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Your search keyword '"Marcos Guzmán García"' showing total 3 results
Start Over Author "Marcos Guzmán García" Topic 0302 clinical medicine
3 results on '"Marcos Guzmán García"'

1. Palliative Sedation in Patients Hospitalized in Internal Medicine Departments

Author

Jesús Díez-Manglano, Soledad Isasi de Isasmendi Pérez, Rosa García Fenoll, Luis Ángel Sánchez, Françesc Formiga, Vicente Giner Galvañ, Carlos Dueñas, Bernardino Roca, Cristina Estrada Díaz, Emilio Casariego Vales, Marta Rubio Gómez, Magdalena Martín Pérez, Luis Felipe Díez García, Ignacio Vallejo Maroto, Cristina Ocaña Losada, Susana Moya Roldán, Catalina Díaz Pérez, Javier Caballero Granado, Resfa María García Font, Francisco J. Jódar Lorente, Gloria Pérez Vázquez, Ana belén Ferro Expósito, María Luisa Amaya González, Fernando Gamboa Antiñolo, Álvaro González Molina, Mercedes Gómez Hernández, Marcos Guzmán García, Lola Benítez León, Lorena Montero Rivas, María Ruiz Mariscal, Noelia Gómez Aguirre, María Pilar González García, Isabel Martín Algora, María Carmen Bueno Castel, Fernando Ruiz Laiglesia, Esperanza Bejarano Tello, José Luis Cabrerizo García, Nuria Guiral Fernández, Luis Camera, Carla Gauna, Pedro Abad Requejo, Rocío Martínez Gutiérrez, Rebeca Fernández Regueiro, María Teresa Sánchez Vidal, Joaquín Alfonso Mejido, Enrique García Carús, Carmen Elena Calvo Rodríguez, Paula Martínez García, Sixto Ruiz Olivares, María Isabel Fullana Barcelo, Carmen González Arencibia, Rosa Ros Vilamajó, María José Monedero Prieto, Concepción González Becerra, Sofía Pérez, Andrea Martín Plata, Raquel Portilla Chocarro, Carlos Dueñas Gutiérrez, Francisco Estrada Álvarez, Sonia Peña Balbuena, Raúl Rodríguez Galindo, Marta María Cobos Siles, Luis Ángel Sánchez Muñoz, Ana Castañón López, Celia Sanz Lobo, María Montserrat Chimeno Viñas, María Ángeles Contreras Uriel, Judit Gil Domínguez, Francisco Medrano González, José Manuel Machín Lázaro, Jeffrey Magallanes Gamboa, Mónica Rodríguez Galdeano, Joaquín Castro Giménez, José Ramón Barberá Farré, Raquel Núñez Aragón, Ferrán Masanés Torán, José Barbé, Elena Güell Farré, Olga Torres Bonafonte, Ana lozano Miñana, Desirée Moras Sarabia, Rosa Pérez, Dolors Arnau i Fernández, Francesc Formiga, Javier Fernández Fernández, Antoni Castro Salomó, Rami Qanneta, María Victoria Pardo Ortega, Yasmina Monterroso Pintado, Montserrat García Cors, María Cruz Almendros Rivas, Dolors Domingo Albin, Jaume Roig Morera, Nuria Galofré Álvaro, Aythami Toro Parodi, Mario Loureiro Sánchez, Carla de la Guerra Acebal, Javier Zubizarreta García, Iasone Benavente Claveras, Juan Martí Cabanes, Ignacio Sanz Lázaro, José Barquero Romero, Leticia Nevado López-Alegría, José Carlos Arévalo Lorido, Ana María Lorenzo Vizcaya, Cristina Macía Rodríguez, Silvia Pérez Fernández, Pascual Sesma Sánchez, María Dolores Jiménez-Beatty, Laura González Vázquez, Ángel Brea Hernando, Jesús Castiella Herrero, María Isabel González Anglada, Virginia M. Gracia Lorenzo, Alejandro Pérez Martín, Gerardo García Melcón, María Gómez Antúnez, María Angustias Quesada Simón, Fuensanta Gil Gil, María Asenjo Martínez, Lourdes Mancebo Aragoneses, Jorge Calderón Parra, María del Carmen Romero Pérez, José Curbelo García, Fernando Laguna Cuesta, María Eugenia Segovia Abad, María Fontecha Ortega, Guillermina Lara Martínez, Ana Pinos Blanco, Raquel Rodil Fraile, Elisabel Martínez Litago, Aitziber Echeverría Echeverría, Manuel Priego Valladares, Carlos Trescoli Serrano, Josep Vicente Mas, Óscar Torregrosa Suau, Eva Gil Tomás, Rafael Castillo Rubio, José Manuel Murcia Zaragoza, Pilar Román Sánchez, Ana García Herola, Pedro Pablo Tenllado Doblas, Julio César Blázquez Encinar, Enrique Castellano Vela, Néstor Carrizo, Bernardino Manuel Roca Villanueva, Francisco Pasquau Liaño, and José María Pascual Izuel

Subjects
Clinical audit, medicine.medical_specialty, Palliative care, Argentina, Context (language use), Palliative sedation, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Terminal care, Humans, Hypnotics and Sedatives, Medicine, In patient, 030212 general & internal medicine, General Nursing, Retrospective Studies, Terminal Care, business.industry, Palliative Care, Odds ratio, Cross-Sectional Studies, Anesthesiology and Pain Medicine, Spain, 030220 oncology & carcinogenesis, Observational study, Neurology (clinical), business
Abstract

Palliative sedation is used to relieve end-of-life refractory symptoms.The objective of this study was to describe the use of palliative sedation in patients who die in internal medicine departments.An observational, cross-sectional, retrospective, and multicenter clinical audit study was conducted in 145 hospitals in Spain and Argentina. Each hospital included the first 10 patients who died in the internal medicine department, starting on December 1, 2015.We included 1447 patients, and palliative sedation was administered to 701 patients (48.4%). Having a terminal illness (odds ratio [OR] 2.469, 95% CI 1.971-3.093, P 0.001) and the length of hospital stay (OR 1.011, 95% CI 1.002-1.021, P = 0.017) were independently associated with the use of palliative sedation. Consent was granted by the families of 582 (83%) patients. The most common refractory symptom was dyspnea, and the most commonly used drugs for sedation were midazolam (77%) and morphine (89.7%). An induction dose was administered in 25.7% of the patients. Rescue doses were scheduled for 70% of the patients, and hydration was maintained in 49.5%. Pain was more common in patients with cancer, whereas dyspnea was more common in those without cancer. Rescue doses were used more often for the patients with cancer (77.8% vs. 67.7%, P = 0.015). Monitoring the palliative sedation with a scale was more frequent in the patients with cancer (23.7% vs. 14.3%, P = 0.008).Palliative sedation is used more often for terminal patients. There are differences in the administration of palliative sedation between patients with and without cancer.

Published
2020
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2. Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19

Author

Andrea Mendizabal, Marcos Guzmán-García, Elisa Rabadán-Pejenaute, Jose D Torres-Peña, Marta Nataya Solís-Marquínez, María Dolores Martín-Escalante, Araceli Pineda-Cantero, Maria Del Pilar Fidalgo-Montero, Francisco Javier Carrasco-Sánchez, Enrique Rodilla, Joaquín Fernandez López-Cuervo, María Esther Guisado-Espartero, Ricardo Gil-Sánchez, Lucy Abella-Vázquez, Ángel Luis Martínez-González, Ricardo Gómez-Huelgas, José Manuel Casas-Rojo, Elizabeth Lorenzo-Hernández, Joaquín Escobar-Sevilla, Julio González-Moraleja, Andrés de la Peña-Fernández, Vicente Giner-Galvañ, Alberto Saura, Ramon Boixeda, Iratxe Jimenez, UCH. Departamento de Medicina y Cirugía, Producción Científica UCH 2020, [Rodilla,E, Saura,A, Jiménez,I, Mendizábal,A] Internal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, Sagunto, Spain. [Pineda-Cantero,A, Lorenzo-Hernández,E, and Gómez-Huelgas,R] Internal Medicine Department, Regional University Hospital of Málaga, Málaga, Spain. [Fidalgo-Montero,MP] Internal Medicine Department, Henares Hospital, Coslada (Madrid), Spain. [Fernandez López-Cuervo,J] Internal Medicine Department, Torrevieja University Hospital, Torrevieja (Alicante), Spain. [Gil-Sánchez,R] Internal Medicine Department, La Fe University Hospital, Valencia, Spain. [Rabadán-Pejenaute,E] Internal Medicine Department, San Pedro Hospital, Logroño (La Rioja), Spain. [Abella-Vázquez,L] Internal Medicine Department, Ntra Sra Candelaria University Hospital, Santa Cruz de Tenerife, Spain. [Giner-Galvañ,V] Internal Medicine Department, Hypertension and Cardiometabolic Risk Unit, San Juan de Alicante University Hospital, Miguel Hernández University, San Juan de Alicante (Alicante), Spain. [Solís-Marquínez,MN] Internal Medicine Department, San Agustin University Hospital, Avilés (Asturias), Spain. [Boixeda,R] Internal Medicine Department, Mataró Hospital, Mataró, Barcelona, Spain. [de la Peña-Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Carrasco-Sánchez,FJ] Internal Medicine Department, Juan Ramón Jiménez Hospital, Huelva, Spain. [González-Moraleja,J] Internal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain. [Torres-Peña,JD] Internal Medicine Department, Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain. [Guisado-Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra (Córdoba), Spain. [Escobar-Sevilla,J] Internal Medicine Department, Virgen de las Nieves University Hospital, Granada, Spain. [Guzmán-García,M] Internal Medicine Department, San Juan de la Cruz Hospital, Úbeda (Jaén), Spain. [Martín-Escalante,MD] Internal Medicine Department, Costa del Sol Hospital, Marbella (Málaga), Spain. [Martínez-González,AL] Internal Medicine Department, León University Hospital Complex, León, Spain. [Casas-Rojo,JM] Internal Medicine Department, Infanta Cristina University Hospital, Parla (Madrid), Spain.

Subjects
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Cardiovascular Agents::Antihypertensive Agents [Medical Subject Headings], Hipertensión, Multivariate analysis, Physiology, lcsh:Medicine, Disease, 030204 cardiovascular system & hematology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, SARS-CoV-2 (Virus) - Pacientes - Mortalidad, 030212 general & internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Vital Statistics::Mortality [Medical Subject Headings], Atrial fibrillation, General Medicine, Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [Medical Subject Headings], humanities, Population study, all-cause mortality, Inhibidores de la enzima convertidora de angiotensina, Cardiology and Cardiovascular Medicine, angiotensin-converting enzyme inhibitors (ACEIs), medicine.medical_specialty, angiotensin II receptor blockers (ARBs), hypertension, Infecciones por coronavirus, Antagonistas de receptores de angiotensina, COVID-19 (Disease) - Patients - Mortality, Lower risk, Article, Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings], 03 medical and health sciences, Internal medicine, Diabetes mellitus, Hypertension, Internal Medicine, medicine, Risk factor, COVID-19, all-cause mortality, angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs), hypertension, COVID-19 - Pacientes - Mortalidad, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, lcsh:R, COVID-19, medicine.disease, Comorbidity, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], SARS-CoV-2 (Virus) - Patients - Mortality, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings], Observational study, business, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors::Angiotensin-Converting Enzyme Inhibitors [Medical Subject Headings]
Abstract

It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 &plusmn, 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.

Published
2020

3. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

Author

Carmen Herrero Rodríguez, Clara Natera Kindelán, Teresa Marrodan Ciordia, Marcos Guzmán García, Juan Sevilla Blanco, Lucía Boix-Palop, Carlos Armiñanzas Castillo, Adrian Sousa Domínguez, Luis Eduardo López-Cortés, Alfredo Jover Saenz, Alberto Bahamonde-Carrasco, María Ángeles Mantecon Vallejo, Isabel María Reche Molina, María Luisa Cantón-Bulnes, José María Reguera-Iglesias, Eva León Jiménez, Berta Becerril Carral, Inmaculada López-Hernández, Jesús Rodríguez-Baño, Alfonso Del Arco Jiménez, José Bravo-Ferrer, Joaquín Felipe Lanz-García, Esperanza Merino de Lucas, Antonio Sánchez-Porto, Josune Goikoetxea Aguirre, David Garcia, Inés Pérez Camacho, Fátima Galán-Sánchez, Jonathan Fernández Suárez, Pedro María Martínez Pérez-Crespo, Alejandro Smithson Amat, Jordi Cuquet Pedragosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, and European Commission

Subjects
Adult, Male, 0301 basic medicine, Microbiology (medical), Staphylococcus aureus, medicine.medical_specialty, Multivariate analysis, Adolescent, Epidemiology, 030106 microbiology, Bacteremia, Bloodstream infection, Healthcare-associated, Logistic regression, Severity of Illness Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Interquartile range, Klebsiella, Internal medicine, Escherichia coli, medicine, Humans, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Aetiology, Prospective cohort study, Aged, Aged, 80 and over, Cross Infection, business.industry, Mortality rate, General Medicine, Middle Aged, Confidence interval, Community-Acquired Infections, Infectious Diseases, Spain, Etiology, Bacteraemia, Female, business
Abstract

PROBAC REIPI/GEIH-SEIMC/SAEI Group., The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition., This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020.

Published
2021
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