1. Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor
- Author
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Hideo Harigae, Hiroshi Fujii, Hiroko Sato, Tomonori Ishii, Hiroka Komatsu, and Tsuyoshi Shirai
- Subjects
Aortic arch ,Pathology ,medicine.medical_specialty ,Filgrastim ,medicine.medical_treatment ,migratory aortitis ,Aorta, Thoracic ,Case Report ,030204 cardiovascular system & hematology ,chemotherapy ,Polyethylene Glycols ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal Medicine ,Medicine ,Humans ,Aortitis ,Aged ,granulocyte-colony-stimulating factor ,Chemotherapy ,business.industry ,Immunosuppression ,General Medicine ,medicine.disease ,Granulocyte colony-stimulating factor ,Pancreatic Neoplasms ,Descending aorta ,030211 gastroenterology & hepatology ,Female ,Neoplasm Recurrence, Local ,business ,Pegfilgrastim ,medicine.drug ,Granulocytes - Abstract
We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.
- Published
- 2020