1. CHOROIDAL VASCULARITY INDEX QUANTIFICATION IN GEOGRAPHIC ATROPHY USING BINARIZATION OF ENHANCED-DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHIC SCANS
- Author
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Stefano Sebastiani, Claudio Iovino, Giuseppe Giannaccare, Fabiana Moscardelli, Federico Bernabei, Emilio C. Campos, Pietro Emanuele Napoli, Marco Pellegrini, Giannaccare, G., Pellegrini, M., Sebastiani, S., Bernabei, F., Moscardelli, F., Iovino, C., Napoli, P. E., Campos, E., Giannaccare, Giuseppe, Pellegrini, Marco, Sebastiani, Stefano, Bernabei, Federico, Moscardelli, Fabiana, Iovino, Claudio, Napoli, Pietro E, and Campos, Emilio
- Subjects
Male ,Visual acuity ,NO ,03 medical and health sciences ,0302 clinical medicine ,Vascularity ,Optical coherence tomography ,Retrospective Studie ,Geographic Atrophy ,0502 economics and business ,Humans ,Medicine ,age-related macular degeneration ,Retrospective Studies ,Aged ,choroidal vascularity index, CVI, geographic atrophy, OCT ,optical coherence tomography ,medicine.diagnostic_test ,Choroid ,business.industry ,05 social sciences ,Retinal Vessels ,General Medicine ,choroidal vascularity index ,Macular degeneration ,Control subjects ,medicine.disease ,Retinal Vessel ,age-related macular degeneration, geographic atrophy, choroidal vascularity index, optical coherence tomography ,Geographic atrophy ,Ophthalmology ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,Female ,050211 marketing ,sense organs ,Enhanced depth imaging ,medicine.symptom ,business ,Nuclear medicine ,Tomography, Optical Coherence ,Human - Abstract
Purpose: To evaluate choroidal structural changes occurring over time in geographic atrophy (GA) secondary to age-related macular degeneration using choroidal vascularity index (CVI). Methods: Enhanced-depth imaging optical coherence tomography scans of 34 patients with GA and 32 control subjects were retrospectively analyzed. Data were collected at baseline and after a mean follow-up of 18.3 ± 8.3 months. Choroidal images were binarized using the ImageJ software, and the luminal area and stromal area were segmented. Cho- roidal vascularity index was defined as the ratio of luminal area to total choroid area. Results: Patients with GA showed significantly lower values of CVI, total choroid area, luminal area, and subfoveal choroidal thickness compared to control subjects (65.83 ± 3.95 vs. 69.33 ± 3.11, P , 0.001; 0.400 ± 0.239 mm2 vs. 0.491 ± 0.132, P = 0.006; 0.263 ± 0.152 mm2 vs. 0.340 ± 0.094, P = 0.002; 185.2 ± 79.8 mm vs. 216.8 ± 58.8 mm, P = 0.036, respectively). Best-corrected visual acuity was significantly correlated only with choroidal thickness (R = 20.509; P = 0.002). During the follow-up period in patients with GA, sub- foveal choroidal thickness decreased from 185.2 ± 79.8 to 152.2 ± 73.1 (P = 0.001), stromal area increased from 0.138 ± 0.090 mm2 to 0.156 ± 0.068 (P = 0.028), and CVI decreased from 65.83 ± 3.95 to 62.24 ± 3.63 (P , 0.001). Conclusion: This study showed for the first time that CVI is reduced in patients with GA, and that this metric further worsened during the follow-up period.
- Published
- 2020