1. Guarana (Paullinia cupana): Cytoprotective effects on age-related eye dysfunction
- Author
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Margarete Dulce Bagatini, Grazielle Castagna Cezimbra Weis, Marta Maria Medeiros Frescura Duarte, Charles Elias Assmann, Kennya Márcia dos Santos Motta, Cláudio do Carmo Chaves, Francine Carla Cadoná, Ivana Beatrice Mânica da Cruz, Beatriz da Silva Rosa Bonadiman, Euler Esteves Ribeiro, Claudia Maria Chaves, and Audrei de Oliveira Alves
- Subjects
0301 basic medicine ,Eye quality ,medicine.medical_specialty ,Necrosis ,genetic structures ,Medicine (miscellaneous) ,Pharmacology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,food ,Guarana ,Age related ,Medicine ,Paullinia cupana ,TX341-641 ,Nutrition and Dietetics ,business.industry ,Nutrition. Foods and food supply ,Macular degeneration ,Retinal ,Eye disorders ,medicine.disease ,food.food ,eye diseases ,Surgery ,030104 developmental biology ,chemistry ,Apoptosis ,Ageing ,Visual loss ,030221 ophthalmology & optometry ,Pigmented Epithelium ,medicine.symptom ,Riparian elderly ,business ,Food Science - Abstract
Ageing can cause disorders such as age-related macular degeneration (AMD), which leads to irreversible visual loss in elderly people. Given that nutrition may influence some age-related disorders, this study investigated, in vivo, the association between self-reported eyesight quality and daily guarana intake in riparian elderly subjects and, in vitro, the effects of guarana (Paullinia cupana) on retinal pigmented epithelium (RPE) cells exposed to paraquat. Just over half of the elderly subjects self-reported poor vision (n = 320, 50.8%), 234 (37.1%) self-reported regular eyesight, whereas just 76 (12.1%) self-reported good vision. Subjects that self-reported good vision presented a higher frequency of habitual guarana consumption. Guarana treatment was able to decrease apoptosis and necrosis events and differentially modulate gene expression and protein levels of caspases 1, 3 and 8 in RPE cells. This work provides new perspectives on the potential use of guarana against eye diseases due to its cytoprotective effects.
- Published
- 2017