1. Senescent mesenchymal stem/stromal cells and restoring their cellular functions
- Author
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Xiaohui Zhou, Lu Wei, Xiaoting Liang, Huimin Fan, Jing Liu, and Qingshu Meng
- Subjects
0301 basic medicine ,Senescence ,Histology ,Stromal cell ,Cell ,Cellular functions ,Economic shortage ,Review ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,Function ,Molecular Biology ,Genetics (clinical) ,Features ,Rejuvenation strategy ,Mesenchymal stem cell ,Cell Biology ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Mesenchymal stem cells ,Stem cell ,Function (biology) - Abstract
Mesenchymal stem/stromal cells (MSCs) have various properties that make them promising candidates for stem cell-based therapies in clinical settings. These include self-renewal, multilineage differentiation, and immunoregulation. However, recent studies have confirmed that aging is a vital factor that limits their function and therapeutic properties as standardized clinical products. Understanding the features of senescence and exploration of cell rejuvenation methods are necessary to develop effective strategies that can overcome the shortage and instability of MSCs. This review will summarize the current knowledge on characteristics and functional changes of aged MSCs. Additionally, it will highlight cell rejuvenation strategies such as molecular regulation, non-coding RNA modifications, and microenvironment controls that may enhance the therapeutic potential of MSCs in clinical settings.
- Published
- 2020