorovich, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Yaghoubi, Mohsen, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Wang, Haidong, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Department of Public Health, Clinicum, and University of Helsinki
Subjects: Male, PNEUMONIA, Pediatrics, Health (social science), Poison control, 030204 cardiovascular system & hematology, Infant mortality, Global Health, Global Burden of Disease, 0302 clinical medicine, Neonatal, Global health, LIFE EXPECTANCY, 030212 general & internal medicine, health care economics and organizations, Mediterranean Region, Child Health, Burden of disease, 3142 Public health care science, environmental and occupational health, 3. Good health, UPDATED SYSTEMATIC ANALYSIS, 1117 Public Health And Health Services, Child, Preschool, Female, Original Article, Public Health, CHILD-MORTALITY, INTERVENTIONS, COUNTRIES, Child mortality, medicine.medical_specialty, INTEGRATED APPROACH, Eastern Mediterranean Region, 03 medical and health sciences, Middle East, Neonatal mortality, Environmental health, Injury prevention, medicine, Humans, PROGRESS, Perinatal Mortality, METAANALYSIS, business.industry, Public Health, Environmental and Occupational Health, Infant, Newborn, Klinisk medicin, Infant, DIARRHEA, mortality, Eastern mediterranean, Life expectancy, Morbidity, Clinical Medicine, business
Abstract: Objectives Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. Methods We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. Results In 2015, 755,844 (95% uncertainty interval (UI) 712,064–801,565) children under 5 died in the EMR. In the early neonatal category, deaths in the EMR decreased by 22.4%, compared to 42.4% globally. The rate of years of life lost per 100,000 population under 5 decreased 54.38% from 177,537 (173,812–181,463) in 1990 to 80,985 (76,308–85,876) in 2015; the rate of years lived with disability decreased by 0.57% in the EMR compared to 9.97% globally. Conclusions Our findings call for accelerated action to decrease child morbidity and mortality in the EMR. Governments and organizations should coordinate efforts to address this burden. Political commitment is needed to ensure that child health receives the resources needed to end preventable deaths. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-0998-x) contains supplementary material, which is available to authorized users.
Published: 2018

11. Maternal mortality and morbidity burden in the Eastern Mediterranean Region : findings from the Global Burden of Disease 2015 study

Author: Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraoui, Charbel, Charara, Raghid, Moradi-Lakeh, Maziar, Afshin, Ashkan, Chew, Adrienne, Daoud, Farah, Krohn, Kristopher J, Colombara, Danny, Ehrenkranz, Rebecca, Kutz, Michael, Wang, Haidong, Abajobir, Amanuel Alemu, Abd-Allah, Foad, Abraha, Haftom Niguse, Abu-Raddad, Laith J, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Kedir Yimam, Ahmed, Muktar Beshir, Al Lami, Faris Hasan, Alam, Khurshid, Alasfoor, Deena, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Al-Maskari, Fatma, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Asayesh, Hamid, Asghar, Rana Jawad, Atey, Tesfay Mehari, Ayele, Tadesse Awoke, Baernighausen, Till, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Geffen, David, Bedi, Neeraj, Bensenor, Isabela M, Berhane, Adugnaw, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Boneya, Dube Jara, Borschmann, Rohan, Breitborde, Nicholas JK, Butt, Zahid A, Catala-Lopez, Ferran, Ciobanu, Liliana G, Danawi, Hadi, Deribew, Amare, Dharmaratne, Samath D, Doyle, Kerrie E, Endries, Aman Yesuf, Faraon, Emerito Jose Aquino, Faro, Andre, Farvid, Maryam S, Fekadu, Wubalem, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Giref, Ababi Zergaw, Gishu, Melkamu Dedefo, Goulart, Alessandra Carvalho, Habtewold, Tesfa Dejenie, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Maria Haro, Josep, Hassanvand, Mohammad Sadegh, Horita, Nobuyuki, Hsairi, Mohamed, Huang, Hsiang, Husseini, Abdullatif, Jakovljevic, Mihajlo B, James, Spencer Lewis, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kokubo, Yoshihiro, Koyanagi, Ai, Defo, Barthelemy Kuate, Larson, Heidi J, Latif, Asma Abdul, Lee, Paul H, Leshargie, Cheru Tesema, Leung, Ricky, Lo, Loon-Tzian, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Martinez-Raga, Jose, Farid, Habibolah Masoudi, Mazidi, Mohsen, McGrath, John J, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mensah, George A, Mezgebe, Haftay Berhane, Miller, Ted R, Mitchell, Philip B, Mohammadi, Alireza, Mohammed, Shafiu, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Palomares Castillo, Elizabeth, Papachristou, Christina, Patten, Scott B, Patton, George C, Pereira, David M, Pervaiz, Aslam, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rawaf, David Laith, Rawaf, Salman, Refaat, Amany H, Rezaei, Satar, Rezai, Mohammad Sadegh, Roshandel, Gholamreza, Safdarian, Mahdi, Safiabadi, Mahdi, Safiri, Saeid, Sagar, Rajesh, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Saylan, Mete I, Seedat, Soraya, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shamsizadeh, Morteza, Santos Silva, Diego Augusto, Singh, Jasvinder A, Sobaih, Badr HA, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Abdulkader, Rizwan Suliankatchi, Sykes, Bryan L, Tabares-Seisdedos, Rafael, Sufiyan, Muawiyyah, Tabb, Karen M, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vollset, Stein Emil, Wakayo, Tolassa, Wang, Yuan-Pang, Werdecker, Andrea, Westerman, Ronny, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yimam, Hassen Hamid, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Kassebaum, Nicholas J, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, UCH. Departamento de Farmacia, Producción Científica UCH 2018, Mokdad, Ali H, Khalil, Ibrahim, Collison, Michael, El Bcheraou, Charbel, Ciobanu, Liliana G, and Murray, Christopher JL
Subjects: Adult, Burden of disease, Maternal mortality, medicine.medical_specialty, Health (social science), Psychological intervention, SAÚDE DA MULHER, Global Health, maternal health, Eastern Mediterranean Region, Global Burden of Disease, Middle East, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Global health, Journal Article, Humans, 030212 general & internal medicine, 030219 obstetrics & reproductive medicine, Mediterranean Region, maternal mortality, business.industry, Public health, Age Factors, 1. No poverty, Public Health, Environmental and Occupational Health, Reproductive life, 3. Good health, Eastern mediterranean, Pregnant women - Mortality - Eastern Mediterranean, Standardized mortality ratio, 1117 Public Health And Health Services, Life expectancy, Mujeres embarazadas - Mortalidad - Mediterráneo oriental (Región), Original Article, Female, Public Health, Maternal health, Morbidity, business
Abstract: Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://link.springer.com/article/10.1007%2Fs00038-017-1004-3 Este artículo forma parte del suplemento titulado "The state of health in the Eastern Mediterranean Region, 1990-2015". Objectives Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015. Methods We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR countries. Results The maternal mortality ratio in the EMR decreased 16.3% from 283 (241–328) maternal deaths per 100,000 live births in 1990 to 237 (188–293) in 2015. Maternal mortality ratio was strongly correlated with socio-demographic status, where the lowest-income countries contributed the most to the burden of maternal mortality in the region. Conclusion Progress in reducing maternal mortality in the EMR has accelerated in the past 15 years, but the burden remains high. Coordinated and rigorous efforts are needed to make sure that adequate and timely services and interventions are available for women at each stage of reproductive life.
Published: 2018

12. The burden of mental disorders in the Eastern Mediterranean region, 1990-2015 : findings from the global burden of disease 2015 study

Author: Mokdad, Ali H, Charara, Raghid, El Bcheraoui, Charbel, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Afshin, Ashkan, Kassebaum, Nicholas J, Collison, Michael, Krohn, Kristopher J, Chew, Adrienne, Daoud, Farah, Charlson, Fiona J, Colombara, Danny, Degenhardt, Louisa, Ehrenkranz, Rebecca, Erskine, Holly E, Ferrari, Alize J, Kutz, Michael, Leung, Janni, Santomauro, Damian, Wang, Haidong, Whiteford, Harvey A, Abajobir, Amanuel Alemu, Abd-Allah, Foad, Abraha, Haftom Niguse, Abu-Raddad, Laith J, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Yimam, Kedir, Beshir, Muktar, Al Lami, Faris Hasan, Alam, Khurshid, Alasfoor, Deena, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Al-Maskari, Fatma, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Asayesh, Hamid, Asghar, Rana Jawad, Atey, Tesfay Mehari, Ayele, Tadesse Awoke, Baernighausen, Till, Bacha, Umar, Barac, Aleksandra, Barker-Collo, Suzanne L, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Drew, Charles R, Geffen, David, Bedi, Neeraj, Bensenor, Isabela M, Berhane, Adugnaw, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Boneya, Dube Jara, Borschmann, Rohan, Breitborde, Nicholas JK, Butt, Zahid A, Catala-Lopez, Ferran, Ciobanu, Liliana G, Danawi, Hadi, Deribew, Amare, Dharmaratne, Samath D, Doyle, Kerrie E, Endries, Aman Yesuf, Faraon, Emerito Jose Aquino, Faro, Andre, Farvid, Maryam S, Fekadu, Wubalem, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Giref, Ababi Zergaw, Gishu, Melkamu Dedefo, Carvalho, Alessandra, Habtewold, Tesfa Dejenie, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Horita, Nobuyuki, Hsairi, Mohamed, Huang, Hsiang, Husseini, Abdullatif, Jakovljevic, Mihajlo B, James, Spencer Lewis, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khubchandani, Jagdish, Kim, Daniel, Kim, Yun Jin, Kokubo, Yoshihiro, Koyanagi, Ai, Defo, Barthelemy Kuate, Larson, Heidi J, Latif, Asma Abdul, Lee, Paul H, Leshargie, Cheru Tesema, Leung, Ricky, Lo, Loon-Tzian, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Martinez-Raga, Jose, Farid, Habibolah Masoudi, Mazidi, Mohsen, McGrath, John J, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mezgebe, Haftay Berhane, Miller, Ted R, Mitchell, Philip B, Mohammadi, Alireza, Mohammed, Shafiu, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Castillo, Elizabeth Palomares, Papachristou, Christina, Patten, Scott B, Patton, George C, Pervaiz, Aslam, Phillips, Michael Robert, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rawaf, David Laith, Rawaf, Salman, Refaat, Amany H, Rezaei, Satar, Rezai, Mohammad Sadegh, Roshandel, Gholamreza, Safdarian, Mahdi, Safiabadi, Mahdi, Safiri, Saeid, Sagar, Rajesh, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Saylan, Mete I, Seedat, Soraya, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shamsizadeh, Morteza, Silva, Diego Augusto Santos, Singh, Jasvinder A, Sobaih, Badr HA, Stein, Dan J, Abdulkader, Rizwan Suliankatchi, Sykes, Bryan L, Tabares-Seisdedos, Rafael, Tabb, Karen M, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vollset, Stein Emil, Wakayo, Tolassa, Wang, Yuan-Pang, Werdecker, Andrea, Westerman, Ronny, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yimam, Hassen Hamid, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa El Sayed, Zein, Bassel, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, UCH. Departamento de Farmacia, Producción Científica UCH 2018, Hay, S, Mokdad, Ali H, Charara, Raghid, El Bcheraoui, Charbel, Khalil, Ibrahim, Ciobanu, Liliana G, and Murray, Christopher JL
Subjects: Male, Health (social science), Eastern Mediterranean region, Poison control, burden of disease, Global Health, Global Burden of Disease, Depression, Mental - Eastern Mediterranean, 0302 clinical medicine, Risk Factors, Global health, Medicine, 030212 general & internal medicine, Mental illness - Eastern Mediterranean, Mediterranean Region, Mental Disorders, Epidemiología psiquiátrica, Burden of disease, Middle Aged, 3. Good health, 1117 Public Health And Health Services, Anxiety, Original Article, Mental health, Female, Quality-Adjusted Life Years, Public Health, medicine.symptom, mental health, Adult, Depressive disorders, medicine.medical_specialty, Adolescent, Anxiety - Eastern Mediterranean, Mental health - Eastern Mediterranean, Middle East, Young Adult, 03 medical and health sciences, anxiety disorders, Injury prevention, Journal Article, Humans, Depresión mental - Mediterráneo oriental (Región), Psychiatry, Disease burden, Aged, DEPRESSÃO, business.industry, Public health, Enfermedades mentales - Mediterráneo oriental (Región), Public Health, Environmental and Occupational Health, Salud mental - Mediterráneo oriental (Región), Ansiedad - Mediterráneo oriental (Región), 030227 psychiatry, Quality-adjusted life year, Psychiatric epidemiology, depressive disorders, business, Anxiety disorders
Abstract: Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://link.springer.com/article/10.1007%2Fs00038-017-1006-1 Este artículo forma parte del suplemento titulado "The state of health in the Eastern Mediterranean Region, 1990-2015". Objectives. Mental disorders are among the leading causes of nonfatal burden of disease globally. Methods. We used the global burden of diseases, injuries, and risk factors study 2015 to examine the burden of mental disorders in the Eastern Mediterranean region (EMR). We defined mental disorders according to criteria proposed in the diagnostic and statistical manual of mental disorders IV and the 10th International Classification of Diseases. Results Mental disorders contributed to 4.7% (95% uncertainty interval (UI) 3.7–5.6%) of total disability-adjusted life-years (DALYs), ranking as the ninth leading cause of disease burden. Depressive disorders and anxiety disorders were the third and ninth leading causes of nonfatal burden, respectively. Almost all countries in the EMR had higher age-standardized mental disorder DALYs rates compared to the global level, and in half of the EMR countries, observed mental disorder rates exceeded the expected values. Conclusions The burden of mental disorders in the EMR is higher than global levels, particularly for women. To properly address this burden, EMR governments should implement nationwide quality epidemiological surveillance of mental disorders and provide adequate prevention and treatment services.
Published: 2018

13. Danger ahead: the burden of diseases, injuries, and risk factors in the Eastern Mediterranean Region, 1990–2015

Author: Mokdad, Ali H, El Bcheraoui, Charbel, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Afshin, Ashkan, Collison, Michael, Daoud, Farah, Krohn, Kristopher J, Chew, Adrienne, Biryukov, Stan, Casey, Daniel, Cercy, Kelly, Charlson, Fiona J, Cornaby, Leslie, Dicker, Daniel, Erskine, Holly E, Ferrari, Alize J, Fitzmaurice, Christina, Foreman, Kyle J, Fraser, Maya, Frostad, Joseph, Godwin, William W, Griswold, Max, Kassebaum, Nicholas J, Kemmer, Laura, Kutz, Michael, Kyu, Hmwe H, Leung, Janni, Liu, Patrick, Mikesell, Joseph, Nguyen, Grant, Olsen, Helen E, Reiner, Robert, Reitsma, Marissa, Roth, Gregory, Santomauro, Damian, Smith, Alison, Stanaway, Jeffrey D, Sur, Patrick, Wang, Haidong, Whiteford, Harvey A, Afifi, Rima, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmadieh, Hamid, Alam, Khurshid, Alam, Noore, Ali, Raghib, Alizadeh-Navaei, Reza, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Anber, Nahla, Ansari, Hossein, Anwari, Palwasha, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Bacha, Umar, Bazargan-Hejazi, Shahrzad, Geffen, David, Bedi, Neeraj, Bhutta, Zulfiqar A, Bisanzio, Donal, Butt, Zahid A, Deribew, Amare, Djalalinia, Shirin, Eshrati, Babak, Esteghamati, Alireza, Farvid, Maryam S, Chan, Harvard TH, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Gebrehiwot, Tsegaye T, Hafezi-Nejad, Nima, Hamadeh, Randah R, Hamidi, Samer, Hotez, Peter J, Hsairi, Mohamed, Jonas, Jost B, Kasaeian, Amir, Khader, Yousef S, Khan, Ejaz A, Khan, Gulfaraz, Khoja, Abdullah TA, Khoja, Tawfik AM, Khubchandani, Jagdish, Kopec, Jacek A, Larson, Heidi J, Lunevicius, Raimundas, Abd El Razek, Hassan Magdy, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Memish, Ziad A, Mensah, George A, Nasher, Jamal T, Obermeyer, Carla M, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rawaf, David L, Rawaf, Salman, Refaat, Amany H, Rezaei, Satar, Roshandel, Gholamreza, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood A, Shamsizadeh, Morteza, Sobaih, Badr HA, Abdulkader, Rizwan Suliankatchi, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah S, Topor-Madry, Roman, Uthman, Olalekan A, Vollset, Stein Emil, Werdecker, Andrea, Yaghoubi, Mohsen, Yaseri, Mehdi, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Naghavi, Mohsen, Hay, Simon I, Murray, Christopher JL, and Reg, GBD 2015 Eastern Mediterranean
Subjects: medicine.medical_specialty, Health (social science), Poison control, Nutritional Status, 030209 endocrinology & metabolism, Disease, Global Health, Eastern Mediterranean Region, Disability-adjusted life years, Child Nutrition Disorders, Occupational safety and health, Global Burden of Disease, 03 medical and health sciences, Middle East, 0302 clinical medicine, Environmental health, Neoplasms, Injury prevention, medicine, Diabetes Mellitus, Humans, 030212 general & internal medicine, Risk factor, Child, Noncommunicable Diseases, Cause of death, 2. Zero hunger, Injuries, business.industry, Mediterranean Region, Public health, Public Health, Environmental and Occupational Health, Burden of disease, medicine.disease, 3. Good health, Diet, Malnutrition, Risk factors, 1117 Public Health And Health Services, Original Article, Quality-Adjusted Life Years, Public Health, business
Abstract: Objectives The Eastern Mediterranean Region faces several health challenges at a difficult time with wars, unrest, and economic change. Methods We used the Global Burden of Disease 2015 study to present the burden of diseases, injuries, and risk factors in the Eastern Mediterranean Region from 1990 to 2015. Results Ischemic heart disease was the leading cause of death in the region in 2015, followed by cerebrovascular disease. Changes in total deaths ranged from a reduction of 25% for diarrheal diseases to an increase of about 42% for diabetes and tracheal, bronchus, and lung cancer. Collective violence and legal intervention increased by 850% during the time period. Diet was the leading risk factor for disability-adjusted life years (DALYs) for men compared to maternal malnutrition for females. Childhood undernutrition was the leading risk factor for DALYs in 1990 and 2005, but the second in 2015 after high blood pressure. Conclusions Our study shows that the region is facing several health challenges and calls for global efforts to stabilise the region and to address the current and future burden of disease. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1017-y) contains supplementary material, which is available to authorized users.
Published: 2017

14. International Journal of Public Health

Author: Mokdad, Ali H, El Bcheraoui, Charbel, Wang, Haidong, Charara, Raghid, Khalil, Ibrahim, Moradi-Lakeh, Maziar, Afshin, Ashkan, Collison, Michael, Daoud, Farah, Chew, Adrienne, Krohn, Kristopher J, Carter, Austin, Foreman, Kyle J, He, Fei, Kassebaum, Nicholas J, Kutz, Michael, Mirarefin, Mojde, Nguyen, Grant, Silpakit, Naris, Sligar, Amber, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Adane, Kelemework, Agarwal, Arnav, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Al Lami, Faris Hasan, Alam, Khurshid, Alasfoor, Deena, Alizadeh-Navaei, Reza, Al-Maskari, Fatma, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Ammar, Walid, Anber, Nahla, Antonio, Carl Abelardo T, Anwari, Palwasha, Asayesh, Hamid, Asghar, Rana Jawad, Atey, Tesfay Mehari, Avokpaho, Euripide Frinel G Arthur, Ayele, Tadesse Awoke, Azzopardi, Peter, Bacha, Umar, Barac, Aleksandra, Baernighausen, Till, Bazargan-Hejazi, Shahrzad, Geffen, David, Bedi, Neeraj, Bensenor, Isabela M, Berhane, Adugnaw, Bessong, Pascal Obong, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Birungi, Charles, Butt, Zahid A, Cahuana-Hurtado, Lucero, Danawi, Hadi, das Neves, Jose, Deribe, Kebede, Deribew, Amare, Jarlais, Don C Des, Dharmaratne, Samath D, Djalalinia, Shirin, Doyle, Kerrie E, Endries, Aman Yesuf, Eshrati, Babak, Faraon, Emerito Jose Aquino, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Feyissa, Tesfaye Regassa, Fischer, Florian, Garcia-Basteiro, Alberto L, Gebrehiwot, Tsegaye Tewelde, Gesesew, Hailay Abrha, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Gona, Philimon N, Gugnani, Harish Chander, Gupta, Rahul, Bidgoli, Hassan Haghparast, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Harb, Hilda L, Hareri, Habtamu Abera, Horita, Nobuyuki, Husseini, Abdullatif, Ibrahim, Ahmed, James, Spencer Lewis, Jonas, Jost B, Kasaeian, Amir, Kassaw, Nigussie Assefa, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khoja, Abdullah Tawfih Abdullah, Khubchandani, Jagdish, Kim, Yun Jin, Koyanagi, Ai, Defo, Barthelemy Kuate, Larson, Heidi J, Latif, Asma Abdul, Leshargie, Cheru Tesema, Lunevicius, Raimundas, Abd El Razek, Mohammed Magdy, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Manyazewal, Tsegahun, Markos, Desalegn, Farid, Habibolah Masoudi, Mehari, Alem, Mekonnen, Alemayehu B, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Mezgebe, Haftay Berhane, Mhimbira, Francis Apolinary, Miller, Ted R, Moore, Ami R, Mumtaz, Ghina R, Natarajan, Gopalakrishnan, Negin, Joel, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Ota, Erika, Pereira, David M, Pourmalek, Farshad, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Ram, Usha, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre MN, Rezaei, Satar, Rezai, Mohammad Sadegh, Roba, Hirbo Shore, Roshandel, Gholamreza, Safdarian, Mahdi, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Shamsizadeh, Morteza, Sibamo, Ephrem Lejore Sibamo, Singh, Jasvinder A, Sobaih, Badr HA, Soshnikov, Sergey, Sufiyan, Muawiyyah Babale, Sykes, Bryan L, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Shifa, Girma Temam, Temsah, Mohamad-Hani, Tesssema, Belay, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vollset, Stein Emil, Wadilo, Fiseha, Wakayo, Tolassa, Alebachew, Minyahil, Workicho, Abdulhalik, Workie, Shimelash Bitew, Yaghoubi, Mohsen, Yalew, Ayalnesh Zemene, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaki, Maysaa El Sayed, Jumaan, Aisha O, Vos, Theo, Hay, Simon I, Naghavi, Mohsen, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, and Instituto de Investigação e Inovação em Saúde
Subjects: Health (social science), HIV Infections, Global Health, Mediterranean Region / epidemiology, Global Burden of Disease, HIV Infections / epidemiology, 0302 clinical medicine, Prevalence, 030212 general & internal medicine, Global Burden of Disease / statistics & numerical data, education.field_of_study, HIV mortality, Mediterranean Region, Mortality rate, Burden of disease, MEDITERRÂNEO, 3. Good health, 1117 Public Health And Health Services, Original Article, Public Health, Life Expectancy / trends, 0305 other medical science, medicine.medical_specialty, Acquired Immunodeficiency Syndrome / epidemiology, Population, Acquired Immunodeficiency Syndrome / economics, Eastern Mediterranean Region, 03 medical and health sciences, Middle East, Life Expectancy, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, Mortality, education, Acquired Immunodeficiency Syndrome, 030505 public health, business.industry, Public health, Body Weight, Public Health, Environmental and Occupational Health, HIV, Sequela, medicine.disease, Years of potential life lost, Life expectancy, Morbidity, business, HIV Infections / economics, Demography, Middle East / epidemiology
Abstract: Objectives We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Methods Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with disability (YLDs) were computed as the prevalence of a sequela multiplied by its disability weight. Results In 2015, the rate of HIV/AIDS deaths in the EMR was 1.8 (1.4–2.5) per 100,000 population, a 43% increase from 1990 (0.3; 0.2–0.8). Consequently, the rate of YLLs due to HIV/AIDS increased from 15.3 (7.6–36.2) per 100,000 in 1990 to 81.9 (65.3–114.4) in 2015. The rate of YLDs increased from 1.3 (0.6–3.1) in 1990 to 4.4 (2.7–6.6) in 2015. Conclusions HIV/AIDS morbidity and mortality increased in the EMR since 1990. To reverse this trend and achieve epidemic control, EMR countries should strengthen HIV surveillance, and scale up HIV antiretroviral therapy and comprehensive prevention services. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1023-0) contains supplementary material, which is available to authorized users.
Published: 2017

15. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015 : a systematic analysis for the Global Burden of Disease Study 2015

Author: Vasiliki Stathopoulou, Kiran Thapa, Vesper Hichilombwe Chisumpa, Azeem Majeed, Hjalte Holm Andersen, Devasahayam J. Christopher, Alireza Mohammadi, John J. McGrath, Konstantin Kazanjan, Naohiro Yonemoto, Guoqing Hu, Yousef Khader, Suzanne Barker-Collo, Frida Namnyak Ngalesoni, Jennifer O Lam, Laetitia Huiart, Xiaofeng Liang, Amanuel Tesfay Gebremedhin, Lalit Dandona, Felix Masiye, Joseph R Fitchett, Derrick A Bennett, Rosana E. Norman, Theo Vos, Tuomo J. Meretoja, Rahman Shiri, Melvin Barrientos Marzan, Charles R. Newton, Kelly Cercy, Masoud Vaezghasemi, Elena Alvarez Martin, Christopher Troeger, Ismael R. Campos-Nonato, Amany H Refaat, Ruben Castro, Amiran Gamkrelidze, Michael R. Phillips, Samath D Dharmaratne, Reed J D Sorensen, Roderick J. Hay, Johan Ärnlöv, Ivo Rakovac, Alexandra Brazinova, Nancy Fullman, Sara Sheikhbahaei, Liliana G Ciobanu, Nader Jahanmehr, Yuming Guo, Luigi Naldi, Rana Jawad Asghar, Tsegaye Tewelde Gebrehiwot, Corine Karema, Biju Abraham, Rynaz H S Rabiee, Emerito Jose A. Faraon, Philimon Gona, Jonathan I. Silverberg, Alexandria Brown, Kovin Naidoo, Suleman Atique, Yun Jin Kim, Benn Sartorius, Hwashin Hyun Shin, George Mugambage Ruhago, Adugnaw Berhane, Tesfaye Tekle, Abdur Rahman Khan, Vipin Gupta, Nima Hafezi-Nejad, Héctor Gómez-Dantés, Jun She, Ted R. Miller, Tolesa Bekele, Yohannes Kinfu, Srinivas Murthy, Alaa Badawi, Mahfuzar Rahman, Raghib Ali, Robert G. Weintraub, Nicholas Steel, Khalid A Altirkawi, Muhammad Imran Nisar, Man Mohan Mehndiratta, Thomas N. Williams, Adrian Davis, Usha Ram, Nobuyuki Horita, Qingyang Xiao, Bishal Gyawali, Burcu Kucuk Bicer, Eun-Kee Park, Subas Neupane, Mohammad Tavakkoli, Lorenzo Monasta, Roman Topor-Madry, Marc-Alain Widdowson, James Leigh, Padukudru Anand Mahesh, Stephen M. Amrock, Stefan Ma, Virendra Singh, Amir Kasaeian, Mahdi Mahdavi, Shahrzad Bazargan-Hejazi, Kim Moesgaard Iburg, Vafa Rahimi-Movaghar, Julio Cesar Campuzano, Maria Dolores Sanchez-Niño, Jean B. Nachega, Hamid Asayesh, Pratik Pinal Doshi, Charles Shey Wiysonge, Peter J. Hotez, Ying Jiang, Girma Temam Shifa, Warren D. Lo, Francis Apolinary Mhimbira, Joan B. Soriano, Ritul Kamal, Young-Ho Khang, Isaac Akinkunmi Adedeji, Daniel C Casey, Adeladza Kofi Amegah, Demewoz Haile, Tomi Akinyemiju, Andrew L. Thorne-Lyman, Achala Upendra Jayatilleke, Rajeev Gupta, Rosario Cárdenas, Peter W. Gething, Ami R. Moore, Marie Ng, Maigeng Zhou, Ferrán Catalá-López, Anders Larsson, Ratilal Lalloo, Panniyammakal Jeemon, Bach Xuan Tran, Chigozie Jesse Uneke, Marina Shakh-Nazarova, Jamie Hancock, Yohannes Adama Melaku, Jasvinder A. Singh, Isabela M. Benseñor, Shafiu Mohammed, Rajiv Chowdhury, Hedyeh Ebrahimi, Yoshihiro Kokubo, Belinda K Lloyd, Samir Bhatt, Geoffrey Buckle, Tissa Wijeratne, Giuseppe Remuzzi, Robert W Aldridge, Luca Ronfani, Raj Kumar Verma, Jagdish Khubchandani, Irma Khonelidze, Ai Koyanagi, Teshome Gebre, Michael Kutz, Om Prakash Singh, Ana Maria Nogales Vasconcelos, Margaret Lind, Svetlana Popova, Hmwe H Kyu, Tom Achoki, Laith J. Abu-Raddad, Zacharie Tsala Dimbuene, Henock Yebyo, Mehdi Yaseri, Max Petzold, Sungho Won, Semaw Ferede Abera, Devina Nand, Rafael Tabarés-Seisdedos, Abdishakur M. Abdulle, Yingfeng Zheng, Soewarta Kosen, Aleksandra Barac, Mahboubeh Parsaeian, Yuichiro Yano, Charles D.A. Wolfe, Simon I. Hay, Luke D. Knibbs, Balem Demtsu Betsu, Solomon Abrha Damtew, Ileana Heredia-Pi, Boris Bikbov, Bemnet Amare Tedla, Daniel Kim, Ulrich O Mueller, Khurshid Alam, Andrew H. Kemp, Austin Carter, Chuanhua Yu, Ibrahim A Khalil, João Mário Pedro, Atsushi Goto, Arsène Kouablan Adou, Scott B. Patten, Nicola Low, Julio Cesar Montañez Hernandez, Heidi J. Larson, Worku Tefera, Sanjay Zodpey, Kalpana Balakrishnan, Hsing-Yi Chang, Jacqueline Castillo Rivas, Donal Bisanzio, Hilda L Harb, Meghan D. Mooney, John N Newton, Vasiliy Victorovich Vlassov, Marcella Montico, Mojde Mirarefin, Vinay Nangia, Edgar P. Simard, Ben Schöttker, Michael Brainin, Ziad A. Memish, Rafael Lozano, Damian G Hoy, Gebre Yitayih Abyu, Alexis J Handal, Saleem M Rana, Francesco Saverio Violante, Monika Sawhney, Eyal Oren, Iqbal R. F. Elyazar, Oluremi N Ajala, Christopher J L Murray, Chioma Ezinne Chibueze, Rupert R A Bourne, Euripide Frinel G Arthur Avokpaho, Andreas A Kudom, Hilton Lam, Aman Yesuf Endries, Farshad Pourmalek, Andre Pascal Kengne, Gholamreza Roshandel, Chandrashekhar T Sreeramareddy, Bolajoko O. Olusanya, Tommi Vasankari, Zahid A Butt, Alemseged Aregay Gebru, Samer Hamidi, Soraya Seedat, Xie Rachel Kulikoff, Maziar Moradi-Lakeh, Gelin Xu, Shireen Sindi, Ruoyan Tobe-Gai, Haidong Wang, Johanna M. Geleijnse, Rajesh Kumar Rai, Ryan M Barber, André Karch, Ione Jayce Ceola Schneider, Hebe N. Gouda, Sibhatu Biadgilign, Erika Ota, Kerrie E. Doyle, Olalekan A. Uthman, Jed D. Blore, Walid Ammar, Guohong Jiang, Carlos A Castañeda-Orjuela, Ibrahim Abubakar, Konstantinos Stroumpoulis, Megan Coggeshall, Charles N Mock, Ronan A Lyons, Jose Martinez-Raga, Thomas Fürst, Ambuj Roy, Mustafa Z. Younis, Harish Chander Gugnani, Mohammad Hifz Ur Rahman, Lidia Morawska, Noore Alam, Paul S. F. Yip, Grant Nguyen, Randah R. Hamadeh, Victor Aboyans, Miloje Savic, Ketevan Gambashidze, Graeme J. Hankey, David M. Pereira, Cho-il Kim, Peter A. Meaney, Haidong Kan, Sameer Vali Gopalani, Murugesan Raju, Saeid Shahraz, Ibrahim Abdelmageem Mohamed Ginawi, Kenji Shibuya, Raimundas Lunevicius, Sun Ha Jee, Prashant Singh, Atte Meretoja, Suzanne Polinder, Alex Reynolds, Joseph Mikesell, David O. Carpenter, Carla Sofia e Sa Farinha, Miguel Angel Alegretti, Nataliya Foigt, Naris Silpakit, Amare Deribew, Gessessew Bugssa Hailu, Mohammed Magdy Abd El Razek, Reza Assadi, Yichong Li, Georgina A. V. Murphy, Babak Eshrati, Rintaro Mori, Scott Weichenthal, Andre Keren, Van C. Lansingh, Kebede Deribe, Bulat Idrisov, François Alla, Maaya Kita, Ala'a Alkerwi, Maia Kereselidze, Yanping Wang, Rajesh Sharma, Florian Fischer, Foluke Adetola Ojelabi, Maya S Fraser, Kingsley N. Ukwaja, H. Dean Hosgood, Puja Rao, Deena Alasfoor, Muhammad Muhammad Saleh, Bryan L. Sykes, Juan Sanabria, Ronny Westerman, Julian David Pillay, Cassandra Szoeke, Umar Bacha, Edward J Mills, Manisha Dubey, Aliya Naheed, Al Artaman, Jiabin Shen, Michael Burch, Reza Malekzadeh, Hans W. Hoek, David C. Schwebel, Alireza Esteghamati, Seok Jun Yoon, Leilei Duan, Matthew M Coates, Arnav Agarwal, Soumya Swaminathan, Quyen Nguyen, Hye-Youn Park, Peter Nguhiu, Bereket Yakob, Patrick Liu, Elisabeth Barboza França, Tigist Assefa Bayou, Azmeraw T. Amare, Farshad Farzadfar, Tariku Jibat, Jost B. Jonas, Kaja Abbas, Thomas Truelsen, Maryam S. Farvid, Louisa Degenhardt, George A. Mensah, Till Bärnighausen, Ivy Shuie, Jee-Young Jasmine Choi, Amitava Banerjee, Zubair Kabir, Ingrid Wolfe, Patrick Martial Nkamedjie Pete, Preet K Dhillon, Kathryn H. Jacobsen, Sadaf G. Sepanlou, Gagandeep Kang, Aminu K. Bello, Bineyam Taye, Mohsen Naghavi, Chhabi Lal Ranabhat, Walter Mendoza, M. Patrice Lindsay, Sergey K Vladimirov, Tesfaye Setegn, Angel J Paternina Caicedo, Eric L. Ding, Narayanaswamy Venketasubramanian, Stephen S Lim, Barthelemy Kuate Defo, Alan D. Lopez, G Anil Kumar, João C. Fernandes, In-Hwan Oh, Rasmus Havmoeller, Amanuel Alemu Abajobir, Pengpeng Ye, Gabrielle deVeber, Espen Bjertness, Hao Zhang, Ali H. Mokdad, Yogeshwar Kalkonde, Peter Memiah, Rodrigo Sarmiento-Suarez, Konrad Pesudovs, Yong Zhao, Joseph Friedman, Abdullah Sulieman Terkawi, Hadi Danawi, André Faro, Kevin N. Sheth, Abera Kenay Tura, Sajjad Ur Rahman, Sergey Soshnikov, Ajit Kumar Yadav, Michelle L. Bell, Nelson Alvis-Guzman, Miia Kivipelto, Pieter de Jager, Yongmei Li, Giancarlo Logroscino, Sivadasanpillai Harikrishnan, Talha Farid, Zewdie Aderaw Alemu, Alemayehu Amberbir, Niveen M E Abu-Rmeileh, Beatriz Paulina Ayala Quintanilla, Parvaiz A Koul, Edson Serván-Mori, Anil Kaul, Cheng Huang, Kalkidan Hassen Abate, Hsiang Huang, Foad Abd-Allah, Marek Majdan, Sait Mentes Birlik, Jung-Chen Chang, Rahul Gupta, Luciano A. Sposato, Sergey Petrovich Ermakov, Ejaz Ahmad Khan, Yibeltal Tebekaw Bayou, Christian Lycke Ellingsen, Ole Frithjof Norheim, Zulfiqar A Bhutta, Hajo Zeeb, Norberto Perico, Jun Zhu, Bruno F. Sunguya, Parthasarathi Ganguly, Fisaha Haile Tesfay, Min-Jeong Shin, Ashish Awasthi, Felix Akpojene Ogbo, Alan J Thomson, Mostafa Qorbani, Ye Jin, Don C. Des Jarlais, Itamar S. Santos, Juanita A. Haagsma, Anwar Rafay, Jacob Olusegun Olusanya, José Neves, Gregory M Anderson, Amador Goodridge, Bolanle F Banigbe, David Rojas-Rueda, Pedro R. Olivares, Rakhi Dandona, Stefanos Tyrovolas, Peter Njenga Keiyoro, Stein Emil Vollset, Andrea Werdecker, Mohamed Hsairi, Chandrasekharan Nair Kesavachandran, Jeanne Françoise Kayibanda, Alemayehu B. Mekonnen, Addisu Shunu Beyene, Lela Sturua, Inga Dora Sigfusdottir, Amber Sligar, Maysaa El Sayed Zaki, Shiwei Liu, Melkamu Dedefo Gishu, Chantal Huynh, Lope H Barrero, Linhong Wang, Neeraj Bedi, Masood Ali Shaikh, Ricky Leung, Mehdi Javanbakht, Alemayehu Hailu, Kimani M Harun, Ubai Alsharif, Richard C. Franklin, Zoubida Zaidi, Hassan Magdy Abd El Razek, Masako Horino, Karzan Abdulmuhsin Mohammad, Diego Augusto Santos Silva, Marcello Tonelli, Juan Jesus Carrero, Cyrus Cooper, Rajaa Al-Raddadi, Juan Liang, Leslie Cornaby, Awoke Misganaw, Norito Kawakami, Carl Abelardo T. Antonio, Daniel J. Weiss, Abhishek Singh, Vivekanand Jha, Seyed-Mohammad Fereshtehnejad, Serge Resnikoff, Gizachew Assefa Tessema, Alem Mehari, Wagner Marcenes, Chabila C Mapoma, Ababi Zergaw Giref, Farhad Pishgar, Khassoum Diallo, Nicholas J K Breitborde, Emmanuel A. Ameh, Justin Beardsley, Ademola Lukman Adelekan, Joshua A. Salomon, Mamo Wubshet, Diego De Leo, Daniel Pope, Elisabete Weiderpass, Gregory A. Roth, Niranjan Kissoon, Kaire Innos, João Vasco Santos, Rajesh Sagar, Bradford D. Gessner, Akindele Olupelumi Adebiyi, John J Huang, Dharmesh Kumar Lal, Samantha M. Colquhoun, Eduardo Bernabé, Nadia Akseer, Maheswar Satpathy, Fotis Topouzis, Health Services Management & Organisation (HSMO), Public Health, Psychiatry, Neurology, Wang, Haidong, Bhutta, Zulfiqar A, Coates, Matthew M, Coggeshall, M, Ciobanu, Liliana G, Murray, Christopher JL, Coggeshall, Megan, Dandona, Lalit, Diallo, Khassoum, Franca, Elisabeth Barboza, Fraser, Maya, Fullman, Nancy, Gething, Peter W, Hay, Simon I, Kinfu, Yohanne, Kita, Maaya, Kulikoff, Xie Rachel, Larson, Heidi J, Liang, Juan, Liang, Xiaofeng, Lind, Margaret, Lopez, Alan D, Lozano, Rafael, Mensah, George A, Mikesell, Joseph B, Mokdad, Ali H, Mooney, Meghan D, Nguyen, Grant, Rakovac, Ivo, Salomon, Joshua A, Silpakit, Nari, Sligar, Amber, Sorensen, Reed J D, Vos, Theo, Zhu, Jun, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbas, Kaja M, Abd-Allah, Foad, Abdulle, Abdishakur M, Abera, Semaw Ferede, Aboyans, Victor, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Abyu, Gebre Yitayih, Achoki, Tom, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adelekan, Ademola Lukman, Adou, Arsène Kouablan, Agarwal, Arnav, Ajala, Oluremi N, Akinyemiju, Tomi F, Akseer, Nadia, Alam, Khurshid, Alam, Noore K M, Alasfoor, Deena, Aldridge, Robert William, Alegretti, Miguel Angel, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'A, Alla, Françoi, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Martin, Elena Alvarez, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amegah, Adeladza Kofi, Ameh, Emmanuel A, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H, Anderson, Gregory M, Antonio, Carl Abelardo T, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Banigbe, Bolanle F, Barac, Aleksandra, Barber, Ryan M, Barker-Collo, Suzanne L, Bärnighausen, Till, Barrero, Lope H, Bayou, Tigist Assefa, Bayou, Yibeltal Tebekaw, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Bhatt, Samir, Biadgilign, Sibhatu, Bikbov, Bori, Birlik, Sait Mente, Bisanzio, Donal, Bjertness, Espen, Blore, Jed D, Bourne, Rupert R A, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brown, Alexandria, Buckle, Geoffrey Colin, Burch, Michael, Butt, Zahid A, Campos-Nonato, Ismael Ricardo, Campuzano, Julio Cesar, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesu, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Rivas, Jacqueline Castillo, Castro, Ruben Estanislao, Catalá-López, Ferrán, Cercy, Kelly, Chang, Hsing-Yi, Chang, Jung-Chen, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christopher, Devasahayam Jesuda, Colquhoun, Samantha M, Cooper, Cyru, Cornaby, Leslie, Damtew, Solomon Abrha, Danawi, Hadi, Dandona, Rakhi, das Neves, José, Davis, Adrian C, de Jager, Pieter, De Leo, Diego, Degenhardt, Louisa, Deribe, Kebede, Deribew, Amare, Jarlais, Don C De, Deveber, Gabrielle A, Dharmaratne, Samath D, Dhillon, Preet K, Ding, Eric L, Doshi, Pratik Pinal, Doyle, Kerrie E, Duan, Leilei, Dubey, Manisha, Ebrahimi, Hedyeh, Ellingsen, Christian Lycke, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Esteghamati, Alireza, Faraon, Emerito Jose Aquino, Farid, Talha A, Farinha, Carla Sofia e Sa, Faro, André, Farvid, Maryam S, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fernandes, Joao C, Fischer, Florian, Fitchett, Joseph R A, Foigt, Nataliya, Franklin, Richard C, Friedman, Joseph, Fürst, Thoma, Gambashidze, Ketevan, Gamkrelidze, Amiran, Ganguly, Parthasarathi, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Gebru, Alemseged Aregay, Geleijnse, Johanna M, Gessner, Bradford D, Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Gishu, Melkamu Dedefo, Gomez-Dantes, Hector, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Goto, Atsushi, Gouda, Hebe N, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gyawali, Bishal, Haagsma, Juanita A, Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Harb, Hilda L, Harikrishnan, Sivadasanpillai, Harun, Kimani M, Havmoeller, Rasmu, Hay, Roderick J, Heredia-Pi, Ileana Beatriz, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hotez, Peter J, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Huang, Cheng, Huang, John J, Huang, Hsiang, Huiart, Laetitia, Iburg, Kim Moesgaard, Idrisov, Bulat T, Innos, Kaire, Jacobsen, Kathryn H, Jahanmehr, Nader, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jibat, Tariku, Jin, Ye, Jonas, Jost B, Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Kang, Gagandeep, Karch, André, Karema, Corine Kakizi, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kayibanda, Jeanne Françoise, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khalil, Ibrahim A, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khang, Young-Ho, Khonelidze, Irma, Khubchandani, Jagdish, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D, Kokubo, Yoshihiro, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A, Kumar, G Anil, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lam, Hilton, Lam, Jennifer O, Lansingh, Van C, Larsson, Ander, Leigh, Jame, Leung, Ricky, Li, Yichong, Li, Yongmei, Lindsay, M Patrice, Liu, Patrick Y, Liu, Shiwei, Lloyd, Belinda K, Lo, Warren D, Logroscino, Giancarlo, Low, Nicola, Lunevicius, Raimunda, Lyons, Ronan A, Ma, Stefan, Razek, Hassan Magdy Abd El, Razek, Mohammed Magdy Abd El, Mahdavi, Mahdi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Mapoma, Chabila C, Marcenes, Wagner, Martinez-Raga, Jose, Marzan, Melvin Barriento, Masiye, Felix, Mcgrath, John J, Meaney, Peter A, Mehari, Alem, Mehndiratta, Man Mohan, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J, Mhimbira, Francis Apolinary, Miller, Ted R, Mills, Edward J, Mirarefin, Mojde, Misganaw, Awoke, Mock, Charles N, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Hernandez, Julio Cesar Montañez, Montico, Marcella, Moore, Ami R, Moradi-Lakeh, Maziar, Morawska, Lidia, Mori, Rintaro, Mueller, Ulrich O, Murphy, Georgina A V, Murthy, Sriniva, Nachega, Jean B, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Neupane, Suba, Newton, Charles R, Newton, John N, Ng, Marie, Ngalesoni, Frida Namnyak, Nguhiu, Peter, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Norheim, Ole F, Norman, Rosana E, Ogbo, Felix Akpojene, Oh, In-Hwan, Ojelabi, Foluke Adetola, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oren, Eyal, Ota, Erika, Pa, Mahesh, Park, Eun-Kee, Park, Hye-Youn, Parsaeian, Mahboubeh, Caicedo, Angel J Paternina, Patten, Scott B, Pedro, João Mário, Pereira, David M, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Pillay, Julian David, Pishgar, Farhad, Polinder, Suzanne, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Qorbani, Mostafa, Rabiee, Rynaz H S, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Raju, Murugesan, Ram, Usha, Rana, Saleem M, Ranabhat, Chhabi Lal, Rao, Puja, Refaat, Amany H, Remuzzi, Giuseppe, Resnikoff, Serge, Reynolds, Alex, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Roy, Ambuj, Ruhago, George Mugambage, Sagar, Rajesh, Saleh, Muhammad Muhammad, Sanabria, Juan R, Sanchez-Niño, Maria Dolore, Santos, Itamar S, Santos, João Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Setegn, Tesfaye, Shahraz, Saeid, Shaikh, Masood Ali, Shakh-Nazarova, Marina, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Sheth, Kevin N, Shibuya, Kenji, Shin, Hwashin Hyun, Shin, Min-Jeong, Shiri, Rahman, Shuie, Ivy, Sigfusdottir, Inga Dora, Silva, Diego Augusto Santo, Silverberg, Jonathan, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Singh, Virendra, Soriano, Joan B, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Steel, Nichola, Stroumpoulis, Konstantino, Sturua, Lela, Sunguya, Bruno F, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Tavakkoli, Mohammad, Taye, Bineyam, Tedla, Bemnet Amare, Tefera, Worku Mekonnen, Tekle, Tesfaye, Shifa, Girma Temam, Terkawi, Abdullah Sulieman, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Thapa, Kiran, Thomson, Alan J, Thorne-Lyman, Andrew L, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thoma, Dimbuene, Zacharie Tsala, Tura, Abera Kenay, Tyrovolas, Stefano, Ukwaja, Kingsley N, Uneke, Chigozie Jesse, Uthman, Olalekan A, Vaezghasemi, Masoud, Vasankari, Tommi, Vasconcelos, Ana Maria Nogale, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wang, Linhong, Wang, Yanping, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Widdowson, Marc-Alain, Wijeratne, Tissa, Williams, Thomas Neil, Wiysonge, Charles Shey, Wolfe, Charles D A, Wolfe, Ingrid, Won, Sungho, Wubshet, Mamo, Xiao, Qingyang, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhang, Hao, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zodpey, Sanjay, and Murray, Christopher J L
Subjects: Pediatrics, Nutrition and Disease, Global Health, Communicable Disease, 0302 clinical medicine, Voeding en Ziekte, Infant Mortality, Compensation law of mortality, Global health, Medicine, LIFE EXPECTANCY, 030212 general & internal medicine, DEVELOPING-COUNTRIES, 10. No inequality, Medicine(all), NEWBORN BABIES, Medicine (all), Mortality rate, 1. No poverty, DEATH, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, 11 Medical And Health Sciences, Stillbirth, 3. Good health, Child Mortality, SURVIVAL, CHILD-MORTALITY, HEALTH, Life Sciences & Biomedicine, DEVELOPMENT GOAL 4, Human, INTERVENTIONS, medicine.medical_specialty, RJ, INTEGRATED APPROACH, Developing country, Communicable Diseases, neonatal, 03 medical and health sciences, Medicine, General & Internal, 030225 pediatrics, General & Internal Medicine, Life Science, Humans, Global Burden of Disease Study, VLAG, Estimation, Science & Technology, business.industry, Klinisk medicin, Infant, GBD 2015 Child Mortality Collaborators, Infant mortality, Malaria, Child mortality, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Life expectancy, Clinical Medicine, RG, business, Demography
Abstract: BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. METHODS: Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1-4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980-2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age-sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). FINDINGS: Globally, 5·8 million (95% uncertainty interval [UI] 5·7-6·0) children younger than 5 years died in 2015, representing a 52·0% (95% UI 50·7-53·3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42·4% (41·3-43·6) to 2·6 million (2·6-2·7) neonatal deaths and 47·0% (35·1-57·0) to 2·1 million (1·8-2·5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3·0% (2·6-3·3), falling short of the 4·4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4·4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10·3 million fewer under-5 deaths than expected on the basis of improving SDI alone. INTERPRETATION: Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030. FUNDING: Bill & Melinda Gates Foundation. Erratum: Department of Error, The Lancet,Volume 389, Issue 10064, 2017, Page e1. DOI: 10.1016/S0140-6736(16)32608-3
Published: 2016

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15 results on '"Razek, Mohammed"'

1. Effect of Change in Newborn’s Position during Mechanical Ventilation on Oxygenation

2. Burden of lower respiratory infections in the Eastern Mediterranean Region between 1990 and 2015: findings from the Global Burden of Disease 2015 study

3. Burden of vision loss in the Eastern Mediterranean region, 1990–2015: findings from the Global Burden of Disease 2015 study

4. Prospective study of nephrolithiasis occurrence in children receiving cefotriaxone

5. Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

6. Intentional injuries in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

7. Burden of diarrhea in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

8. Transport injuries and deaths in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 Study

9. Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study

10. Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

11. Maternal mortality and morbidity burden in the Eastern Mediterranean Region : findings from the Global Burden of Disease 2015 study

12. The burden of mental disorders in the Eastern Mediterranean region, 1990-2015 : findings from the global burden of disease 2015 study

13. Danger ahead: the burden of diseases, injuries, and risk factors in the Eastern Mediterranean Region, 1990–2015

14. International Journal of Public Health

15. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015 : a systematic analysis for the Global Burden of Disease Study 2015

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15 results on '"Razek, Mohammed"'

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