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Start Over Author "Eve Devouge" Topic 0302 clinical medicine
2 results on '"Eve Devouge"'

1. Physical activity is associated with improved bone health in children with inflammatory bowel disease

Author

Elodie Drumez, Claire Spyckerelle, Florian Vidal, Djamal Djeddi, Céline Legrand, Eve Devouge, Dominique Turck, Serge Ganga Zandzou, Frédéric Gottrand, Stéphanie Coopman, Delphine Ley, Laurent Béghin, Laurent Michaud, Jérémy Vanhelst, Université de Lille, Inserm, CHU Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], CHU Amiens-Picardie, Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras, Hôpital Saint Vincent de Paul de Lille, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Centre Hospitalier de Roubaix, Centre hospitalier de Béthune, Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), and Université de Lille, LillOA

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Adolescent, [SDV]Life Sciences [q-bio], Osteoporosis, 030209 endocrinology & metabolism, Fitness Trackers, Critical Care and Intensive Care Medicine, Bone health, Inflammatory bowel disease, Pediatrics, 03 medical and health sciences, Absorptiometry, Photon, 0302 clinical medicine, Quality of life, Bone Density, Internal medicine, medicine, Bone mineral density, Humans, Healthy Lifestyle, Child, Exercise, 2. Zero hunger, Bone mineral, Inflammation, 030109 nutrition & dietetics, Nutrition and Dietetics, Lifestyle habits, business.industry, Confounding, Inflammatory Bowel Diseases, medicine.disease, Actigraphy, 3. Good health, [SDV] Life Sciences [q-bio], Osteopenia, Bone Diseases, Metabolic, Quality of Life, Female, business, Body mass index
Abstract

Bone health is an important concern in patients with inflammatory bowel disease (IBD). Low bone mineral density (BMD) is a powerful predictor of fracture risk in IBD patients. Physical activity (PA) plays an important role in bone health. However, PA data for children and adolescents with IBD are scarce. The primary aim is to evaluate the relationship between PA and BMD in children with IBD. The secondary aim was to assess the relationship between PA and quality of life. Eighty-four IBD paediatric patients (45 boys) aged 14.3 ± 2.7 years were included (disease activity: (i) remission, n = 62; (ii) mild, n = 18; (iii) severe disease, n = 1). BMD was measured using dual-energy X-ray absorptiometry and expressed as age- and sex-based Z-scores. Each patient wore a triaxial accelerometer for seven consecutive days for objective PA quantification. Quality of life was assessed using the PedsQL™ and energy intake was assessed prospectively for three days using a dietary diary. BMD Z-score was -0.96 ± 1.11. Only five patients (6%) fulfilled the recommendation of 60 min of daily moderate-to-vigorous PA (MVPA). The proportion of children with osteopenia and osteoporosis was 51% and 4%, respectively. After adjustment for confounders (pubertal status and body mass index), total PA and time in MVPA were positively associated with BMD (regression coefficient per one standard deviation increase in PA parameters = 0.26; P

Published
2020

2. Quantification of the methylation at the GNAS locus identifies subtypes of sporadic pseudohypoparathyroidism type Ib

Author

Agnès Linglart, Virginie Mariot, Anne Ronan, Caroline Silve, Catherine Naud-Saudreau, Dominique Simon, Stéphanie Maupetit-Méhouas, Hélène Bihan, François Feillet, Savitha Shenoy, Anne Lienhardt, Eve Devouge, Vincent Gajdos, Christelle Reynes, Jean-Claude Carel, Placide Agbo-Kpati, Guylène Bertrand, Immunologie et génétique du diabète de type 1, génétique multifactorielle en endocrinologie pédiatrique (U986), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biochimie hormonale, métabolique et génétique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'endocrinologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'endocrinologie, diabétologie, maladies métaboliques [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de pédiatrie [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Service de pédiatrie, Hôpital d'Arras, Leicester Royal Infirmary, University Hospitals Leicester, Hôpital de Lagny, Hunter Genetics Unit, Service de Pédiatrie, CH Bretagne Sud, Service de Pédiatrie médicale [CHU Limoges], CHU Limoges, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immunologie et génétique du diabète de type 1, génétique multifactorielle en endocrinologie pédiatrique ( U986 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Molécules Thérapeutique in silico, Recherche de molécules à visée thérapeutique par approches In Silico ( MTI ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ), Nutrition-Génétique et Exposition aux Risques Environnementaux ( NGERE ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lorraine ( UL ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Centre de référence des maladies rares du métabolisme du calcium et du phosphore, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], and Peer, Hal

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Adolescent, 030209 endocrinology & metabolism, Locus (genetics), Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Combined bisulfite restriction analysis, Molecular genetics, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Genetics, GNAS complex locus, medicine, Humans, natural sciences, Epigenetics, Child, Genetics (clinical), Pseudohypoparathyroidism, Genes, Dominant, 030304 developmental biology, 0303 health sciences, biology, Sequence Analysis, DNA, Methylation, DNA Methylation, medicine.disease, Phenotype, biology.protein, Female, STX16
Abstract

Background Pseudohypoparathyroidism type Ib (PHP-Ib) is due to epigenetic changes at the imprinted GNAS locus, including loss of methylation at the A/B differentially methylated region (DMR) and sometimes at the XL and AS DMRs and gain of methylation at the NESP DMR. Objective To investigate if quantitative measurement of the methylation at the GNAS DMRs identifies subtypes of PHP-Ib. Design and methods In 19 patients with PHP-Ib and 7 controls, methylation was characterised at the four GNAS DMRs through combined bisulfite restriction analysis and quantified through cytosine specific real-time PCR in blood lymphocyte DNA. Results A principal component analysis using the per cent of methylation at seven cytosines of the GNAS locus provided three clusters of subjects (controls n=7, autosomal dominant PHP-Ib with loss of methylation restricted to the A/B DMR n=3, and sporadic PHP-Ib with broad GNAS methylation changes n=16) that matched perfectly the combined bisulfite restriction analysis classification. Furthermore, three sub-clusters of patients with sporadic PHP-Ib, that displayed different patterns of methylation, were identified: incomplete changes at all DMRs compatible with somatic mosaicism (n=5), profound epigenetic changes at all DMRs (n=8), and unmodified methylation at XL in contrast with the other DMRs (n=3). Interestingly, parathyroid hormone concentration at the time of diagnosis correlated with the per cent of methylation at the A/B DMR. Conclusion Quantitative assessment of the methylation in blood lymphocyte DNA is of clinical relevance, allows the diagnosis of PHP-Ib, and identifies subtypes of PHP-Ib. These epigenetic findings suggest mosaicism at least in some patients.

Published
2010

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