1. HTLV-I induces lesions in the pulmonary system: A systematic review
- Author
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Luiz Euclides Coelho de Souza Filho Me, Ápio Ricardo Nazareth Dias Me., Marcio Clementino de Souza Santos, Juarez Antônio Simões Quaresma, Regis Bruni Andriolo, André Luiz Saldanha Eremita da Silva Lic., Valéria Marques Ferreira Normando, Rita Catarina Medeiros Sousa, Luiz Fábio Magno Falcão, Denise da Silva Pinto, Waldônio de Brito Vieira Esp, Caroline Lobato Rodrigues Lic, and Ediléa Monteiro de Oliveira
- Subjects
0301 basic medicine ,Lung Diseases ,medicine.medical_specialty ,Population ,V?rus Linfotr?pico T Tipo 1 Humano / isolamento & purifica??o ,030226 pharmacology & pharmacy ,General Biochemistry, Genetics and Molecular Biology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Revis?es Sistem?ticas como Assunto ,Internal medicine ,medicine ,Animals ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,education ,Respiratory Tract Infections ,education.field_of_study ,Human T-lymphotropic virus 1 ,Bronchiectasis ,business.industry ,Case-control study ,General Medicine ,medicine.disease ,HTLV-I Infections ,Doen?as Respirat?rias / diagn?stico por imagem ,Infec??es por HTLV-I ,030104 developmental biology ,Systematic review ,Case-Control Studies ,Cohort ,Les?o Pulmonar ,Metan?lise ,Bronchitis ,business ,Kappa ,Cohort study - Abstract
Federal University of Par?. Center for Tropical Medicine. Bel?m, PA, Brazil / State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. Federal University of Par?. Center for Tropical Medicine. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. Federal University of Par?. Center for Tropical Medicine. Bel?m, PA, Brazil / Santa Casa de Miseric?rdia Foundation. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. Federal University of Par?. Center for Tropical Medicine. Bel?m, PA, Brazil. State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil. Federal University of Par?. Center for Tropical Medicine. Bel?m, PA, Brazil / State University of Par?. Center for Biological and Health Sciences. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on language and publication period. The study was registered in the PROSPERO systematic analysis database (Protocol No. CRD42017078236) and was prepared according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The following databases were used: PubMed, BVS Regional Portal, Embase, CINAHL and Web of Science. We utilized the Newcastle-Ottawa Scale to assess the methodological quality of published studies and the Kappa coefficient to assess the agreement level between two reviewers. Of the total 1156 studies retrieved by the search strategy, 28 were considered potentially eligible (Kappa test = 0.928). Of the 28 studies, three fully met the inclusion criteria. These indicated that pulmonary lesions, such as bronchiectasis and bronchitis/bronchiolitis, were observed in patients with HTLV-1, with high-resolution computed tomography of the chest being the main method of diagnostic investigation. The analyzed cohort and case-control studies indicated an etiological relationship between HTLV-1 infection and the presence of lung lesions, with emphasis on bronchiectasis in the presence of high viral loads, as well as a higher mortality in these individuals compared with the general population.
- Published
- 2020