1. Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases
- Author
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Petr Volf, Katerina Pruzinova, Matthew S. Tremblay, Robert W. Sauerwein, Arnab Chatterjee, Angelika Sturm, Baiyuan Yang, Teun Bousema, Neil M. Ferguson, Hans-Peter Duerr, Maarten Eldering, Graham P. Trevitt, John Wisler, Constantianus J. M. Koenraadt, Magdalena Jancarova, Koen J. Dechering, Pauline Ambrose, Rosemary Susan Lees, Hannah C Slater, Peter G. Schultz, Karin M. J. Koolen, Miglianico Marie, Bill & Melinda Gates Foundation, National Institutes of Health, and Medical Research Council (MRC)
- Subjects
0301 basic medicine ,Fluralaner ,Veterinary medicine ,Insecticides ,Mosquito Control ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,chemistry.chemical_compound ,0302 clinical medicine ,Phlebotomus ,Laboratory of Entomology ,Insecticide ,education.field_of_study ,Multidisciplinary ,Anopheles ,PE&RC ,3. Good health ,PNAS Plus ,Culex ,030231 tropical medicine ,Population ,wc_524 ,Mosquito Vectors ,Biology ,Isoxazoline ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,MD Multidisciplinary ,parasitic diseases ,qx_600 ,medicine ,Animals ,Humans ,education ,Aedes ,wa_240 ,Laboratorium voor Entomologie ,medicine.disease ,biology.organism_classification ,Vector control ,Malaria ,wc_750 ,030104 developmental biology ,Culicidae ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,chemistry ,Zika fever ,Vector (epidemiology) ,Communicable Disease Control ,qw_70 ,Psychodidae - Abstract
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Aedes, and Culex mosquitoes and Phlebotomus sand flies after feeding on a drug-supplemented blood meal, with IC50 values ranging from 33 to 575 nM, and were fully active against strains with preexisting resistance to common insecticides. Based on allometric scaling of preclinical pharmacokinetics data, we predict that a single human median dose of 260 mg (IQR, 177-407 mg) for afoxolaner, or 410 mg (IQR, 278-648 mg) for fluralaner, could provide an insecticidal effect lasting 50-90 days against mosquitoes and Phlebotomus sand flies. Computational modeling showed that seasonal mass drug administration of such a single dose to a fraction of a regional population would dramatically reduce clinical cases of Zika and malaria in endemic settings. Isoxazolines therefore represent a promising new component of drug-based vector control.
- Published
- 2018